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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 204841 - 204850 of 207728 results
  1. First-in-class ETS inhibitor TK216: Translational Biology and Oral Dosage Form Development

    SBC: ONCTERNAL THERAPEUTICS, INC.            Topic: 102

    TK216 is an investigational, potentially first-in-class, targeted small molecule that is designed to specifically inhibit the biological activity of the ETS family of oncoproteins. Tumorigenic gene fusions involving ETS factors are frequently found in tumors, such as Ewing sarcoma (ES) as well as childhood leukemias and prostate cancer. ETS factors are also often overexpressed in other tumors, suc ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  2. A Home Exercise Program (DVD) for Women with Infants and Young Children

    SBC: KLEIN BUENDEL, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): Becoming a mother is a significant transition in a woman's life. This transition can precipitate major changes in health behaviors, like physical activity. Once a woman has a child she is much less likely to participate in regular, moderate to vigorous physical activity compared to women without children. Thus, new mothers are at risk for future weight gain and ...

    STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  3. Validation of a Negative Regulator as a Novel Therapy for Autoimmune Disease

    SBC: Immunext, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Systemic lupus erythematosus SLE is a devastating autoimmune disease that most commonly affects women in their child bearing years SLE attacks multiple organ systems but renal and neurologic involvement are the usual harbingers of poor outcome Despite effective albeit toxic immunosuppressive therapy only of patients with these serious manifestations ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a Precision Medicine-based Diagnostic Tool for Membranous Nephropathy

    SBC: Nephropathology Associates, PLC            Topic: 400

    Project SummaryThe goal of this program is to initiate commercialization of a mass spectrometry (MS)-based workflow for the diagnosis and classification of membranous nephropathy (MN), a leading cause of nephrotic syndrome, leading to kidney failure in a third of patients. Since the 1950’s, most forms of MN were considered idiopathic in origin, however, based on numerous publications in recent y ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Validation of Novel Therapeutic Approach for Leptomeningeal Metastases

    SBC: Minnetronix Medical, Inc.            Topic: 102

    ABSTRACT Leptomeningeal Metastases (LM) is a condition in which tumor cells from a primary tumor metastasize, invade the subarachnoid space (SAS) and spread throughout the cerebrospinal fluid (CSF), resulting in seeding along the meninges, brain and spinal cord. LM represents a devastating event of cancer progression. There are 30,000 cases annually and currently no cure, with average survival of ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Countermeasures to Malicious Hardware to Improve Software Protection Systems

    SBC: Clear Hat Consulting, Inc.            Topic: OSD10IA1

    The availability and low cost of COTS software and hardware components has resulted in their deployment across a wide array of critical defense and industry applications. Clear Hat focused their Phase 1 effort on developing countermeasures for malicious hard disk firmware. Although we will continue our research and development of technologies designed to ensure the integrity of disk drive firmware ...

    SBIR Phase II 2012 Department of DefenseOffice of the Secretary of Defense
  7. Permanent Magnet Motor (PMM) Based Steering Gear for DD(X)

    SBC: ADVANCED ENERGY CONVERSION, LLC            Topic: N03086

    The technical objectives of the Phase II effort are to develop a form, fit, and function specification (FFFS) for steering gear based on permanent magnet motors. A review of available motors will be undertaken in parallel with application-specific design to determine the most practical realization of the steering gear. A test module will be designed and implemented to demonstrate the selected ap ...

    SBIR Phase II 2006 Department of DefenseNavy
  8. Cell-Based Screening for Multi-Functional Chemokine Receptor Modulators

    SBC: PRIMITY BIO, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Chemokine receptors belong to the most druggable class of receptors and modulate immune responses central to a wide variety of disease states ranging from inflammation and autoimmunity to viral infection asthma and cancer making these receptors prime drug targets In spite of their apparent therapeutic tractability numerous clinica trials of seemingly promising com ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  9. Sedationless Multi-View High-Resolution Endoscopy

    SBC: OMNISCIENT IMAGING INC            Topic: 102

    Abstract An upper endoscope is designed for the endoscopic evaluation of the esophagus, stomach and duodenum, however, of the six-million upper endoscopies performed annually in the US, about half are for the disorders of the esophagus alone, where it can be argued that a full endoscopy of these three organs is not necessary in many, particularly since the procedure requires sedation with its asso ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Wearable Device for Continuous Hemodialysis

    SBC: VIVONICS INC            Topic: NIDDK

    DESCRIPTION: The fundamental goal of this program is to develop a microfluidics-based artificial kidney that minimizes exposure of blood to artificial surfaces and provides continuous perfusion in a compact, wearable device. This device will provide treatment at low flow rates over long times, greatly reducing concentration and volume transient in body fluids. The key element is a primary separato ...

    STTR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
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