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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 202161 - 202170 of 207725 results
  1. Rho GTPase inhibitors for refrigerated platelet storage

    SBC: P2D, INC            Topic: NHLBI

    ABSTRACT The use of platelet transfusions has increased dramatically since 1980s, but a safe, long-term platelet storage method remains missing. Current practice has platelets stored at 20 to 24 C after preparation, which has a limited lifetime up to 5 days primarily due to concerns about bacterial contamination. Refrigerated storage reduces platelet life-span because it causes glycoprotein-Ib (GP ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Depletion of iNKT Cells in the Treatment of Hypoxic Crises in Sickle Cell Mice

    SBC: NKT THERAPEUTICS, INC.            Topic: NHLBI

    There is a central role for iNKT cells in mediating inflammatory responses in sickle cell disease. NKT Therapeutics has developed a humanized monoclonal antibody (NKTT120) that can specifically mediate iNKT cell depletion by antibody and complement directed cellular cytotoxicity. We are currently engaged in a safety/PK Phase 1 study in stable sickle cell disease patients. Although the use of speci ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Mobile multifunctional tool for monitoring and management of respiratory diseases

    SBC: TF HEALTH CORPORATION            Topic: NHLBI

    DESCRIPTION (provided by applicant): Mobile multifunctional tool for monitoring and management of respiratory diseases Chronic Obstructive Pulmonary Disease (COPD) and asthma affect millions of people worldwide. Because there is no permanent cure for thesediseases, efficient management of the patients over their entire lifetime are needed, which becomes increasingly difficult with the rapid rise i ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Thromboresistant Small Diameter Tissue-Engineered Vascular Grafts

    SBC: HUMACYTE, INC.            Topic: NHLBI

    The overall goal of this Phase I SBIR application is to develop a non-cell-based means of inhibiting coagulation and platelet activation on engineered vascular grafts, so that small-diameter arterial grafts may be available off the shelf. This arterial graft will consist of human engineered tissue that is decellularized and coated with a novel, covalently-bound layer that mimics aspects of the e ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Mitigation of Reperfusion Injury During CPR to Improve Cerebral Recovery

    SBC: RESQSYSTEMS, INC.            Topic: NHLBI

    Abstract On average, gt90% of patients who suffer from a cardiac arrest die. Nearly all die unexpectedly from this leading cause of death, in part, because the essential components of standard CPR (S-CPR): manual chest compressions at a rate of 100/min, 1to 1.5 inches in depth and positive pressure ventilations, are an inherently inefficient process, providing less than 25% of normal blood flow to ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. FLEXIBLE SKIN-ADHESIVE PATCH FOR DIAGNOSING SLEEP DISORDERED BREATHING

    SBC: SOMNARUS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The objective of this study is to test the feasibility of an innovative flexible skin-adhesive device that diagnoses obstructive sleep apnea and other sleep disordered breathing. Sleep apnea is a common disease that leads to hypertension, diabetes and cardiovascular disease. Sleep disordered breathing is commonly diagnosed with polysomnography and portable slee ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Improved Accuracy with Reduced Radiation Dose for SPECT MPI

    SBC: ADAPTIVEPHARMA, LLC            Topic: NHLBI

    PROJECT SUMMARY/ABSTRACT Coronary Artery Disease (CAD) is responsible for an unacceptable death rate, compromised life quality and economic burden to the US healthcare system. SPECT MPI is widely utilized for diagnosing, management and predicting outcomesof patients with CAD. Recent studies applying attenuation and spatial resolution correction (ACR) to SPECT have significantly improved these cli ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Enhanced Optical Module to Enable Polarized 129Xe MRI Use in Clinical Trials

    SBC: POLAREAN, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): There are now 50+ new drugs in Phase II-III development to treat COPD - a disease affecting 13 million Americans, costing 49B and killing 120,000 each year. However, a major limitation in evaluating therapies for thesechronic diseases is the lack of a sufficiently sensitive and non-invasive method for drug developers to see efficacy on timescales of days rathe ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Non-Contact Point of Care Device for Sleep Studies

    SBC: INNOVATIVE DESIGN LABS INC            Topic: NHLBI

    DESCRIPTION (provided by applicant): This project will develop non-contact wireless technology that detects the breathing movements of a human chest while covered with pajamas and bed covers. This technology would be a significant improvement to methods used in point of care monitoring outside of a sleep lab. Typical methods of breathing monitoring for a sleep study rely on chest effort belts. Doi ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Automated POC Extraction of Sputum-Borne Bacterial Nucleic Acids In the Clinic

    SBC: WAVE 80 BIOSCIENCES, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Sputum is an increasingly promising noninvasive matrix for diagnosing and monitoring patients with lung conditions. Tuberculosis drug resistance is determined by culture or molecular analysis of bacteria in sputum; lungcancer cells can appear in sputum as an early indicator of disease; absence of bacteria in sputum is a rule-out criterion for broad-spectrum ant ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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