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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201901 - 201910 of 207725 results
  1. Nano-Antibodies for Studying RNA Modifications

    SBC: ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS            Topic: NIDA

    DESCRIPTION (provided by applicant): The goal of the proposed Phase I research is to develop a set of commercial reagents for recognizing 2'-O-methyladenosine (Am), 2'-O-methylcytidine (Cm), 2'-O-methylguanosine (Gm) or 2'-O-methyluridine (Um), as well asindiscriminately to all four 2'-O-methyl ribose moiety. The core technologies that serve as the foundation of these new ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Novel platform for isolation of rabbit monoclonal antibodies against modified RNA bases

    SBC: AVANTGEN INC            Topic: NIDA

    DESCRIPTION (provided by applicant): RNA editing and post-transcriptional modification is emerging as a key epigenetic mechanism for fine tuning genetic diversity and RNA function of particular importance in the brain. However, while some RNA editing processes have been relatively well described, other RNA modifications are poorly understood and many questions remain about the true significance of ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Nanobodies for detecting and manipulating A to I editing enzymes and their modified RNA products

    SBC: ABZYME THERAPEUTICS LLC            Topic: NIDA

    DESCRIPTION (provided by applicant): Adenosine to inosine or A-to-I RNA editing executed by ADAR family proteins is abundant in the central nervous system (CNS). The availability of tools to monitor and manipulate both ADAR enzymes and A-to-I RNA modifications will facilitate investigation of the relationships between specific A-to-I conversions and their function in CNS development. The goal of t ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Synthetic antibodies for monitoring modified RNAs

    SBC: ROCKLAND IMMUNOCHEMICALS, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): Post-transcriptional RNA modification plays an important role in biological processes. For example, adenosines to nosiness or A-to-I editing are most abundant in the central nervous system (CNS) and essential for normalCNS development. Presently, the available reagents for detection, quantitation, or immunoprecipitation of modified RNA are extremely limited. Ro ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Affinity reagents for the detection of modified RNAs and Transcriptome-wide mapping of RNA modifications

    SBC: GUILD ASSOCIATES INC            Topic: NIDA

    DESCRIPTION (provided by applicant): Biological RNAs undergo extensive post-transcriptional modifications. These modifications are important in promoting the accuracy and efficiency of gene expression in biological systems. To decipher the functions of RNA modifications, robust analytical tools and methods that enable scientists to monitor, manipulate, and transcriptome-wide mapping RNA modificat ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Developing a standardized kit and normal reference profile for circular RNAs in the nervous system

    SBC: COFACTOR GENOMICS, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): Modified ribonucleic acids (RNA) are important regulators of translation and other cellular pathways. Non- coding RNAs like microRNAs play significant roles in neuronal development, and can serve as biomarkers for psychiatric disorders. Another such modified RNA is circular RNA (circRNA), a non-coding transcript present in the cytoplasm. Since circRNAs are pres ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Microfabricated Cochlear Electrode Arrays

    SBC: MEMStim LLC            Topic: NIDCD

    DESCRIPTION (provided by applicant): In the USA, about 36 million adults suffer from hearing loss and three out of every 1,000 children are born deaf or hard-of-hearing. When conventional hearing aids provide no appreciable benefit, implantable electronicdevices using electrode arrays inside the cochlea are a viable solution. With these cochlear implants, the profoundly deaf achieve reasonable wor ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. A new two-drug combination therapy for noise-induced hearing loss

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    DESCRIPTION (provided by applicant): Noise is the most common occupational and environmental hazard, thus it is not surprising that noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit, second only to age-related hearing loss (presbycusis). Although therapeutics that target the free radical pathway have shown promise for reducing NIHL, there are no FDA- ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a software package for speech therapy.

    SBC: VULINTUS, INC            Topic: NIDCD

    DESCRIPTION (provided by applicant): We propose the development of Optic-speech, a system designed to use real-time animation of 3D models to visualize tongue movement during speech for use in guiding speech therapy for dysarthria. Approximately 3 millionAmericans suffer from dysarthria yearly, and the inability to speak can quickly lead to a reduced quality of life. Existing therapies can be inte ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Individualized Signal Processing Strategy to Reduce Hearing Health Care Cost/Disp

    SBC: SECURBORATION, INC.            Topic: NIDCD

    This project describes a novel approach to automate and individualize the signal processing strategy for hearing aids that can result in improved speech intelligibility in background noise, greater user satisfaction and acceptance for hearing aids, and reduce barriers to affordable hearing health care. The proposed Individualized Signal Processing Strategy (ISPS) is based upon individual performan ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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