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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 205011 - 205020 of 207725 results
  1. Development of a high-throughput epigenomic mapping platform to molecularly phenotype Crohn's disease

    SBC: Epicypher, Inc.            Topic: 300

    SUMMARYThe inflammatory bowel diseases (IBDs), Crohn’s disease (CD) and ulcerative colitis (UC), are chronic conditions of the gastrointestinal (GI) tract. CD can occur anywhere along the GI tract and has highly heterogeneous clinical presentation/outcomes, challenging treatment. Further, reliable markers that predict CD course and/or treatment response do not exist. We (and others) have shown t ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Proteomics software package for the detection of cancer

    SBC: INCOGEN, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): In the Phase II of this SBIR project we will develop a modular and extensible exploratory software tool for signal conditioning and data mining of profiling proteomics MS necessary for the development of cancer

    SBIR Phase II 2004 Department of Health and Human ServicesNational Institutes of Health
  3. An H/F/X/Y Fast-MAS NMR Probe Particularly for Alzheimer's and Cancer Research

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    An H/F/X/Y Fast-MAS NMR Probe Particularly for Alzheimer’s and Cancer Research AbstractMore than 20% of current drugs (and a much greater fraction of those in development) are fluorinated (including such block-busters as Prozac, Lipitor, and Ciprobay). Steady progress over the past decade has shown magic angle spinning (MAS) solid-state NMR (ssNMR) to be arguably the most powerful analytical too ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Software for Accurate Ligand-Protein Affinities

    SBC: VERACHEM LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Discovering a compound that will bind a protein therapeutic target with high affinity, while retaining favorable pharmacological properties, can be a time-consuming and expensive bottleneck in the drug-discovery process. Computational methods can speed this ligand discovery step, but are not yet reliable enough to circumvent extensive experimental testing, even ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  5. SRW-UAG Physical Layer Port to JTRS Platform (SBIR II.5)

    SBC: TrellisWare Technologies, Inc.            Topic: N08088

    Teleoperations (or Teleops) is critical to current military tactical needs and so there is an urgent need for enabling technologies and quick deployment. The SRW-UAG PHY has new mission enabling capability such as broadband data rates, discontinuous spectra, and robustness to airborne dynamics and terrestrial multipath. In addition, the SRW-UAG PHY can be quickly deployed using existing JTRS platf ...

    SBIR Phase II 2012 Department of DefenseNavy
  6. Opportunistic Real-Time multimodal Sensor Content Exploitation

    SBC: Systems & Technology Research LLC            Topic: NonDoD

    Systems & Technology Research and subcontractor Vision Systems, Inc. propose to deliver an integrated Multi-Modal Exploitation Environment (M2E2) system that fuses multi-modal data streams from distributed sensors to track and predict High-Value Individuals (HVI) activities, represented as space-time threads. We will expand our Phase I suite of automated plug-ins to include audio processing, multi ...

    SBIR Phase II 2016 Department of DefenseNavy
  7. InflammaGut: a drug-screenable co-culture system using gut-associated lymphocytes and autologous primary human gut epithelium that reports inflammation

    SBC: Altis Biosystems, Inc.            Topic: 300

    Project Summary A broad range of inflammatory gastrointestinal conditions impact millions of people in the United States and abroad. The etiology of the disease is multifactorial and heterogeneous, but the common underlying feature is an overactive immune system. Genetics, environmental factors, age, sex, race and even the composition of bacteria that reside in the gut lumen are associated with ca ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  8. High Performance Energetic Propellant Ingredient Process Research and Development

    SBC: NALAS ENGINEERING SERVICES INC            Topic: N16AT021

    CL-20 is the most powerful conventional explosive known, but its high cost has limited its adoption in a range of potential applications. Par of the challenge in making these materials is the complexity of the reaction used to prepare the polycyclic cage. The complexity of this reaction makes it difficult to have insight into the reaction and to improve it. Additionally, several of the intermediat ...

    STTR Phase II 2018 Department of DefenseNavy
  9. Improving marginal allograft outcomes through cell junction stabilization in transplantation

    SBC: FirstString Research, Inc            Topic: 400

    Project Summary/Abstract: Transplantation is a highly successful therapy for end-stage renal disease but there is a significant shortage of available donor organs that has forced utilization of low-quality kidneys to save patient’s lives. Extending the donor criteria has coincided with a growing appreciate that factors associated with organ donation, procurement and storage greatly affect post-t ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Advanced Solid Rocket Motor Technology for Tactical Missiles

    SBC: KNOBLEY TECHNICAL ASSOCIATES, LLC            Topic: AF112102

    ABSTRACT:Knobley Technical Associates Phase Il Advanced Solid Rocket Motor Technologies for Tactical Missiles program includes design, analysis, development and testing efforts to define and mitigate technical and operational challengesto be investigated and resolved for successful maturation ofthe performance enhancing burn-rate augment highly loaded propellant grain technology for next generatio ...

    SBIR Phase II 2015 Department of DefenseAir Force
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