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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201861 - 201870 of 207728 results
  1. Peptide-coated skin substitutes for the treatment of burn injuries and wounds

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Burn injuries and chronic wounds present a significant burden to patients and the US healthcare system. Each year in the US, there are 450,000 burns that require medical treatment and 45,000 burns that require hospitalization. One of the most common causes of chronic wounds, venous ulcers, occurs in 600,000 to 1,500,000 US patients; 15% to 20% of patients with ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  2. DEVELOPMENT OF RATIOMETRIC IMAGING PROBE SYSTEM FOR MONITORING INFLAMMATION

    SBC: PROGENITEC INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Inflammation is a major unifying syndrome associated with a variety of injury and diseases. When severe, inflammatory diseases can endanger and even kill patients. Direct diagnosis of the extent of inflammatory responses is often made histological with an invasive biopsy. Furthermore, multiple biopsies are often required to assess the extent of inflammatory rea ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  3. Automated Macrodissection Device

    SBC: AVANSCI BIO, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Microscopic examination of formalin fixed, paraffin embedded (FFPE) tissue sections mounted on glass slides is the cornerstone of clinical histopathology. Ancillary molecular testing is often required for diagnosis, risk stratification, ad treatment planning, particularly in cancer. Molecular testing often involves mutation or expression analysis of nucleic aci ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  4. Methyltransferease sensors for homogenous HTS assays

    SBC: LUCERNA INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Methyltransferases (MTs) are a diverse class of enzymes that catalyze the transfer of a methyl group from S-adenosylmethionine (SAM) to a substrate molecule. MTs catalyze reversible covalent modifications of proteins aswell as a variety of biological molecules, including proteins, such as histones, as well as DNA, RNA, hormones, lipids and metabolites. Over 200 ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  5. Hyperquenching Cryocooler for Biomolecular X-ray Crystallography

    SBC: MITEGEN, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): The overall goal for this project is to design a compact cryocooling device for fast, reproducible and reliable cryopreservation of protein and virus crystals for X-ray cryocrystallography. X-ray crystallography is themost powerful and widely used tool for determining the molecular structure of proteins, viruses, nucleic acids and biomolecular complexes. Flash- ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  6. High Sensitivity Solution DNP-NMR Probe with a Photonic Band Gap Resonator

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The proposed research focuses on the development of a NMR probe for Dynamic Nuclear Polarization (DNP) enhanced solution-state NMR spectroscopy. With DNP, the inherently small signal intensities in an NMR experiment can be enhanced by several orders of magnitude. This significantly increased overall sensitivity will be of great value for analytical application ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Method to Improve Function of SC-Derived Hepatocytes

    SBC: PRIMORIGEN BIOSCIENCES INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Primorigen Biosciences SBIR Proposal Abstract Primorigen Biosciences will use SBIR funds to develop an advanced cell culturing methodology to increase the efficiency of directed differentiation and to boost functional maturity of induced pluripotent stem cell-derived hepatocytes. The new technology uses proprietary cell culture media additives to recreate nativ ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  8. Submerged Printing of Lipid and Membrane Protein Arrays

    SBC: Carterra, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The goal of this Phase I SBIR project is to develop a device for automated array printing of lipids and membrane proteins onto submerged microtiter plate surfaces in a way that maintains their activity and function. Ourproprietary 3D microfluidic printing technology is uniquely capable of sealing and printing arrays of biomolecules onto submerged surfaces in a ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  9. Improving in vivo stability of sphingosine kinase inhibitors

    SBC: SPHYNKX THERAPEUTICS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): We and others have hypothesized that inhibiting SphK1 is a powerful therapeutic strategy in pathologies that are characterized by cell hyperproliferation, e.g. cancer and fibrosis. This hypothesis was generated largelythrough the use interfering RNA strategies - there is a paucity of potent, selective small molecule inhibitors of SphKs. Sphingosine kinase type ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  10. The 3D Immersive Display: Validation of a Virtual Reality Technique for Pain Cont

    SBC: FIRSTHAND TECHNOLOGY, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The use of virtual reality for pain control; henceforth, referred to as VR analgesia, has been shown to be effective in clinical treatment of acute pain in wound care, cancer care, physical therapy and routine hospitalprocedures. VR is believed to be effective based on gate theory of cognitive load, supported by findings that correlate levels of immersion and ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
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