You are here

Award Data

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 202291 - 202300 of 207712 results
  1. Antibody Fragments to Improve HIV gp120 Protein Production

    SBC: ABZYME THERAPEUTICS LLC            Topic: NIAID

    Camelid single domain antibody fragmentsVHHpossess a number of distinctive features including a small sizean elevated stabilityand an ability to recognize epitopes non accessible for conventional antibodiesBesides common research and immunotherapy applicationscamelid VHHs are also used as co crystallization chaperonesprotein aggregation controllers and enzyme activity tunersIn this proposalwe wish ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. DNA Based Nanoparticle Platform for HIV Env Presentation

    SBC: PARABON NANOLABS, INC.            Topic: NIAID

    In this projectParabon NanoLabs and The Scripps Research Institute propose to develop and produce an effective HIVvaccine using a structured DNA origami nanocarrier for the targetedcontrolled delivery of a stabilizedtrimeric HIVenvelope glycoproteinEnvwith an integrated adjuvantThe project will begin with the synthesis and characterization of composite nanostructurePV NFLto include development and ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A Liposomal Platform for Spontageous, Particleized Presentation of HIV Trimer Immunogens

    SBC: POP Biotechnologies Inc.            Topic: NIAID

    Over one million Americans andmillion people worldwide are infected with HIVmaking it one of the most pressing public health concerns of our timeUnfortunatelythere are no vaccines available and treatment requires lifelong anti retroviral therapiesThis proposal combines two technologies for the development of a vaccine against HIVEnva novel adjuvantspontaneous nanoliposome antigen particleizationSN ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Increased Expression of an HIV CJ505.664 SOSIP Envelope in Plants by Modulation of ER Chaperones

    SBC: Plant Vax, Inc.            Topic: NIAID

    The recombinant HIV SOSIP EnvelopeEnvtrimer is the leading HIV vaccine candidate but current production levels are low in mammalian cell lineslikely due to current trimer designs which include numerous disulfide bondsproteolytic cleavage and extensive glycosylationknown to induce endoplasmic reticulumERstress and cellular toxicityThis proposal will utilize the Nicotiana benthamiana pN bpplant expr ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. A smartphone-based point-of-care test for detection of influenza in low resource settings

    SBC: LUMINOSTICS INC            Topic: NIAID

    Each yearinfluenza causes more thanhospitalizations and aboutdeaths in the U SPeriodicallypandemic strains of influenza emerge that cause even greater devastationthe most recent H Npandemic ofcausingdeaths in the U SDiagnostic testing for influenza is a critical component in managing the diseaseit offers data used in global influenza surveillance efforts and can help guide the treatment of individ ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A Rapid Nucleic Acid Test for the Point of Care Detection of Malaria

    SBC: CROSSLIFE TECHNOLOGIES INC.            Topic: NIAID

    We propose the development of a highly sensitivesimple paper strip molecular nucleic acid blood test that detects parasites causing malaria at the point of careThe final product to be developed in Phaseis an FDA approved nucleic acid based diagnostic device paper dipstick test that contains a multiplex of probe that can amplify and detect nucleic acid sequences from the gametocyte specific pfstran ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. FAST-CMV: A Point-of-Care Cytomegalovirus Serodiagnostic and Avidity Assy

    SBC: LUNA INNOVATIONS INCORPORATED            Topic: NIAID

    Congenital cytomegalovirusCMVinfection is the leading cause of permanent disabilitiescognitive impairmentand sensorineural hearing loss to newbornsMaternal infections that occur during pregnancy and symptomatic congenital CMV infections have been correlated with the most severe complicationsClinical trials are currently evaluating safety and immunogenicity of diverse vaccine candidates driven by t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A Low Cost Integrated Method for Isolation of M. Tuberculosis DNA from Raw Sputum

    SBC: AKONNI BIOSYSTEMS INC            Topic: NIAID

    Nucleic acid testing offers the potential to improve tuberculosis diagnosis world wideHigh purity DNA is essential to the success of virtually any downstream nucleic acid detection methodWe propose to develop a sample preparation system to extract and purify Mycobacterium tuberculosis DNA from raw sputumThe project goalas described in the solicitationPHSTopicis to develop an inexpensive and easy t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a Prophylactic Onchocerciasis Vaccine

    SBC: PAI LIFE SCIENCES INC            Topic: NIAID

    Humanriver blindnessis caused by a filarial parasite and is a serious neglected tropical disease contributing to blindnessskin diseaseand chronic disability in the developing worldEstimates from the Global Burden of Disease Studyindicate thatmillion cases of onchocerciasisleading tomillion cases of vision impairmentoccur worldwide every yearThe goal of this project is to develop a safe and effecti ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Membrane Anchored Cytokines as Novel Vaccine Adjuvants for the Elderly

    SBC: METACLIPSE THERAPEUTICS CORP            Topic: NIAID

    lnterleukinILand granulocyte macrophage colony stimulating factorGM CSFare endogenous immune activatorsEarlier studies using soluble ILand GM CSF as vaccine adjuvants were unsuccessful due to toxicity or suboptimal responseWe developed versions of ILand GM CSF with a glycosylated phosphatidylinositolGPIanchor added at the carboxyl terminusallowing incorporation into lipid bilayers such as in influ ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
US Flag An Official Website of the United States Government