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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 205031 - 205040 of 207714 results
  1. Targeting SWELL1 Signaling to Treat Obesity-Induced Type 2 Diabetes

    SBC: Senseion Therapeutics, Inc.            Topic: 200

    Project Summary/Abstract More than 100 million Americans currently have diabetes or pre-diabetes, a condition that can lead to Type 2 diabetes (T2D) within five years, and that vastly increases adverse cardiovascular events. T2D is characterized by both a loss of insulin sensitivity of target tissues (fat, skeletal muscle, liver) and ultimately, impaired insulin secretion from the pancreatic b-cel ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Genetic Cytology for Ovarian and Endometrial Cancer Screening

    SBC: PAPGENE, INC.            Topic: 102

    DESCRIPTION provided by applicant In this Fast Track application a path to commercialization will be pursued for a breakthrough andquot genetic cytologyandquot test capable of detecting both ovarian and endometrial cancer from routinely collected Pap specimens In deference to the notable success of the Pap test in reducing deaths due to cervical cancer and in reference to the core enabling ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Multivalent Adjuvant Immunization to Prevent Hospital Acquired Infections

    SBC: EXBAQ LLC            Topic: NIAID

    PROJECT SUMMARY/ABSTRACT Two million Healthcare Associated Infections (HAIs) occur per year in the US, killing rt90,000 patients and costing ~$50-100 billion (adjusted by CPI to 2020 dollars). HAIs are the 6th leading cause of death in the US, ahead of diabetes and kidney disease. Reducing HAIs is a top priority of the US Department of Health and Human Services1 and experts have called for novel s ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  4. First and Only Soft Tissue Support Device to Improve Patient Experience and System Cost in Breast Reconstruction

    SBC: Surgical Innovation Associates, Inc.            Topic: 102

    NOTE: These pages contain proprietary/privileged information. SIA requests that they not be released to personsoutside the Government, except for purposes of review and evaluation. Project Summary/Abstract DuraSorb™ is poised to significantly improve the lives of the over 100,000 US women undergoing post- mastectomy breast reconstruction every year. The current standard of care in implant-based ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. IGF OT IGF RandD NANOEMULSION FORMULATION AND IND ENABLING STUDIES OF A NOVEL CENTER STEM CELL CYTOTOXIC AGENTPERIOD OF PERFORMANCE SEPTEMBER JULY

    SBC: Targagenix, Inc.            Topic: NCI

    The proposed studies will create evaluate and validate the formulation dosing pharmacodynamics cytotoxicity efficacy and toxicology of a nanoemulsion of a novel cancer stem cell CSC cytotoxic drug DHA SBT In vitro and in vivo assays using FACS purified CSCs will be used to assess efficacy to kill differentiated tumor cells and CSCs NE DHA SBT will be administered intravenously ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. CTC Purification System Based on Thermoresponsive NanoSubstrates

    SBC: CYTOLUMINA TECHNOLOGIES CORPORATION, INC            Topic: 100

    DESCRIPTION provided by applicant The goal of this SBIR Phase II proposal is to conduct the advanced development of the rd gen Thermoresponsive NanoVelcro assay in order to achieve rapid purification of circulating tumor cells CTCs from non small cell lung cancer NSCLC patient blood samples paving the way for CTC derived molecular signatures and functional readouts This project is led by ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. A novel protein engineering tool for rapid manufacturing of designer nucleosomes

    SBC: Epicypher, Inc.            Topic: 103

    PROJECT SUMMARYEpiCypher is pioneering the commercial development of fully defined recombinantsemi synthetic nucleosomes carrying specific histone post translational modificationsPTMstermed designer nucleosomes or dNucsTMfor epigenetics researchWe currently use native chemical ligationNCLto generate modified histones for dNuc assemblyand have developed proprietary methods to efficiently manufactur ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. A Reliable Switched Angle Spinning (SAS) Probe with Gradients (PFG) for Proteins in Solid-State NMR

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    A Reliable Switched Angle Spinning (SAS) Probe with Gradients (PFG) for Proteins in Solid-State NMR AbstractSolid-state NMR (ssNMR) biotechnology is emerging as a method of choice for high-resolution structure determination for integral membrane proteins (IMPs). ssNMR provides a unique platform to investigate protein dynamics and functional studies of a wide range of biomolecules in their supramol ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Patient Care Environment through Immersive Virtual Reality

    SBC: CFD RESEARCH CORPORATION            Topic: 20

    To develop an immersive VR environment where clinicians can interact with patients with rare diseases using virtual avatars.

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Novel therapy for alcoholic liver disease-associated hepatorenal syndrome

    SBC: MITOPOWER LLC            Topic: 999

    Novel therapy for alcoholic liver disease-associated hepatorenal syndrome Abstract Alcoholic liver disease (ALD) results in over 400,000 hospitalizations each year in the US, with a portion of these patients developing hepatorenal syndrome with acute kidney injury (HRS-AKI). There are no current therapeutic options that specifically address the cellular dysfunction and systemic inflammatory respon ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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