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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201861 - 201870 of 207712 results
  1. Therapeutic Potential and Targeted Homing of ECSOD-MSCs in Animal Model of Mucositi

    SBC: TARGAZYME, INC.            Topic: NIDCR

    DESCRIPTION (provided by applicant): In the present submission we are requesting funding to support studies designed to assess proof-of-concept for a novel cell-based approach that possesses the potential to concurrently address multiple pathobiologic mechanisms initiated by chemo- + high dose irradiation. The importance of this effort is underscored by fact that oral mucositis is a common side ef ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Smad7 use in oral mucositis treatment

    SBC: Taiga Biotechnologies, Inc.            Topic: NIDCR

    DESCRIPTION (provided by applicant): Summary Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. About 17.9 millionadults have been diagnosed with cancer in the United States, which is ~7.9% of the total population. At least 40%, and up to 70%, of individuals ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Novel Methacrylate-Thiol-Ene Composites for Dental Restorative Materials

    SBC: COLORADO PHOTOPOLYMER SOLUTIONS, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Novel Methacrylate-Thiol-Ene Composites for Dental Restorative Materials. As the demand for aesthetically pleasing restorative materials has increased, so has the desire and demand for improved performance. Despite their increasing prevalence, the resin phase of these materials has remained largely unaltered since Bowen first proposed the materials nearly 50 ye ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Cellularized bone grafts for point-of-care complex craniofacial reconstructions

    SBC: EPIBONE, INC.            Topic: NIDCR

    DESCRIPTION (provided by applicant): EpiBone is a company engineering living, anatomically precise and functionally mature bone grafts from autologous stem cells derived from fat aspirates. In the United States alone, there are over 400,000 emergency visits per year due to facial trauma, with ~20% of facial fractures being complex and involving more than one bone. Our goal with this SBIR is to dev ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. High resolution 3D dental X-ray imaging system with low dose and low cost

    SBC: XINTEK, INC.            Topic: NIDCR

    ? DESCRIPTION (provided by applicant): The need to reliably detect proximal and occlusal caries remains a high oral health priority. Caries affect millions of Americans and, when undetected, could evolve into more serious conditions that may require largerestorations, endodontic treatment, or extraction. The caries detection sensitivity using existing dental image modalities, 2D intra-oral imagin ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Engineered Neurotensin Fragments Targeting Neuropathic Pain

    SBC: JT Pharmaceuticals, Inc.            Topic: NIDCR

    DESCRIPTION (provided by applicant): Neuropathic pain management is a major unmet clinical need. Classically used medications, including opioids and non-opioids (primarily NSAIDs), have major side effects associated with their use, and many individuals donot respond to any medications. Neuropathic pain drugs with novel mechanisms of action are being sought as an alternative; however, the only succ ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Salivary oxytocin as a biomarker for autism spectrum disorder

    SBC: SALIMETRICS, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Oxytocin is a secreted, peptide hormone that is involved in modulating a wide range of central and peripheral physiological responses. Most notably, it has been implicated in social behaviors, including parental behavior, the formation of social bonds, and the management of stressful experiences. Given the increased interest and important role of this peptide i ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a Pan-HIV Proteomic Chip

    SBC: ImmPORT Therapeutics Inc dba Antigen Discovery Inc            Topic: NIDCR

    DESCRIPTION (provided by applicant): HIV-1 causes the largest number of deaths from a single infectious agent in the world today. Despite considerable advances in treatment of HIV-1 infection and AIDS, which it causes, there is an urgent need for better methods of prevention and treatment of HIV-1 infection. The development of a safe and effective vaccine to prevent HIV-1 infection or the subseque ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a Porcine Model of Autosomal Dominant Polycystic Kidney Disease

    SBC: EXEMPLAR GENETICS, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common, potentially fatal genetic disorders in humans with an incidence of 1 in every 500-1000 individuals. The majority of ADPKD cases (85%) are caused by mutations in the PKD1 gene, which encodes polycystin-1. ADPKD is a systemic disorder that often leads to kidney failure and extrarenal ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Parents.Cope: A tool for Parents of Adolescents with T1DM

    SBC: New England Research Institutes, Inc.            Topic: NIDDK

    PROJECT SUMMARY/ABSTRACT Type 1 diabetes (T1DM) is the most common chronic illness in children, affecting 1 in 400 with evidence that its prevalence is increasing worldwide. Parents of children with T1DM are responsible for a labor-intensive and complicated daily regimen that has been described as an overwhelming experience, requiring constant vigilance. The prevalence of anxiety symptoms for par ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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