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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 202231 - 202240 of 207712 results
  1. Adjuvant Development for a Thermostable Respiratory Influenza Vaccine

    SBC: UNIVERSAL STABILIZATION TECHNOLOGIES, INC.            Topic: NIAID

    The objective of the proposed project is evaluation of two novel non aluminum vaccine adjuvantsCpG ODN and AdVaxinulin polysaccharidewith intranasal delivery of thermostable live attenuated influenza vaccineLAIVand irradiation inactivation inactivated influenza vaccineIr IIVpowdersThe proposal aims to formulate thermostable vaccines in the dry powder format using patented Preservation by Vaporizat ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Diagnostics to enable malaria and neglected tropical diseases

    SBC: NANOCOMPOSIX, INC.            Topic: NIAID

    Onchocerciasis affectsmillion people worldwidepredominantly in sub Sahara Africaand is a major cause of irreversible blindness among adultswith serious socioeconomic consequencesThe proposal s objective is to develop a simple and inexpensive rapid diagnostic testRDTto detect the presence of two already identified onchocerciasis specific antigens from a finger stick blood sampleThe proposal combine ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Diagnostics to enable Malaria and Neglected Tropical Diseases

    SBC: CROSSLIFE TECHNOLOGIES INC.            Topic: NIAID

    Proposes the development of a paper microfluidics based biosensor for detection of PSSPwhich provides a sensitiverapidelectrochemical based PON techniquecapable of qualitatively and quantitatively detecting PSSPThe proposed product is based on a disruptive platform technology calledD LFB platformwhich is a novelpaper based analytical devicecomposed of the LFAlateral flow assaycomponent and the ECe ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. The objective of this contract is to develop an HIV latent reservoir assay using a microwell array consumable.

    SBC: CELL MICROSYSTEMS INC            Topic: NIAID

    A critical remaining challenge toward a true cure for HIV is understanding how latently infected cells evade the immune system and persist as lifelong viral reservoirsOne eradication strategythe so calledshock and killapproachrelies on cell activating compounds to reverse latent infectionand subsequent antiretroviral therapy to eradicate newly activated cellsHoweverthese compounds activate only a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. The purpose of this contract is to evaluate and modulate the molecular pathways involved in regulating and enhancing HIV envelope/antigen expression in mammalian cell lines and to accelerate development of purification platforms in a cGMP manufacturing se

    SBC: ANTAGEN BIOSCIENCES INC            Topic: NIAID

    HIVthe virus that causes AIDSis one of the world s most serious health and development challengesAccording to UNAIDSthere were approximatelymillion people worldwide living with HIV AIDS at the end ofThe vast majority of people living with HIV are in lowto middle income countriesparticularly in sub Saharan AfricaA low cost vaccine is the preferred response to protect the human populationHoweverdesp ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. The purpose of this contract is to identify several cellular factors that have a major impact on production of a full-length HIV-1 envelope trimer without altering its native antigenic properties.

    SBC: CODEX BIOSOLUTIONS            Topic: NIAID

    million adults and more thanchildren become infected with HIV each yearAn effective HIV vaccine is a one time intervention that is extremely cost effective compared with the cost of lifelong treatmentThe classical vaccination approaches that have been successful in the control of various viral diseases by priming the adaptive immunity to recognize the viral envelope proteins have failed in the cas ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Developing informatics tools to make immunology research data Findable, Accessible, Interoperable and Reusable

    SBC: Melax Technologies, Inc            Topic: NIAID

    Immunological research produces complex datasets ranging from molecular level to individuals and populationsSeveral data repositories aim to serve the community by housing and making the datasets available for reuseHowevertheir usage is still limited due to lack of standardizations and accessibilityOne common issue is that the datasets in these repositories are not available to generalized search ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Diagnostics to enable Malaria and Neglected Tropical Diseases

    SBC: HDT BIO CORP            Topic: NIAID

    The role of HDT Bio is to translate discovery into products for infectious diseasesIn this proposal we focus on producing a diagnostic test to aid in the elimination of leprosyWe will develop LepReactan improved and cost effective diagnostic intradermal skin test to permit screening for Mycobacterium leprae infectionLeprosy is a severe neurological disease caused by infection with Mlepraeand devel ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. A Novel Adjuvant-based Probiotic Platform for Generating Tolerance Therapeutics

    SBC: VIRTICI LLC            Topic: NIAID

    Autoimmune and allergic diseases affect overof the world population and are continuing to riseOur goal is to develop a novel adjuvant based probiotic platform to rapidly create tolerance inducing therapeutics for the treatment of allergy and autoimmune diseaseFor thiswe will leverage the reovirus protein sigmapwhich is a powerful tolerance adjuvantFusion proteins consisting of pwith an antigen of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. The objective of this contract is to develop a novel LBL RNA vaccine that can be administered to induce long-lasting protection against HIV challenge.

    SBC: LUNA INNOVATIONS INCORPORATED            Topic: NIAID

    Extensive efforts have gone towards safe and effective vaccines for Human Immunodeficiency VirusHIVprevention and treatmentAlthough many strategies have been attempted for HIV vaccine developmentnone have been successfully establishedOne category of vaccines gaining increased popularity is RNA based vaccineswhich are vaccines containing antigens encoded by RNA and can be delivered by viral or usin ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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