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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 205041 - 205050 of 207728 results
  1. TOPIC 368: TREATMENT OPTIMIZATION BY COMBINED A-EMITTER (ARPT)/RADIOTHERAPY (XRT) DOSIMETRY FOR PROSTATE CANCER PATIENTS

    SBC: RADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC            Topic: NCI

    We propose to demonstrate a cloud based software service for Combination alpha emitter radiopharmaceutical therapyRPTand external beam radiotherapyXRTCX RPTtreatment planningBoth modalities deliver radiationWe will demonstrate feasibility clinically by collecting the data needed from an existing Hopkins trial evaluating combination XRT with XofigoRa dichlorideanRPT that concentratesparticle radiat ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. TOPIC 359: A DEVICE PROTOTYPE FOR ISOLATION OF MELANOMA EXOSOMES FOR DIAGNOSTICS AND TREATMENT MONITORING

    SBC: Aethlon Medical, Inc.            Topic: NCI

    The proposed work aims to develop a pre commercial prototype of an exosome isolation device to be used in clinical diagnostic laboratoriesWe will advance the device to facilitate exosome isolation for downstream liquid biopsy tests requiring analysis of proteinDNAor microRNAwhich rely upon acquisition of intact and pure exosomesThe device strategy will be designed to isolate total exosomes and the ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. TOPIC 360: A SIMPLE END-TO-END SYSTEM FOR SERIAL CELL SORTING AND MANIPULATION USING A SINGLE CONTAINER- MOONSHOT

    SBC: DIAGNOLOGIX, LLC            Topic: NCI

    Chemotherapy may control but rarely cure metastatic cancersRemarkablymodern immunotherapiesincluding cell based therapieshave cured metastatic melanomas and other types of cancersA major challenge for all cell therapies in general is the need to develop cost effective and efficient manufacturing and delivery capabilitiesWe have recently established an innovative cell isolation technology by applyi ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. TOPIC 343: NEUROPSYCHOLOGICAL ASSESSMENT SYSTEM FOR CANCER PATIENTS

    SBC: CREARE LLC            Topic: NCI

    Cognitive decline is a major quality of life concern for many cancer survivorsThevarious available treatments affect individuals differentlyand research has unfortunately provided little guidance on how specific treatments impact neurocognitive functionTo help researchers fill this information gap and ultimately provide guidance to doctors and patientsa neuropsychological assessment system that is ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. TOPIC 366: I-PARTS INTEGRATED PLATFORM FOR ANTI-CANCER RADIATION THERAPEUTICS SCREENING

    SBC: PACT & HEALTH LLC            Topic: NCI

    Tumor Irradiation during cancer treatment induces clonogenic death that can be best assessed by colony forming assaysThese colony forming assays are laborious and never utilized in high throughput screeningHTSformatsWe propose to develop anintegrated platform for HTS clonogenic survival assayfor cancer drug screening as well as radiation effect modulation screeningNamedI PARTSIntegrated platform f ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. TOPIC 353: HIGHLY ACCURATE LOW COST CTDNA DIAGNOSTICS WITH MAGNETIC NANOPARTICLE ENABLED AUTOMATED SAMPLE PREP- MOONSHOT

    SBC: NVIGEN            Topic: NCI

    The goal of the research is to develop a highly accurateautomatedand low cost ctDNA test to monitor efficacy of treatment of metastatic breast cancer patients by identifying the emergence of certain DNA mutations in plasma samplesThere is growing evidence that the presence of certain DNA mutations in the blood stream correlates with breast cancer becoming resistance to hormone treatmentNVIGEN will ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. TOPIC 345: PREDICTIVE BIOMARKERS OF PROSTATE CANCER PATIENT SENSITIVITY FOR RADIATION LATE EFFECTS

    SBC: Shuttle Pharmaceuticals, Inc.            Topic: NCI

    To address the goals of developing ""predictive biomarkers of adverse reactions to radiation treatment""we propose to perform a multi site analytic validation of the product""metabolite panel kit""developed in the Phase I SBIR effortResults of plasma metabolite analysis in defined cohorts of patients treated with SBRT for prostate cancer will be tested for precisionaccuracy and reproducibility in ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. SBIR PHASE I TOPIC 392: TARGETED RADIONUCLIDE THERAPY OF METASTATIC LIVER CANCER: PATIENT SPECIFIC OPTIMIZATION

    SBC: RADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC            Topic: NCI

    Radioembolization using Ymicrospheres delivered into the hepatic artery under fluoroscopy guidance has slowed tumor progression in the liver for patients diagnosed with metastatic colorectal cancermCRCTreatment planning is based on a simple estimate of the average absorbed doseADdelivered to the treated volumetumor dose thus depends on tumor burden and tumor to background ratioresulting in under d ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. TOPIC 393: INTEGRATED PHOTONIC BIOSENSOR FOR PRECISION ONCOLOGY DOSE MEASUREMENTS

    SBC: INTELLIGENT FIBER OPTIC SYSTEMS CORP            Topic: NCI

    Radiation therapy is a widely used primary treatment for multiple malignanciesHoweverphysical dose measurement is not an effective approach as the biological response of different patients or even different types of cancers are very different for the same physical doseMoreoverdiseased tissue and normal organ radiation sensitivities also varyExisting medical devicesphysical dosimetersdo not satisfy ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. TOPIC 389- INTELLIGENT SOFTWARE FOR RADIATION THERAPY PLANNING

    SBC: RADIASOFT LLC            Topic: NCI

    Besides surgeryradiotherapy is the most effective treatment modality for localized prostate cancerThe success of radiotherapy stems from the exploit of a therapeutic window in tumor response and normal tissue tolerance which maximizes the chance of sterilizing the tumor while sparing the surrounding normal tissue from severe damageThis requires an accurate and individualized radiation dose distrib ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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