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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 204651 - 204660 of 207728 results
  1. IGF OT IGF TRANSCATHETER CAVOPULMONARY BYPASS ENDOGRAFT SBIR TOPIC DIRECT TO PHASE II IGF OT IGF

    SBC: TRANSMURAL SYSTEMS LLC            Topic: NHLBI

    Extra anatomic bypass or vascular shunts divert blood flow In congenital heart disease these surgical procedures are critical for management Children born with one functional ventricle or cardiac pumping chamber require two to three major cardiac surgery procedures for palliation The management goal is to divert systemic venous return deoxygenated blood from the heart directly to pulmonary a ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. IGF OT IGF MULTIPLEXED HIGH CONTENT ASSAY FOR TOXICITY MECHANISMS AND PHENOTYPES IN LIVE IPSC DERIVED CARDIAC CELLS

    SBC: CAIRN BIOSCIENCES INC            Topic: NIDA

    Toxicological assessments rely on low throughput costly animal studies that deliver minimal insights into compound toxicity mechanisms Induced pluripotent stem cells iPSCs are positioned to transform the evaluation of toxic compounds by enabling predictive physiologically relevant model systems compatible with high throughput screening Combining these iPSC benefits with high content screenin ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. IGF OT IGF SBIR PHASE I TOPIC CELL BASED MODELS FOR PROSTATE CANCER HEALTH DISPARITY RESEARCH

    SBC: Shuttle Pharmaceuticals, Inc.            Topic: NCI

    Prostate cancer health disparities studies have shown that African American AA men are athigher risk for developing prostate cancer as well as at higher risk of cancer specific death ratesas compared to Caucasian American CA men The causes of disparities have been attributedto socioeconomic differences environmental exposures and biological factors Most disparitiesstudies have been populat ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. IGF OT IGF ESTABLISHMENT OF CANCER CELL LINES FOR ADVANCING OVARIAN CANCER HEALTH DISPARITY RESEARCH

    SBC: Tatva Biosciences, LLC            Topic: NCI

    Ovarian cancer OC disproportionately affects the women of African American AA background at all stages of the disease from presentation through treatment Most upsetting fact is that AA patients have greater mortality and their survival rates are continuously decreasing as compared to Caucasian American CA Success in understanding and characterizing the involved mechanisms in existing rac ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. IGF OT IGF SBIR PHASE I TOPIC COMPACT CELL FREE DNA DETECTION ARRAY

    SBC: NANOHMICS INC            Topic: NCI

    Cell free nucleic acid cfNA biomarkers circulating in the blood have the potential to serve as simple rapid and non invasive diagnostic indicators As such cell free biomarkers have emerged in the forefront of cancer diagnostic research with the promise of improved disease state prognostication therapy resistance monitoring and metastasis or recurrence determination using a simple blood test ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. IGF OT IGF SBIR PHASE I TOPIC CTDNA DIAGNOSTIC ENABLED BY MAGNETIC AUTOMATION ASSAYS

    SBC: NVIGEN            Topic: NCI

    Circulating tumor DNA ctDNA is a promising biomarker for noninvasive diagnostic prognostic and follow up tests for cancer However the relatively low quantity of ctDNA and the rare cancer mutations within large excess of wild type DNAs have presented many challenges for its application in the clinic The goal of the research is to develop our magnetic nanobeads and highly fluorescent magnet ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. GENETIC CYTOLOGY FOR SURVEILLANCE OF RECURRENT BLADDER CANCER

    SBC: PAPGENE, INC.            Topic: NCI

    This proposal details the development of UroSeqS as a genetic cytology test to extend the utility of routinely collected urine specimens to the detection of recurrent bladder cancer UroSeqS is a genetic cytology assay that achieves sensitivity and specificity through identifying DNA mutations causative of cancer from routinely collected clinical specimens An innovative approach is used toanalyz ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. IGF OT IGF PROXIMITY DNA EXCHANGE IMAGING

    SBC: Ultivue, Inc.            Topic: NCI

    A great challenge in microscopic imaging of biological and medical samples e g tissue sections is to achieve high sensitivity high specificity high multiplexing and high resolution preferably beyond the diffraction limit simultaneously This SBIR proposal addresses this challenge by developing a novel technology platform called Proximity DNA Exchange Imaging As a result of the studies pro ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. IGF OT IGF MIND CAP MONITORING FOR COGNITIVE IMPAIRMENT AND DYSFUNCTION IN CANCER PATIENTS

    SBC: Intelligent Automation, Inc.            Topic: NCI

    IAI with our partner NTI proposes to develop the MIND CAP system Monitoring cognitive Impairment and Dysfunction in Cancer Patients We will employ a quantitative approach to select existing cognitive tests from the clinical literature that are sensitive enough to detect cognitive decrements in the domains most relevant to the breast cancer population In collaboration with our expert panel of ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. IGF OT IGF PREDICTIVE BIOMARKERS OF PROSTATE CANCER PATIENT SENSITIVITY FOR RADIATION LATE EFFECTS

    SBC: Shuttle Pharmaceuticals, Inc.            Topic: NCI

    Patients treated for prostate cancer may experience treatment related late effects thatadversely affect quality of life and may prove life threatening The objective of this Phase I SBIRapplication is to determine the technical and commercial feasibility of a biomarker panelpredictive of radiation mediated late effects in patients treated for prostate cancer We willdevelop a metabolite signature ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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