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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201491 - 201500 of 207712 results
  1. Advanced generation infection-proof anti-HIV CAR-T with YY1 RNAi to block T cell exhaustion in NHP model

    SBC: IT Bio, LLC            Topic: NIAID

    This FastTrack Phase 1/2 application aims to create a new IND-ready CAR-T platform for the treatment of HIV, developed in the laboratory and tested in non-human primates. Molecular engineering techniques have been applied to create chimeric antigen receptors (CAR) expressed in T cells to target HIV-infected cells. CD4-based CARs are designed to achieve immune eradication of HIV1 infections through ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Carbon Nanotube-Mediated Gene Transfer into Human T-cells for CAR-T HIV Therapy

    SBC: Advanced Gene Transfer Company, Inc.            Topic: 105

    ABSTRACT The HIV pandemic has caused an estimated 33 million deaths to date. In the U.S. alone, 1.2 million people currently live with HIV and 34,800 new cases were diagnosed in 2019. This adds up to an estimated $16.4 billion for a lifetime of HIV treatment for patients in the U.S. HIV infects immune cells which express the CD4 and CXCR4/CCR5 co-receptors including helper T-cells. Even after a pa ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. STTR Phase I: Virtual Interfaces using Multi-Protocol, Augmented-Reality Activation-Based Control Transfer

    SBC: GYROPALM, LLC            Topic: HC

    The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project provides virtual interfaces that can be dynamically customized to address the challenge of user adoption in augmented reality (AR) products. This project overcomes previous limitations for AR such as the lack of interoperability, user-acceptance, scalability, and application-aware user intent ...

    STTR Phase I 2022 National Science Foundation
  4. Evaluation of a beta cell replacement therapy combined product that avoids the need for immunosuppression via localized induction of immune tolerance

    SBC: Regenerative Medical Solutions Inc            Topic: 200

    Project Summary/Abstract Diabetes is an increasingly important health problem worldwide. Despite recent advances in diabetes care, including long-acting insulin formulations, insulin pumps, and continuous glucose monitors, a majority of diabetic patients cannot achieve currently recommended targets for blood glucose control. Although transplantation of diabetic patients with donor-derived pancreat ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. SymHeal: A novel therapy for treating non-healing diabetic ulcers

    SBC: SELSYM BIOTECH INC            Topic: NIDDK

    PROJECT SUMMARY Non-healing wounds are a significant clinical problem both in the United States and globally. These wounds, defined as wounds that remain unhealed for upwards of 12 weeks, result in diminished quality of life for patients and greatly increase their susceptibility to serious infections such as gangrene that may lead to amputations. Non-healing wounds often arise as a side effect of ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Adjustable prosthetic sockets for children and adolescents with lower limb loss to accommodate growth

    SBC: IFIT PROSTHETICS, LLC            Topic: NICHD

    Pediatric limb loss, although relatively infrequent compared to adults, results in substantial hardship for children and their families. The principal business interest? iFIT Prosthetics, LLC®? successfully developed and manufactured innovative, fully adjustable, transtibial and transfemoral prosthetic devices, and demonstrated their safety, comfort, and functionality in adults. Made of injection ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. SYNTHETIC BIOLOGY APPROACH TO CRITICAL METAL EXTRACTION FROM WASTE ELECTRONIC COMPONENTS TO ENSURE A ROBUST SUPPLY OF CRITICAL MATERIALS FOR CLEAN ENERGY

    SBC: Infinite Elements, Inc.            Topic: NA

    Most end-of-life electronics (e-waste) end up in landfills where it causes serious environmental problems. While the glass and metals in e-waste components can be recycled, conventional extraction methods rely on energy-intensive processes that are inefficient and expensive when applied to e-waste that contains mixed materials and small amounts of metals. To make e-waste recycling economically via ...

    SBIR Phase I 2022 Department of Energy
  8. SYNTHETIC BIOLOGY APPROACH TO CRITICAL METAL EXTRACTION FROM WASTE ELECTRONIC COMPONENTS TO ENSURE A ROBUST SUPPLY OF CRITICAL MATERIALS FOR CLEAN ENERGY

    SBC: Infinite Elements, Inc.            Topic: NA

    Most end-of-life electronics (e-waste) end up in landfills where it causes serious environmental problems. While the glass and metals in e-waste components can be recycled, conventional extraction methods rely on energy-intensive processes that are inefficient and expensive when applied to e-waste that contains mixed materials and small amounts of metals. To make e-waste recycling economically via ...

    SBIR Phase II 2022 Department of Energy
  9. KMI-Aware Mesh Network NSA-Certifiable Cryptographic Solution

    SBC: Arkham Technology Limited            Topic: HQ085021S000106

    Hypersonic weapons are a clear and present danger to our country. To defend against these high-speed weapons, the sensor-to-shooter chain must move sensor data securely without time delays. For incoming hypersonic and ballistic threats, the Space Development Agency (SDA) must transfer large quantities of targeting data in real-time across a mesh network of satellite crosslinks, and back-and-forth ...

    STTR Phase II 2022 Department of DefenseSpace Development Agency
  10. Integrated Model Based Enterprise Architecture (MBEA) and Model-based Systems Engineering (MBSE) Marketplace for the U.S. Government and its Support Contractors

    SBC: Novarity Tech Services            Topic: SDA224001

    Design and prototype of an integrated Model Based Enterprise Architecture (MBEA) and Model-based Systems Engineering (MBSE) digital Marketplace for the U.S. Government and its Support Contractors to develop and validate traceable requirements in support of the Space Development Agency’s National Defense Space Architecture (NSDA).

    SBIR Phase I 2022 Department of DefenseSpace Development Agency
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