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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 202331 - 202340 of 207728 results
  1. Point of Care Breath Test for Biomarkers of COPD

    SBC: MENSSANA RESEARCH INC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The clinical problem: Chronic obstructive pulmonary disease (COPD) affects an estimated 16 million people in the USA, and it is projected to increase from the sixth to the third most common cause of death worldwide by 2020. COPD imposes a burden on patients by restricting their everyday activities (e.g. walking up stairs), as well as a financial burden on socie ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Manufacturing of Growth Factors to Enable Cardiopoietic Stem Cell Therapy for Hea

    SBC: APT THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Cardiopoietic cell therapy significantly improved left ventricular function, blunted pathological remodeling, and functional outcomes in animal models and Phase I/II clinical trial of heart failure patients. There is ongoing Phase III trial. In this therapeutic approach, bone marrow-derived mesenchymal stem cells are engaged into cardiac stem cells by exposing ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. A prototype diagnostic for cellular fetal hemoglobin in sickle cell disease

    SBC: MyoSyntax Corporation            Topic: NHLBI

    DESCRIPTION (provided by applicant): Sickle cell disease is a major clinical problem in the US, France, the United Kingdom, Brazil, and in Africa, India and the Middle East. A recent study shows that the annual cost of medical care in the US for people whosuffer from sickle cell disease exceeds 1.1 billion. Sickle hemoglobin (HbS) polymerization drives the pathophysiology of this disease. Fetal h ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Patient Breath Simulator for Capnometer Performance Verification

    SBC: WITTING INNOVATION LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Capnometers can fail in a number of ways that are not detectable using current static calibration testing procedures. These failures could include leaks in the sample line, a weak sample pump, inadequate dynamic response, flow restriction and flow obstruction. Failure of a capnometer during critical care procedures such as sedation and anesthesia can be life th ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. FLEXIBLE ADHESIVE PATCH FOR DIAGNOSING SLEEP DISORDERED BREATHING IN CHILDREN

    SBC: SOMNARUS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The objective of this study is to test the feasibility of an innovative flexible skin-adhesive device for diagnosis of sleep apnea in children. Sleep apnea affects up to 6% of the general pediatric population and up to50% of obese children. Childhood sleep apnea causes significant health, developmental and quality of life problems, such as learning deficits, co ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Mixed-reality simulation training for pediatric airway management procedures

    SBC: ARCHIE MD INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Pediatric and neonatal airway management skills are life-saving, difficult to master, and used infrequently enough to make skill maintenance a serious challenge. For example, multiple studies have shown that pediatric and neonatal intubation procedures are often successful less than half of the time, especially among residents. Given the long skill acquisition ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. ReThink HF: A novel multi-parameter sensor for heart failure remote monitoring

    SBC: RETHINK MEDICAL, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Heart failure effects 5.8 million individuals in the US and the costs associated are approaching 40 billion. The current clinical paradigm for managing heart failure patients is reactive and involves patient self-monitoring which suffers from poor compliance. Additionally, patients lack the tools to enable measurements of the relevant physiologic metrics, and ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a microfluidic device for the assessment of hemostatic function

    SBC: HEMOSONICS            Topic: NHLBI

    DESCRIPTION (provided by applicant): The monitoring and management of the hemostatic balance in neonatal and pediatric patients remains challenging. Although several conditions/procedures are known to have great impact in altering hemostatic function in this population, the differences between childhood and adulthood hemostasis make it challenging to determine and monitor the appropriate treat ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Integrated Point-of-Care Diagnostics for Improved Treatment of Neonatal and Pediatric Patients

    SBC: General Fluidics Corporation            Topic: NHLBI

    DESCRIPTION (provided by applicant): The complete blood cell count (CBC) is the most commonly ordered diagnostic test in the ambulatory and emergency room settings. While there are multiple commercially-available point-of-care (POC) systems that measure individual components of a CBC, current systems do not provide the complete CBC but even more importantly, these POC systems do not integrate mult ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Digital Microfluidics- Minimizing blood volume for pediatric coagulation screening

    SBC: BAEBIES, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): It is reported that up to 40% of neonates undergoing cardiac surgery suffer a major thrombosis event. Pediatric patients who are at increased risk for thrombosis due to either congenital or acquired hypercoagulabilityrequire individualized anticoagulation management. Presence of a thrombophilia influences clinical decision making regarding timing and duration ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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