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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 204481 - 204490 of 207700 results
  1. FY20 SBIR PHASE 1 TOPIC #400- TDA RADI-SENSE: ENCAPSULATED NANOPARTICLE OXYGEN IMAGING AGENTS FOR RADIOTHERAPY GUIDANCE

    SBC: TDA RESEARCH, INC.            Topic: 400

    Radiation dose effect is heavily dependent on the oxygen concentration at the tumor site, which is variable due to disorganized vasculature. Hypoxic regions of tumors require a higher radiation dose compared to well oxygenated regions. Paramagnetic probes are oxygen sensitive and probe linewidth and relaxation time can be calibrated to O2 concentration and partial pressure. In animal models it has ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. SBIR PHASE I TOPIC 406 SYSTEM FOR NAVIGATION ASSISTANCE TO PATIENTS (SNAP)

    SBC: STARSHIP HEALTH TECHNOLOGIES LLC            Topic: 406

    Cancer care is becoming more complex each year, making the patient’s path to, and through the care continuum confusing and daunting. Patient-navigation programs for cancer patients have grown in recent years, but their navigation support is fragmented in many ways and often incomplete, lessening their effectiveness. A digital tool to support cancer navigators and patients must be available anyti ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. SBIR PHASE I- TOPIC 402-ARTIFICIAL INTELLIGENCE-AIDED IMAGING FOR CANCER PREVENTION, DIAGNOSIS, AND MONITORING

    SBC: BABEL ANALYTICS LLC            Topic: 402

    Retinoblastoma is a rare pediatric cancer affecting the retina, optic nerve, and brain. Accounting for 6% of all cancers in children under the age of five, it is the world's most common primary intraocular childhood malignancy. While survival rates in the U.S. are high, early detection is pivotal to preserving vision: by the time symptoms present, enucleation is often the only option. This proposa ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. TOPIC 397- MICROFLUIDIC TRANSFECTION PLATFORM FOR RAPID MANUFACTURING OF MRNA CAR LYMPHOCYTE PRODUCTS.

    SBC: CELLFE INC            Topic: 397

    The goal of this project is to demonstrate that our microfluidic technology has the potential to enable the next generation of engineered T cells and lymphocytes for oncologic indications, by demonstrating efficient and scalable transfection of chimeric antigen receptor (CAR) mRNA into αβ T cells; as well as into other lymphocytic carriers such as γδ T, NK and NKT lymphocytes. CAR mRNA T cells ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. FY20 PHASE I SBIR CONTRACT- TOPIC 401- PHASE I SBIR CONTRACT QUANTITATIVE BIOMIMETIC MRI BREAST TISSUE AND TUMOR PHANTOM: TOWARD A COMPREHENSIVE PHA

    SBC: CALIBERMRI INC            Topic: 401

    Research statistics have confirmed that breast cancer early detection saves lives. It is important that the patient is staged properly with the lowest possible side effects (morbidity). The best personalized treatment with almost immediate feedback on efficacy is critical to addressing the spread of breast cancer in a timely manner. Creation of a biomimetic quantitative MRI platform to guide the o ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. TOPIC 412: CHAMP-WARE: CONTINUOUS HEALTH MONITORING AND PREDICTIONS USING A WEARABLES-AGNOSTICS PLATFORM FOR CANCER PATIENTS, PHASE I

    SBC: Intelligent Automation, Inc.            Topic: 412

    Commercially available off-the-shelves (COTS) wearables that objectively track physiological variables offer a rich source of information about a patient’s health to clinicians and oncology researchers, to facilitate early adverse-event detection and subsequent management, which can decrease healthcare costs and improve patient quality of life. The passive, continuously measured data streams gen ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. TOPIC 399 LOCALIZED TREATMENT OF SOLID TUMORS WITH RADIATION TRIGGERED LIPOSOMES.

    SBC: Rejuvenics Technologies LLC            Topic: 399

    Rejuvenics Technologies is developing a patented technology that utilizes localized ionizing radiation to trigger release of chemotherapeutic agents encapsulated inside radio-sensitive liposomes. This first-of-its- kind methodology simultaneously targets radiotherapy and delivery of chemotherapeutics to solid tumors; minimizing toxic exposure to vital organs and potentially enhancing efficacy. In ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. DEVELOPMENT OF PATIENT-DERIVED ANTHROPOMORPHIC BREAST PHANTOMS FOR AUTOMATED OBJECTIVE ASSESSMENT OF BREAST X-RAY IMAGING SYSTEMS

    SBC: MALCOVA INC            Topic: 401

    As long as breast cancer remains a pervasive health concern, the need for ever-improving breast cancer imaging technology will exist. Design changes – to incorporate new hardware technologies or methods – may trigger the need for clinical trials to ensure device safety and assess performance. Conducting a clinical trial is not only expensive, but often takes years for patient recruitment and s ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. SBIR PHASE I TOPIC 402: ARTIFICIAL INTELLIGENCE-AIDED IMAGING FOR CANCER PREVENTION, DIAGNOSIS, AND MONITORING

    SBC: REVEAL BIOSCIENCES, INC.            Topic: 402

    Current diagnostic approaches cannot determine which patients with early prostate cancer are most at risk for progression or recurrence, which leaves patients and physicians in the difficult position of choosing between active surveillance or aggressive therapy based on population risks associated with subjectively assigned Gleason scores. Stratifying patients into high-risk and low-risk groups at ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. SBIR PHASE I TOPIC 402: ARTIFICIAL INTELLIGENCE-AIDED IMAGING FOR CANCER PREVENTION, DIAGNOSIS, AND MONITORING

    SBC: CARINA MEDICAL LLC            Topic: 402

    Image-based evaluation of lymph nodes is an essential step in cancer diagnosis, treatment and monitoring. Current clinical practice mostly uses qualitative or semi-quantitative measures in evaluation and thus suffers from inaccuracy due to intra- and inter-observer variability and increased human efforts. This becomes a more serious issue in head and neck cancers due to the large number of clinica ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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