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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 204651 - 204660 of 207728 results
  1. Development of Vasoactive Therapeutic

    SBC: Azerx, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 30,000 patients per year in the US suffer from subarachnoid hemorrhage (SAH). Although SAH represents only 5-10% of strokes, its impact is proportionally much higher because SAH patients are typically younger (mean age is 50 years) than other stroke patients. Nearly half of SAH patients die from either the initial hemorrhage or secondary compli ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  2. Genetic Assay for Inhibitors of RNA-Protein Interactions

    SBC: ADVANCED GENETIC SYSTEMS, INC.            Topic: N/A

    RNA-protein interactions play critical roles in cellular regulatory processes and in the life cycles of many pathogenic viruses including HIV, hepatitis C, SARS, and West Nile virus, and thus represent attractive targets for therapeutics. We have developed novel cell-based assays to identify drugs that target the RNA-protein interactions. The assays incorporate a system of genetic reporters to acc ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  3. Improved Confocal Microscope: Detection & Functionality

    SBC: Optical Finesse, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): A low-cost modification package will be developed to enhance the sensitivity of a standard confocal microscope and to upgrade its functionality as a tool for studying biological specimens. Replacing analog detectors with photon counting devices will improve signal-to-noise ratio. Digital detection through a confocal port will enable fluorescence correlation spe ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  4. Novel Interactive Cell-phone tech for Health Enhancement

    SBC: Palaistra Systems, Inc.            Topic: N/A

    The burden of chronic disease in the United States is formidable, with 70% of all deaths attributable to some form of chronic illness. As the majority of chronic diseases arise from, and vary in severity with, modifiable behaviors, self-care has enormous potential to ameliorate their course; however, adherence to self-care plans is often poor. Advances in technology can empower patients in novel w ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  5. Cell-Based, Chronic Wound Gene Therapy for Older Adults

    SBC: Stratatech Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): According to the Wound Healing Society, about 15% of older adults in the United States suffer from chronic, hard-to-heal skin wounds. An increase in proteolytic activity is associated with intrinsic cutaneous aging predisposing the elderly to tissue breakdown. Furthermore, chronic wounds inherently exhibit a highly proteolytic environment resulting in abnormal ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  6. Optimal Hydrophobicity of Lipoid Gene Delivery Agents

    SBC: AVANTI POLAR LIPIDS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Cationic lipid-like compounds are commonly used in vitro and in vivo to deliver DNA to cells for the purposes of expressing exogenous genes. A number of clinical trials have indicated the promise of these agents for gene therapy, however lipid-based delivery remains less effective than the alternative viral vectors. Nevertheless, vast improvements have been mad ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  7. Feasibility of Dual Use Module for Major Depression

    SBC: Psychiatric Assessment Systems            Topic: N/A

    DESCRIPTION (provided by applicant): Each year, only 10-20% of 18.5 million Americans with depression receive appropriate, effective care. Psychiatric Assessment Systems (PAS) seeks to address poor quality of care for this common, debilitating disorder by developing a tool to help psychiatrists more effectively treat patients with depression. Psychiatrists have little incentive now to use clinical ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  8. Prolyl endopeptidases to treat Celiac Sprue

    SBC: DNA Twopointo Inc            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this proposal is to engineer enzyme candidates suitable for the treatment of Celiac Sprue. Celiac Sprue is a widely prevalent immune disease of the small intestine induced by dietary gluten in genetically susceptible individuals. By damaging the intestinal villi, Celiac Sprue causes a range of symptoms, including diarrhea, iron and vitamin deficienc ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  9. DNA helicase and primase inhibitors for biodefense

    SBC: MICROBIOTIX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term goal of this project is to identify specific inhibitors of B. anthracis helicase and primase and develop them into novel antibiotics for bio-defense. New antibiotics based on novel chemical scaffolds are vital to the bio-defense armory because they are likely to be effective against both natural and engineered resistant forms of bio-terrorist agen ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  10. Administrator's Guide to RY Implementation

    SBC: RECONNECTING YOUTH COMPANY            Topic: N/A

    DESCRIPTION (provided by applicant): Our long-term goal is to enhance the implementation fidelity of Reconnecting Youth [RY(r)], a NIH/SAMSHA model prevention program. Implementation failures of model programs include unrecognized, persistent structural features, poor management, meager attention paid to the adults who lead and carry out the program. Hence, we focus on innovative ways to prepare a ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
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