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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 204451 - 204460 of 207728 results
  1. TLR Signal Inhibition: A Novel Therapeutic Paradigm

    SBC: INTERTHYR CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Interthyr Corporation (IC) is requesting an Advanced Technology Phase II STTR award to develop a novel agent with a new therapeutic paradigm: Inhibition of Toll-like receptor (TLR) expression and signaling in non-immune cells. In pursuing studies based on its Phase I award, IC has shown that a lead compound from a family of tautomeric cyclic thiones (TCTs), phe ...

    STTR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  2. High Throughput web-base Image Analysis of Mouse Brain MR Imaging Studies

    SBC: KITWARE INC            Topic: N/A

    DESCRIPTION (provided by applicant): In the last decade, MRI studies of human brain morphometry have been used to investigate a multitude of pathologies and drug-related effects in psychiatric research. The morphometric measures that differentiate patient populations or track longitudinal changes are often subtle and require a large number of subjects or repeated studies to detect and statisticall ...

    STTR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  3. Scanning Chlamydia proteome for vaccine antigens

    SBC: ImmPORT Therapeutics Inc dba Antigen Discovery Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Throughout the World Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen. In areas with poor sanitary conditions C. trachomatis causes trachoma the most common cause of preventable blindness in the World. In symptomatic cases, unless therapy is implemented in a timely manner, long-term sequelae including, pelvic inflammatory disease ...

    STTR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  4. Novel Photoreactive Nanofibers for Bone Regeneration Scaffolds

    SBC: INNOVATIVE SURFACE TECHNOLOGIES INC            Topic: N/A

    DESCRIPTION (provided by applicant): This SBIR project is designed to develop and demonstrate photoreactive nanofibers for tissue engineering scaffolds. Tissue engineering offers the possibility of aiding regeneration of tissue damaged by disease or trauma and, in some cases, of creating new tissue and replacing failing or malfunctioning organs. It is achieved through the use of degradable biomate ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  5. Non-Invasive Drug Delivery to Treat Severe Uveitis

    SBC: ACIONT, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overarching aim of this innovative proposal is to develop and then commercialize a non-invasive topical product which is safe and easy to administer that treats severe uveitis, including intermediate and posterior uveitis. Uveitis is the third leading cause of blindness in the United States. Heretofore, the primary treatments of intermediate and posterior u ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  6. In Vitro Tissue Model of Psoriasis

    SBC: Mattek Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Psoriasis is a chronic, inflammatory, hyper-proliferative skin disease that affects nearly 80 million people worldwide. During Phase 1, cells from involved psoriatic lesions were harvested, proliferated in monolayer culture, and cryopreserved. Culture conditions were identified which allowed the production of a full thickness psoriatic tissue model (PTM). The ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  7. Multiplexed Microarray Detection of Pluripotency Related Proteins

    SBC: PRIMORIGEN BIOSCIENCES INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Primorigen Biosciences will use SBIR funds to develop a frameless, multiplexed, microarray screening system for rapid identification and characterization of antibody matched pairs with appropriate affinity and specificity for human proteins central to pluripotency and multipotency. This system produces improved assay content and dramatically reduces the time an ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  8. Preclinical Development of an Absorbable Antibacterial Bone Hemostatic Agent

    SBC: CEREMED, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): OsteneTM is a soft moldable adhesive material that sticks well to bleeding bone surfaces. It was invented by researchers at USC and CHLA as a replacement for standard bone wax, a beeswax-based material that causes local inflammation and is known to increase the risk of infection after surgery. In contrast, Ostene is a combination of biocompatible water-soluble ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  9. Engineered tissue-based, high-throughput compound profiling

    SBC: Invivosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Heart disease frequently leads to cardiac fibrosis. In almost all cases of chronic heart disease, the myocardium exhibits fibrosis developed by activated cardiac fibroblasts. These fibroblasts are quiescent in the healthy heart. Interstitial fibrosis due to extracellular matrix deposition by fibroblasts increases the stiffness of the tissue and impairs cardiac ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  10. Deep-Submicron Optical Detection for High-Density High-Throughput DNA

    SBC: LIGHTSPEED GENOMICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This project addresses the looming optical detection bottleneck in sequencing by developing an ultra high-throughput 250nm-scale optical scanner. In addition to a 50X gain in throughput, the approach also supports a 4X feature-size reduction path that can help drive down reagent usage by a factor of 16X. Together, these throughput and density gains provide the ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
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