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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

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Displaying 202171 - 202180 of 207728 results
  1. VACCINE: AUTO-IMMUNE DESTRUCTION OF TRANSPLANTED ISLETS

    SBC: CORIXA CORPORATION            Topic: N/A

    Not Available The goals of this program are to design, fabricate and test a readout integrated circuit (ROIC) specifically designed for use with Quantum Well Infrared Photodetector (QWIP) arrays and to incorporate the advanced signal processing requirements needed for Third Generation FLIRs. QWIP photodetector arrays are fabricated from large bandgap materials (GaAs/AIGaAs) which are easily grown ...

    SBIR Phase I 1999 Department of Health and Human Services
  2. VACCINE DELIVERY SYSTEM FOR LIVE ROTAVIRUS VACCINES

    SBC: Secretech, Inc.            Topic: N/A

    THE LONG-TERM OBJECTIVE OF THIS STUDY IS THE DEVELOPMENT OF AN EFFECTIVE DELIVERY SYSTEM FOR A LIVE HUMAN ROTAVIRUS VACCINE. TO AVOID THE INACTIVATION OF VIRUS BY GASTRIC ACID, DIFFERENT BUFFERS ARE BEING GIVEN BEFORE VACCINATION IN CURRENT VACCINE TRIALS. THIS PROJECT FOCUSES ON THE IMPROVEMENT OF THIS TIME- AND COST-CONSUMING PRESENT VACCINEADMINISTRATION PROCEDURE. TO EVALUATE THE EFFICACY OF D ...

    SBIR Phase II 1992 Department of Health and Human Services
  3. VACCINE DELIVERY SYSTEM FOR LIVE ROTAVIRUS VACCINES

    SBC: Secretech, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1990 Department of Health and Human Services
  4. Vaccine discovery for Burkholderia via protection screen

    SBC: MACROGENICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Glanders is a severe disease that has already been used as a bioweapon. It is naturally an equine disease but can be administered by aerosol for efficient human infection. Even if quickly diagnosed as Burkholderia mallei and treated, antibiotics do not control infections well. No vaccine has been developed, yet is a rational component of any plan for defense. I ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  5. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation

    SBC: CERUS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Delayed reconstitution of antigen-specific immunity following allogeneic hematopoietic stem cell transplantation (HSCT) predisposes patients to opportunistic infections and tumor recurrence. To address these problems, we are developing a vaccination methodology using a non-replicating but highly immunogenic Listeria monocytogenes (Lm) vector. When an Lm vaccine ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  6. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation

    SBC: CERUS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Delayed reconstitution of antigen-specific immunity following allogeneic hematopoietic stem cell transplantation (HSCT) predisposes patients to opportunistic infections and tumor recurrence. To address these problems, we are developing a vaccination methodology using a non-replicating but highly immunogenic Listeria monocytogenes (Lm) vector. When an Lm vaccine ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  7. Vaccine enhancement through antigen targeting

    SBC: Iterative Therapeutics Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): There is currently a great need for new and more effective vaccines. Vaccines based on recombinant proteins, purified subunits, or peptides often elicit poor immune responses resulting in a failure to achieve vaccination. Our solution is to develop more effective vaccines that target antigens to antigen presenting cells more directly. In this Phase I proposal ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  8. Vaccine enhancement through antigen targeting

    SBC: Iterative Therapeutics Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): There is currently a great need for new and more effective vaccines. Vaccines based on recombinant proteins, purified subunits, or peptides often elicit poor immune responses resulting in a failure to achieve vacc

    SBIR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  9. VACCINE FOR INFECTIOUS BURSAL DISEASE VIRUS

    SBC: Syntro Corp.            Topic: N/A

    THE IMMUNODOMINANT ANTIGEN OF INFECTIOUS BURSAL DISEASE VIRUS HAS BEEN SHOWN TO BE A 32 KD STRUCTURAL PROTEIN. MONOCLONAL ANTIBODY, DIRECTED AGAINST THE PROTEIN, PASSIVELY PROTECTS CHICKS. SYNTRO HAS CLONED THE ENTIRE LARGE GENOMIC RNA SEGMENT WHICH CODES FOR A SINGLE LARGE POLYPROTEIN THAT IS PROTEOLYTICALLY PROCESSED IN VIVO TO YIELD THE 32 KD ANTIGEN AND TWO OTHER PROTEINS. SYNTRO WILL CONSTRUC ...

    SBIR Phase II 1988 Department of Agriculture
  10. VACCINE FOR INFECTIOUS BURSAL DISEASE VIRUS

    SBC: Syntro Corp.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Agriculture
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