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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 205021 - 205030 of 207712 results
  1. Development of a Staph Aureus Vaccine

    SBC: BIOLOGICAL MIMETICS, INC.            Topic: NIAID

    Abstract Methicillin-resistant Staphylococcus aureus is often considered the prototype hospital-acquired infection. In spite of the billions of dollars spent on preventive measures, estimates of the incidence are in the hundreds of thousands, with tens of thousands of people per year succumbing to disease in the USA alone. Prophylactic vaccines against S. aureus would have an enormous impact in th ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. High throughput antibody discovery against cell membrane bound target proteins using innovative MOD technology for direct screening in single-cell assays

    SBC: SCRIBE BIOSCIENCES, INC.            Topic: NIAID

    ABSTRACT Scribe Biosciences are leading experts in the field of droplet microfluidics and have developed a best-in-class droplet manipulation platform, Microenvironment on Demand (MOD), that can currently assemble rt100k paired-cell assays in lt3 hours, with proven proof of concept. Using this innovative technology, this SBIR Phase 1 project proposes the development and quantification of assay met ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Mitigation of Radiation Induced Gastrointestinal Syndrome.

    SBC: BCN BIOSCIENCES LLC            Topic: NIAID

    Abstract: Currently RAS has been considered a high value target in cancer drug development considering that over 30 percent of all human cancers – including 95% of pancreatic cancers and 45% of colorectal cancers — are driven by mutations of the RAS family of genes. The first clinical launch of a G12C KRAS inhibitor is Lumakras™ (sotorasib) from Amgen for non-small cell lung carcinoma and Mi ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Development of World's First Fully Human Broad Spectrum Anti-Snake Venom

    SBC: Centivax Inc            Topic: NIAID

    ABSTRACT Snakebite envenoming poses a global risk to human health. For over 125 years, antivenoms have consisted of animal-derived polyclonal serum immunoglobulin G (IgG). In recent decades, IgG digested into antigen-binding fragments Fab(2) has been found to reduce some of the most severe side-effects of non-human antivenom. These antivenoms are obtained by immunizing horses or sheep with individ ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Improving Husbandry and Data Reproducibility Through Automated Health Monitoring in Zebrafish Facilities

    SBC: NEMAMETRIX, INC            Topic: 100

    ABSTRACT / SUMMARYThe zebrafish is an invaluable tool for developing and screening human therapeutics and modeling human diseases. This animal model is strikingly genetically similar to humans, sharing 70% of all human genes (by comparison, mice have orthologs of ~80% of human genes), and 82-90% of human disease-associated genes.Currently, however, zebrafish facilities lack an affordable, precise ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Multiple-order, Automatic mesh generation for multidisciplinary Analysis

    SBC: CFD RESEARCH CORPORATION            Topic: N23AT001

    Multidisciplinary design, analysis, and optimization of hypersonic aircraft require automated adaptive mesh generation across disparate length scales. In the current state-of-the-art, geometry-aware adaptive meshing techniques are still lacking and the such geometric discrepancy can lead to significant errors in the prediction of critical physics, such as shock-boundary layer interaction and fatig ...

    STTR Phase I 2023 Department of DefenseNavy
  7. Toolkit to Produce Common Adaptive Mesh for Virtual Reality-based Multidisciplinary Interactive Design of Naval Aircraft

    SBC: Global Engineering and Materials, Inc.            Topic: N23AT001

    Global Engineering and Materials, Inc. (GEM), along with its team member Professor Ming-Chen Hsu’s research group at Iowa State University (ISU), proposes the development of an innovative and effective octree-based adaptive meshing tool for efficient multi-physics simulations for aircraft design and analysis. The proposed tool is capable of autonomously generating a common mesh from Computer-Aid ...

    STTR Phase I 2023 Department of DefenseNavy
  8. Robust, Automatic Mesh Generation for Multidisciplinary Design of Naval Aircraft

    SBC: SIMMETRIX, INC.            Topic: N23AT001

    Multidisciplinary design, analysis, and optimization (MDAO) is a critical enabling technology for the design of complex systems such as naval aircraft. Using high-performance computing and modern analysis codes, many aspects of naval aircraft, and other, systems can be accurately modeled. However, the generation of the meshes analysis codes need as input is overly time consuming, while it takes su ...

    STTR Phase I 2023 Department of DefenseNavy
  9. Automatic Mesh Adaptation Method for Aero-Thermal-Structural Design

    SBC: SPECTRAL ENERGIES LLC            Topic: N23AT001

    In response to the request for proposal (RFP) STTR topic N23A-T001, describes mesh generation and adaptivity as “significant bottlenecks” for current high-fidelity CFD. While methods for producing high-quality meshes exist, they require nontrivial and frequent human intervention. Moreover, these techniques result in a disconnect between the parametric model and the output mesh representation, ...

    STTR Phase I 2023 Department of DefenseNavy
  10. Advanced Physics Modeling for Gas Turbine Particulate Ingestion

    SBC: COMBUSTION RESEARCH & FLOW TECHNOLOGY INC            Topic: N23AT003

    Ingestion of silicate particles into aircraft gas turbine (GT) engines remains a serious hazard to both commercial and military aircraft. Helicopters and low-flying fixed-wing aircraft in desert environments are exposed to airborne sand particulate. Both commercial and military aircraft can be exposed to runway dust as well as high-altitude volcanic ash. These silicate particulates present a hazar ...

    STTR Phase I 2023 Department of DefenseNavy
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