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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 201931 - 201940 of 207712 results
  1. High Throughput Chromatin Immunoprecipitation on Formalin Fixed Paraffin Embedded

    SBC: ACTIVE MOTIF, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Epigenetic mechanisms regulate gene expression potential and alterations in epigenetic marks, such as DNA methylation and histone modifications, have been associated with a variety of diseases. Tissue samples (both research and clinical) are often preserved by formalin fixation and paraffin embedment (FFPE), which allows for long term storage in minimally contr ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Nanobind FFPE DNA/RNA Extraction

    SBC: Circulomics Inc.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Nanobind FFPE DNA/RNA Extraction Despite the growing need for and the demonstrated potential advantages of molecular biomarkers, it has proven difficult to routinely employ them in the diagnosis and management of patients. One reason for this failure has been the logistical challenges of obtaining, rapidly processing, storin, and transporting quick-frozen tissu ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a non-destructive molecular extraction platform for quantitative p

    SBC: BIO-QUICK CORPORATION            Topic: NIEHS

    DESCRIPTION (provided by applicant): In this study, we propose a Non-Destructive Molecular Extraction (NDME) platform to perform quantitative proteomics analysis of FFPE specimens with SILAC cell dot controls. The NDME technique can directly extract proteins from a single fixed tissue section without destroying tissue morphology. The tissue section remaining after NDME will be used for histopathol ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Comprehensive Solution for Transcriptome Profiling of Archived Tissues

    SBC: ASURAGEN, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): The overall goal of this proposal is to expand the capability for molecular analyses of formalin fixed paraffin-embedded (FFPE) specimens through the use of whole transcriptome profiling with next generation sequencingtechnology (RNA-Seq). An end-to-end strategy will be developed that includes both experimental and analytical methods to address challenges speci ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Lead Detection in Soil and Sediment

    SBC: MORPHIX TECHNOLOGIES, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): EPA's Cleaning-Up the Nations Waste Sites: Market and Technology Trends (2004) estimates that there are 294,000 contaminated waste sites in the United States. Characterizing suspected contaminated sites remains difficult, time consuming, and expensive. Samples are typically sent to laboratories for costly testing that can take weeks. While some field det ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. On Site Mercury Remediation via Activated Fly Ash

    SBC: POLLUTION CONTROL TECHNOLOGIES, LLC            Topic: NIEHS

    DESCRIPTION (provided by applicant): Coal-fired power plants and burners are vital drivers of the U.S. economy-but they unfortunately produce substantial amounts of mercury (Hg) that are seriously harmful to human health, particularly linked to damages ofthe nervous system. Healthcare costs due to Hg exposure are estimated to be in the billions of dollars annually. New mercury-emission regulations ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Enhanced Non fouling Membranes for Water Purification and Recycling

    SBC: LYNNTECH INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Many industrial processes produce difficult to treat wastewater that must be purified before being discharged. In many cases, the wastewater cannot be treated cost effectively and often massive quantities of water are therefore land-applied for disposal, disposed of underground, or discharged into our surface water supply leading to a significant impact on the ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Rapid Field Testing Kit for Determining Arsenic Contamination in Groundwater

    SBC: CAMBRIAN INNOVATION, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): While arsenic has had broad industrial, agricultural, and medical applications, it is considered a highly toxic substance and its disposal is highly regulated. Arsenic is one of the most pervasive contaminants of drinking water in developing countries, as well as in the regions of the mid- and southwest United States, particularly near contaminated Superfund si ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Perchlorate Sensing Platform for In-Field Groundwater Monitoring

    SBC: TDA RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): New and improved technologies are needed for monitoring perchlorate contamination in groundwater. TDA Research Inc. proposes a new portable sensor platform for in-the-field monitoring of the perchlorate anion, ClO4-, for which the recommended remediation goal is less than 3.6 parts-per-billion (3.6 ppb) in water. Perchlorate is a toxic anion that interferes wi ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Novel 3D high-content/throughput assay with mobile device-based data acquisition

    SBC: CHEMOSEN3D INC            Topic: NIEHS

    DESCRIPTION (provided by applicant): Currently available models for toxicity screening are not always accurate predictors of toxicity in humans. Animal models are commonly used, but they are costly, time-consuming, and ethically challenging, they vary between species, and they do not accurately predict toxicity in humans. In vitro toxicity tests have been explored for years as cheaper alternatives ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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