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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201481 - 201490 of 207699 results
  1. SBIR Phase I:Restoring natural sleep for adolescents: circadian clock advancement at night assisted with mobile application-delivered cognitive behavioral therapy

    SBC: LUMOSTECH, INC.            Topic: DH

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to address chronic sleep deprivation among American teenagers, which has only been made worse by the recent pandemic. Adolescents' natural internal circadian clocks typically run 1-3 hours later than adults, leading to the tendency to stay up late, difficulty falling asleep, insufficient to ...

    SBIR Phase I 2022 National Science Foundation
  2. Commercialization of Selective Dyrk1a Inhibitors for Down Syndrome

    SBC: ILUMINOS THERAPEUTICS LLC            Topic: 106

    Project Summary Down syndrome (DS) is caused by human chromosome 21 trisomy (hsa21) and is the most common genetic form of intellectual and cognitive disability, occurring in ~1 in 700 live births. DS patients also exhibit age-related progressive cognitive decline, neurodegeneration, and the development of Alzheimerandapos;s disease (AD)-like pathology by 40-50 years of age. There are currently no ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. DIGITAL AND COST-EFFICIENT PRODUCTION OF HYBRID POLYMETHACRYLIMIDE FOAM CORES FOR RADICAL LIGHTWEIGHTING OF LIGHT-DUTY VEHICLES

    SBC: GENCORES INC            Topic: NA

    Lightweight, cost-efficient structural materials are vital to increasing Electric Vehicles' (E.V.s') efficiency, maximizing the effectiveness of infrastructure bill spending, and thus, building a sustainable all-electric future. The light-duty segment of the automotive industry will increase its share of lightweight materials from 30 to 95% by 2050. Structural sandwich structures, featuring a comp ...

    SBIR Phase II 2022 Department of Energy
  4. Modern Approach to Integrated Architecture Technology

    SBC: TAU TECHNOLOGIES LLC            Topic: SDA224001

    Tau Technologies will deliver to the Space Development Agency Integrated Architecture Technology Testbed (IATT), whose benefit will be the ability to confidently and accurately result in the generation of, for each National Defense Space Architecture (NDSA) element, cost, schedule and performance acquisition requirements.  This capability to enable SDA to confidently perform comparative analysis, ...

    SBIR Phase II 2022 Department of DefenseSpace Development Agency
  5. Integrated Architecture Technology

    SBC: QUATERNION CONSULTING, INC.            Topic: SDA224001

    Team QCI (QCI, subcontractors CKRS, G2SS) approach is centered on MS&A tools that QCI maintains and continually enhances.  This includes a robust, flexible simulation engine for a range of applications and that integrates with COTS, GOTS and opensource solutions.  The approach leverages successful work for Intelligence Community and DoD space craft architectural studies. The approach enables dev ...

    SBIR Phase II 2022 Department of DefenseSpace Development Agency
  6. A Web Service for Fragment-based Selectivity Analysis of Drug Leads

    SBC: CONIFER POINT PHARMACEUTICALS LLC            Topic: 400

    Significance: The goal of selective drug binding is a fundamental objective in the discovery and optimization of a compound on a trajectory toward helping patients and becoming an approved medication. To aid in this goal, our proposal aims to commercialize an innovative tool that addresses target selectivity in a rational de- sign methodology. The prototype tool leverages our large database of che ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Induction of bnAbs against HIV-1 gp41.

    SBC: NEOVAXSYN INC            Topic: 105

    PROJECT SUMMARY/ABSTRACTDespite the availability of effective anti-retroviral drugs, there are still about 38 million people living with HIV-1 infection and about 1.5 million people became newly infected just in 2020. A vaccine is critically needed to stop the AIDS pandemic. Induction of broadly neutralizing antibodies (bnAbs) against HIV-1 is the utmost critical goal towards the development of a ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Carbon Nanotube Enabled Delivery of mRNA for an HIV Vaccine Candidate

    SBC: LUNA LABS USA LLC            Topic: 105

    Project Summary Significant research has gone into the development of a safe and effective vaccine for HIV-1. Although many strategies have been attempted; none has been successfully established. Even a partially effective vaccine could decrease the number of people who are infected with HIV, further reducing the number of people who can pass the virus on to others. By substantially reducing the n ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Treating Drivers of Suicide in Primary Care using Jaspr Health

    SBC: EVIDENCE-BASED PRACTICE INSTITUTE, INC.            Topic: 350

    PROJECT SUMMARY/ABSTRACTSuicide remains a serious public health problem in the U.S. as rates have risen nearly each year since 2005, from 11.0 per 100,000 to 14.8 per 100,000 in 2018, totaling 48,344 in 2018; 1.4 million U.S. adults made a suicide attempt, and another 12 million thought seriously about killing themselves that same year. Alcohol use disorder (AUD) exponentially increases suicide ri ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Advanced generation infection-proof anti-HIV CAR-T with YY1 RNAi to block T cell exhaustion in NHP model

    SBC: IT Bio, LLC            Topic: NIAID

    This FastTrack Phase 1/2 application aims to create a new IND-ready CAR-T platform for the treatment of HIV, developed in the laboratory and tested in non-human primates. Molecular engineering techniques have been applied to create chimeric antigen receptors (CAR) expressed in T cells to target HIV-infected cells. CD4-based CARs are designed to achieve immune eradication of HIV1 infections through ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
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