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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201821 - 201830 of 207728 results
  1. Mesodissection Device

    SBC: AVANSCI BIO, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Mesodissection Device Microscopic analysis of tissue mounted on glass slides is commonly used to study cancer, nonneoplastic entities such as heart disease and diabetes, and normal cell function. At a growing rate, researchers are utilizing various micro and macro tissue dissection techniques to recover specific areas of interest from a slide mounted tissue sec ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a CMOS-based Very Large-Format X-ray Detector for Synchrotron Beam

    SBC: Research Detectors Incorporated            Topic: NIGMS

    DESCRIPTION (provided by applicant): We propose to develop a large, high performance X-ray detector system for protein crystallography at synchrotron beamlines, using Active Pixel Matrix Sensor CMOS (complementary metal-oxide-semiconductor) technology. Itwill be a 47.05cm x 44.32cm (4700 x 4428 pixel) system of 1005m pixels. Each pixel will be inactive for just 225s during frame readout; the entir ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  3. Discovery of A-beta Oligomer Antagonists via 3D Pharmacophore Space Analysis

    SBC: Acelot, Inc.            Topic: NIGMS

    The goal of this proposal is to discover drug-like retinoid X receptor (RXR) agonists that can halt and reverse the progression of Alzheimer's disease (AD). The research strategy is to target ApoE gene expression through RXR agonists; this has recently been shown to improve A turnover, reduction in A plaque area, and the reversal of cognitive, social and olfactory deficits. The research pla ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  4. New Building Blocks for the Synthesis of Modified RNAs

    SBC: AM BIOTECHNOLOGIES, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Functional RNA molecules such as aptamers, siRNAs, miRNAs, and related compounds have enormous potential as human therapeutics and as tools for elucidating gene regulation in vivo. To reach this potential, such molecules must be highly potent and highly nuclease resistant. Unmodified RNAs typically do not meet these requirements. A variety of chemical modifica ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Anti-OLAM Aptamers as Novel Analgesics

    SBC: Operational Techologies Corporation            Topic: NIGMS

    DESCRIPTION (provided by applicant): Development of Anti-OLAM Aptamers as Novel Analgesics The management of pain remains a major health care problem due to an incomplete understanding of pain mechanisms. TRPV1, a prominent member of the transient receptorpotential (TRP) family of ligand-gated ion channel, detects noxious chemical and physical stimuli in peripheral tissues. Both pharmacological an ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  6. Phage Display Isolation of Antibodies against Antigenically Conserved Membrane Pr

    SBC: INTEGRAL MOLECULAR INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): We propose to use a novel technology, the Lipoparticle, to capture and concentrate structurally intact membrane proteins in a format amenable to phage panning for MAb isolation. The use of Lipoparticles to pan phage display libraries represents a valuable approach for obtaining antibodies against conserved membrane protein antigens because 1) Lipoparticles con ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  7. Analytical Metagenomics Paradigm for Structure Based Screening

    SBC: LUCIGEN CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): Each year, 100,000 Americans perish due to untreatable bacterial infections. The societal benefits of new antibiotic compounds that are effective against numerous multiple drug resistant pathogens would be significant.The best possible source for new antibiotic scaffolds with potentially novel mechanisms of action is within natural environments, particularly so ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  8. Accelerating Wound Healing Using RNAi

    SBC: Somagenics, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The growing populations of the elderly and those with type-II diabetes are at high risk for developing chronic wounds that are slow to heal. Effective therapeutics to promote wound healing can significantly improve thelives of those faced with chronic wounds as well as injured military personnel and others with acute wounds. Somagenics has developed an RNAi-bas ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  9. Parsimonious Models for Survival Data

    SBC: INSILICOS            Topic: NIGMS

    DESCRIPTION (provided by applicant): This Small Business Innovation Research project addresses the problem of biomarker detection in clinical and high-throughput data. The objective is to investigate new approaches for deter- mining, from data consisting of many possibly irrelevant or redundant measurements, a highly predictive and interpretable model that involves only a small number of measureme ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  10. Use of Spray-Drying as a Manufacturing Process for Oral Adenovirus Vaccine

    SBC: PAXVAX, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The 2009 H1N1 pandemic illustrates a critical weakness in our ability to respond to a pandemic threat. The ability to ramp up production of vaccine doses within the critical period from the discovery of the threat is hindered by two major supply constrictions: 1) production technology for producing influenza vaccines in eggs; and 2) the logistical consideration ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
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