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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201501 - 201510 of 205043 results
  1. Computational tools to analyze SNP data from patients with mental illness

    SBC: Spectroglyph, LLC            Topic: NIGMS

    DESCRIPTION: While the detection and characterization of intact proteins and protein complexes is an exciting prospect, current proteomics measurement capabilities are lacking in a variety of crucial aspects such as measurement throughput, detection of low abundance proteins, and substantial issues associated with data quality including the confidence of protein identifications, under-sampling an ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  2. Live-Cell Assays of ER and Golgi Enzyme Activities

    SBC: LUCERNA INC            Topic: NIGMS

    DESCRIPTION: Sirtuins and ADP ribosyltransferases (ARDTs) are two families of related enzymes that have important medically relevant functions. For example, SIRT3, a mitochondrial sirtuin, controls mitochondrial function, and thereby exerts a strong effect on metabolism, obesity, type 2 diabetes, and metabolic syndrome. There is a major need to have simple assays to measure the activity of SIRT3, ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  3. Reagents for Targeted Ablation of Residual Contaminating Pluripotent Stem Cells

    SBC: Mandala Biosciences LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Human pluripotent stem (hPS) cells have great potential as a renewable source of cells for drug discovery, disease modeling and for transplantation to replace cells lost to degenerative diseases or injury. A critical barrier to the successful application of hPS cell research is the lack of methods for producing pure populations of hPS cell derivatives. Contami ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Characterization of a low mutation rate E. coli in extended fermentation

    SBC: SCARAB GENOMICS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): This application aims to test a new Scarab E. coli strain, MDS42pdu, for commercial fermentation to produce biopharmaceuticals, amino acids and biofuels. It is designed for a very low rate of point mutations and Insertion Sequence transposition, especially in the stress conditions of recombinant protein production. We propose here to study the impact on a funda ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  5. Transcriptome profiling by high throughput RNA Sequencing

    SBC: BIOO SCIENTIFIC CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): Recent advances in massively parallel cDNA sequencing (RNA-seq) have paved the way for comprehensive analysis of the transcriptome, a set of all RNA molecules including mRNA, rRNA, tRNA and other non-coding RNAs in oneor more populations of cells. RNA-Seq can identify the precise location of transcription boundaries, show how exons are connected and reveal sequ ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  6. Molecular Light Switch for Controlled Gene Expression

    SBC: LUCIGEN CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): Experimental manipulation of gene expression is a widely used technique that is crucial to much of modern biomedical research. The ability to control the timing and expression level of recombinant genes is central to the production of recombinant protein for basic research as well as for the synthesis of biological pharmaceuticals. Commercially available system ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  7. Quantitative dual-mode scanner for breast cancer therapy

    SBC: GENE THERAPY SYSTEMS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Efficient delivery of DNA into E. coli remains a major limitation in the construction of high complex and representative gene libraries. The most efficient way developed to date is using electroporation - delivering anelectric discharge to cell creating channels through which DNA can enter. We have created a mutant E. coli strain through a novel evolution proce ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  8. A THz Resonator for Solid-State DNP-NMR Spectroscopy

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The proposed research focuses on the development of a terahertz (THz) resonator for Dynamic Nuclear Polarization (DNP) enhanced solid-state NMR spectroscopy (ssNMR). With DNP, the inherently small signal intensities inan NMR experiment can be enhanced by several orders of magnitude. This significantly increased overall sensitivity will be of great value for man ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  9. Technology for bioactivity based discovery of novel cytokine receptor agonists

    SBC: MEDIKINE INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Medikine will use SBIR funding to develop a new technology that will greatly accelerate the discovery of peptide agonists of cytokine receptors, and will make possible the re-engineering of these newly discovered agonists to exhibit novel and medically-valuable bioactivity profiles. This technology will enable the sorting of enormous libraries of stochastically ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  10. Structurally Diverse Encoded Peptide Sets

    SBC: CELL MICROSYSTEMS INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Cell Microsystems is a North Carolina-based start-up biotechnology company whose mission is to commercialize a novel, yet affordable, platform for the efficient isolation of viable, single cells or colonies from a mixedpopulation while the cell/colony remains adherent or encapsulated to a solid surface. The company's IsoRaft technology is based on a uniq ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
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