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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 202201 - 202210 of 207728 results
  1. Development of novel rat models for site-specific transgene integration

    SBC: APPLIED STEMCELL, INC.            Topic: NIGMS

    The goal of this proposal is to develop novel rat strains that can be used to efficiently generate site-specific transgenic rat models via pronuclear microinjection. The laboratory rat (R. norvegicus) is a central experimental animal in several fields of biomedical research, such as cardiovascular diseases, aging, infectious diseases, autoimmunity, cancer models, transplantation biology, inflammat ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. High Throughput Data Collection Software for Multiplexed TEM Samples

    SBC: NANOIMAGING SERVICES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Transmission electron microscopy is a valuable technique for characterizing biological therapeutics, vaccines, drug delivery vehicles, and nanoparticles. There is considerable evidence that links the physical propertiesof these samples to their bio-distribution, safety, and efficacy. TEM imaging allows direct observation and quantification of these parameters, ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Detachable Nozzle Piezoelectric Dispense System for Cryo-TEM Sample Preparation

    SBC: ENGINEERING ARTS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Project Summary / Abstract Engineering Arts (EA) proposes the development of a detachable nozzle piezoelectric dispense system for use in Cryo-TEM (Cold - Transmission Electron Microscopy) sample preparation instrumentation. Cryo-TEM is an important tool for studying the structure of biological macromolecules in their native aqueous state. The challenging and l ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Modeling disease in swine by transplantation of gene targeted germ cells.

    SBC: Recombinetics, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Swine models of human disease will become increasingly important for the development of relevant, preclinical therapeutics. However, the creation of swine congenital disease models is plagued by inefficiencies related to animal development and reproduction. The contemporary method for development relies on somatic cell nuclear transfer (SCNT) of genetically mod ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. An In Vitro Human Small Intestine Tissue Model for Drug Permeation Studies

    SBC: Mattek Corporation            Topic: NIGMS

    DESCRIPTION (provided by applicant): The perioral route for drug administration remains the most convenient way of clinical therapy and is preferred by patients, however, good bioavailability is a necessary characteristic of new candidate therapeutics. A key parameter for determining oral bioavailability is drug transport and permeability across the small intestine (SI) epithelium. Therefore, in ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Cell Targeting Peptides for Isolating Patient Specific Stem Cells

    SBC: BioTime, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The ability of human pluripotent stem cells (hPS) to both self-renew and differentiate into virtually any cell type make them a promising source of cells for drug research and development, toxicity screening, developmental research and cell based therapies. Indeed, the derivation of patient matched cells from induced pluripotent stem cells derived from patient ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Metalloproteinase Inhibitor For Pain and Morphine Tolerance Due To Thermal Injury

    SBC: AQUILUS PHARMACEUTICALS INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Aquilus Pharmaceuticals, Inc. proposes to evaluate the effects of a proprietary matrix metalloproteinase (MMP) inhibitor, AQU-010, for blocking neuropathic pain and morphine tolerance in a thermal injury (TI) rat model.The goals for Phase I are to scale-up the synthesis of AQU-010, determine its oral pharmacokinetics (PK) and target tissue penetration and then ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Engineering cells for concurrent protein drug biosynthesis and polysialylation

    SBC: Glycobac, LLC            Topic: NIGMS

    Project Summary / Abstract Therapeutic proteins, or biologics, represent a 100 billion market that includes drugs such as antibodies, hormones, and many others. The clinical efficacy of biologics is critically determined by their circulating half-lives.Hence, various methods have been developed to increase their circulating half-lives by reducing clearance rates. This is commonly achieved by che ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a fluorescence liposomal ABCG2 Multidrug Transporter assay

    SBC: GLSynthesis Inc.            Topic: NIGMS

    ABSTRACT In this project we propose to exploit the recent successful isolation and reconstitution of the important ATP- dependent drug efflux transporter, ABCG2 (BCRP, Breast Cancer Resistance Protein), and combine it with a new transport assay system, the Fluorosome platform, to characterize the interaction of ABCG2 with drugs and drug candidates. The result will provide a useful, novel, highly ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Oligonucleotide Inhibitors of DNA Methyltransferases

    SBC: METHEOR THERAPEUTICS CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): In this Phase I project Metheor Therapeutics is proposing a unique approach to developing novel DNA methyltransferase (DNMT) inhibitors, testing the concept of a substrate trap designed to capture and deplete the enzyme. Inhibition of DNMT activity is a validated therapeutic approach for Myelodysplastic Syndrome and Acute Myeloid Leukemia. Two nucleoside analog ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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