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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201811 - 201820 of 207728 results
  1. Efficient scouting instrumentation for the determination of reverse micelle encap

    SBC: DAEDALUS INNOVATIONS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Detailed knowledge of the structures is a vital component of our understanding of the molecular basis of life. From a practical point of view, the atomic-scale structure of the protein can potentially greatly facilitatethe design of effective pharmaceuticals. Modern nuclear magnetic resonance (NMR) spectroscopy continues to be a central technique in the charact ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  2. Statistical Methods for Incomplete Data with Measurement Errors

    SBC: Data Numerica Institute, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Missing data and measurement errors are common problems in statistical data analysis. We are interested in experimental and observational studies where there exist missing data and measurement errors problems. Examplesinclude health surveys containing non-responders or missing items, surrogate marker data with measurement errors, etc. The applications could be ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  3. Automated Large and Mid Scale Nucleic Acid Preparation

    SBC: MacConnell Research Corporation            Topic: NIGMS

    DESCRIPTION (provided by applicant): This research involves the development a disposable purification cassette and bench-top electrophoretic processing instrument that will purify one milligram or more of plasmid DNA from recombinant culture in 60 minutes.The purification method to be employed in this work is a derivative of proven electrophoretic separation technology that our company developed f ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel High-Efficiency Transfection Technology

    SBC: Lavax, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Transfection is the process of introducing nucleic acids into eukaryotic cells. Not only is it a key step in medical treatment involving gene therapy and RNA interference, but it is also a powerful tool for studying gene function and protein expression in a cell. Many commercial products for transfection have been available on the market, but none has achieved ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  5. Robotic System with Multiplexed DOF Control for Minimally Invasive Interventions

    SBC: ACOUSTIC MEDSYSTEMS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Acoustic MedSystems proposes to develop an image-guided robot for MRI, CT and fluoroscopy guidance. The robot will be used for brain, prostate, liver, kidney, breast, and spine intervention. A general purpose robotic manipulator will be designed with development and implementation of a specific configuration for interventional medical biopsy and treatment use. ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  6. Highly Fluorescent Magnetic Nanoclusters for Effective and Multiplexed Separation

    SBC: NVIGEN            Topic: NIGMS

    DESCRIPTION (provided by applicant): The ability to effectively isolate rare cells and identify subset of cell characteristics could provide significant prognostic and therapeutic implications ranging from cancer diagnostics to stem cell therapies. The rare nature of these cells imposes particular challenge on the functionality and robustness of the separation and analysis methodology. Nanotechno ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  7. In-process glycoprofiling during recombinant therapeutic glycoprotein production

    SBC: GLYCOSENSORS AND DIAGNOSTICS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): The biologics market is the most rapidly growing sector of the pharmaceutical industry, and the US Food and Drug Administration (FDA), as well as the European Medicines Agency (EMEA), requires that the glycoprofiles ofall such therapeutic glycoproteins and antibodies be extensively characterized and fall within the specifications defined at the time of licensu ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  8. Byologic: Software for Mass Spectrometric Protein Drug Assays

    SBC: PROTEIN METRICS INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Due to the complexity of proteins and their biological production, characterization of protein pharmaceuticals ( biologics ) poses much more demanding analytical challenges than do small-molecule drugs. Consequently,many disparate biochemical analytical techniques are needed to characterize biologics. Because of the rapidly increasing power of mass spectrome ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  9. Production of Activated TDP-Deoxysugars in E. coli

    SBC: ZUCHEM INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The ultimate goal of the proposal presented herein is to use E. coli as whole cell biocatalysts for the production of a wide variety of TDP-deoxysugars including di- and tri-deoxysugars, amino sugars and branched-chainsugars. These specialized activated hexoses are found as important structural components throughout plant and microbial secondary metabolites oft ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  10. Identification of Biomarkers of Cardiotoxicity using Metabolomics of Human Plurip

    SBC: STEMINA BIOMARKER DISCOVERY, INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Cardiotoxicity, as a result of adverse drug effects, is a serious problem that has yet to be effectively screened prior to patient exposure. Cardiac safety is one of the leading causes of compound attrition in the pharmaceutical industry and withdrawal of FDA-approved drugs from the market. The purpose of this proposal is to alleviate the financial burden of co ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
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