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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 202291 - 202300 of 207714 results
  1. Validation of a Bedside Automated 3D Ultrasound-based Arteriovenous Fistula Cannulation Guidance Solution to Improve AV Fistula Outcomes

    SBC: SONAVEX INC            Topic: 400

    PROJECT SUMMARY/ABSTRACT End Stage Renal Disease (ESRD) impacts 4.3M patients worldwide and accounts for 7% of all Medicare and Medicaid costs. The most prevalent modality of renal replacement, hemodialysis, requires access to the circulation through which dialysis machinery is connected. The preferred method of access is an arteriovenous (AV) fistula as it confers lower rates of mortality, infect ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Validation of a cell-based assay for BoNT/A detection against the mouse bioassay

    SBC: BIOSENTINEL, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Botulinum neurotoxins (BoNT) are the most toxic substances known to humans, causing respiratory failure upon intoxication. Despite their lethality, BoNTs have clinical health and cosmetic applications and are currentlyFDA-approved for treating cervical dystonia, blepharospasm, cranial nerve VII disorders, glabellar lines (wrinkles), and cosmoses. BoNT provides ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  3. Validation of a Cranial Neurosurgery Simulator and Assessment of Minimally Invasive Techniques

    SBC: Simulated Inanimate Models LLC            Topic: 103

    Project SummarySimulation training is unique in its ability for repetitive practice of a wide variety of scenarios and to reflect on performance without jeopardizing a patient s safetySurgical skills simulators have been successful in bridging gaps of the current training modelhoweverthese simulators fall short of offering a complete operative experienceOperative exposure with live patients still ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Validation of a Diagnostic Test for Borrelia miyamotoi

    SBC: L2 DIAGNOSTICS LLC            Topic: NIAID

    ABSTRACT Borrelia miyamotoi is a tick transmitted spirochete recently shown to cause infection and disease in the United StatesEurope and AsiaA member of the relapsing fever group of Borreliathis pathogen has been proven to cause most commonly a nonspecificflu like illness with feverfatiguemyalgiaand headacheDisease can be particularly severe and involve the central nervous system in immunocomprom ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Validation of Advanced Urinary Prosthesis for Improved Urologic Management and Outcomes of Urinary Retention Disorders

    SBC: SPINAL SINGULARITY, INC.            Topic: 300

    PROJECT SUMMARY ABSTRACT The primary objectives of this SBIR Phase II project are to evaluate the safetyeffectivenessand user satisfaction of the Connected Catheter SystemCCSpinal Singularity developed the CC as a fully internalwirelessly controlled urinary prosthesis designed to dramatically improve quality of life for males with urinary retention disorders and to ultimately lower the incidence o ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. VALIDATION OF A HUMAN CD34+ STEM CELL TOXICITY BIOASSAY

    SBC: INTEGRATED LABORATORY SYSTEMS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This SBIR application is submitted in response to the objectives of the NIEHS Predictive Test Systems for Safety Evaluation Program by developing, standardizing, and validating sensitive and specific new and novel test s or batteries of tests . Primary human CD34+ bone marrow stem cells will be used as a novel biological system to identify predictive biomarker ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  7. Validation of a human in vitro system of hepatic steatohepatitis

    SBC: HemoShear Therapeutics, LLC            Topic: 300

    Phase II SBIR Validation of a human in vitro system of hepatic steatohepatitis ABSTRACT Non alcoholic steatohepatitis NASH is part of the progressive disease spectrum of non alcoholic fatty liver disease NAFLD a public health crisis affecting of type diabetics and of obese individuals Glucose and insulin regulated de novo lipogenesis in the liver a critical step in the disease ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Validation of a Human In Vitro Vaginal Irritation Test

    SBC: Mattek Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Exposure of female reproductive tract to the various chemical agents contained within spermicides, medicaments, microbicides, feminine hygiene and other vaginal care products (VCP) can cause inflammation or tissue damage and thus endanger the health of women. Perturbation of the vaginal epithelium by VCP can also increase the risk of acquiring sexually transmit ...

    SBIR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  9. Validation of a Human In Vitro Vaginal Irritation Test

    SBC: Mattek Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): During Phase 1 research, the effects of 6 model test materials on a highly differentiated vaginal- ectocervical (VEC) tissue model were studied. Effects on tissue viability, structure, barrier function, and inflammatory cytokine release were monitored. Many of the assays gave results which supported one another and increased confidence in the in vitro results. ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  10. Validation of a lab-free low-cost screening test for prevention of cervical cancer: automated visual evaluation

    SBC: MobileODT Inc.            Topic: 102

    PROJECT SUMMARY/ABSTRACT Artificial intelligence (AI) has the potential to revolutionize medicine by improving productivity, reducing human error, and assisting with diagnosis and treatment. Image classification algorithms can be used to develop automated visual evaluation (AVE): a potential game-changer for cervical cancer prevention in low- and middle-income countries (LMICs). AVE technology rea ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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