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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 202261 - 202270 of 207699 results
  1. Validation and Experimentation Toolkit for Spatiotemporal Reasoning (VETS)

    SBC: CHARLES RIVER ANALYTICS, INC.            Topic: N101076

    To maximize the operational value of robotic systems, warfighters must be able to specify high-level commands to direct their autonomous partner’s activities using multiple interaction methods that effectively convey spatiotemporal goals and constraints. The risks involved with unintended behaviors by autonomous robots due to dissonance in warfighter and spatiotemporal reasoning could be catastr ...

    SBIR Phase I 2010 Department of DefenseNavy
  2. Validation and humanization of a PET imaging agent that targets PD-L1.

    SBC: Agenus Inc.            Topic: 102

    DESCRIPTION provided by applicant Several strategies have recently shown convincing clinical efficacy by stimulating adaptive immunity for the treatment of cancer Immune checkpoint inhibitors CpIs for example reactivate a patientandapos s own T cells to eliminate tumors by blocking interactions that cause tumor infiltrating lymphocytes TILs to become exhausted CpIs have shown significan ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Validation and Improvement of ISPRI-HCP: An Innovative Platform for Immunogenicity Risk Assessment of Process-related Protein Impurities

    SBC: EPIVAX, INC.            Topic: NIAID

    ABSTRACT The identification and removal of process-related protein impurities (PRPI) from biologic products is a critical step in drug development. Despite recent improvements in the purification and processing of biologics, the presence of immunogenic PRPI continue to raise concerns about drug safety and efficacy. We propose an innovative approach for assessing immunogenicity risk of PRPI using o ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Validation and numerical testing of turbine augmentors combustion computational modeling

    SBC: FICS, LLC            Topic: N/A

    "This proposed Phase II modeling effort is designed to improve the accuracy of numerical predictions of military gas turbine augmentors through a coordinated program of physics-based modeling improvements within the selected, state-of-the-art ComputationalFluid Dynamics (CFD) flow solver (named FP-Augmentor), and a concurrent test program to provide essential validation data for key models. The ma ...

    SBIR Phase II 2002 Department of DefenseAir Force
  5. Validation and Numerical Testing of Turbine Augmentors Combustion Computational Modeling

    SBC: FICS, LLC            Topic: N/A

    Technical Abstract: The objective of this proposal is to demonstrate the feasibilityof integrating numerical testing with benchmark measurements for developing a validated accurate numerical code for turbine augmentor combustion modeling.1- Feasibility of using our FPVortex code, that has been used in similar applications with proven record, for additional simulations will be studied. The code wil ...

    SBIR Phase I 2001 Department of DefenseAir Force
  6. Validation and qualification of an ex vivo human cardiac tissue-based assay for t

    SBC: ANABIOS CORPORATION            Topic: NCATS

    DESCRIPTION (provided by applicant): Drug-induced cardiac toxicity and adverse events remains a major challenge for both industry as well as regulators. The current strategies for early identification of these potential liabilities in the drug discovery and development process involves a combination of in vitro and in vivo assays, followed by an extensive ECG-based cardiac repolarization study whi ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Validation and qualification of an ex vivo human cardiac tissue based assay for the assessment of the potential cardiotoxicity of pharmaceutical compounds

    SBC: ANABIOS CORPORATION            Topic: NCATS

    PROJECT SUMMARY Drug induced cardiac toxicity and adverse events remain a major challenge for both industry as well as regulators The current strategies for early identification of these potential liabilities in the drug discovery and development process involves a combination of in vitro assays animal models and an extensive ECG based cardiac repolarization study which is conducted on human su ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Validation and Quantification of FFPE Antigen Retrieval by Proteome Analysis

    SBC: CALIBRANT BIOSYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Because of the long history of the use of formalin as the standard fixative for tissue processing in histopathology, there are a large number of archival formalin-fixed and paraffin-embedded (FFPE) tissue banks worldwide. These FFPE tissue collections, with the attached clinical and outcome information, present invaluable resources for conducting retrospective ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  9. VALIDATION AND QUANTIFICATION OF FFPE ANTIGEN RETRIEVAL BY PROTEOME ANALYSIS

    SBC: CALIBRANT BIOSYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Because of the long history of the use of formalin as the standard fixative for tissue processing in histopathology, there are a large number of archival formalin-fixed and paraffin-embedded (FFPE) tissue banks worldwid e. These FFPE tissue collections, with attached clinical and outcome information, present invaluable resources for conducting retrospective pro ...

    STTR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  10. Validation and Quantification of FFPE Antigen Retrieval by Proteome Analysis

    SBC: CALIBRANT BIOSYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Because of the long history of the use of formalin as the standard fixative for tissue processing in histopathology, there are a large number of archival formalin-fixed and paraffin-embedded (FFPE) tissue banks worldwide. These FFPE tissue collections, with the attached clinical and outcome information, present invaluable resources for conducting retrospective ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
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