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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 205051 - 205060 of 207731 results
  1. IGF OT IGF RandD NANOEMULSION FORMULATION AND IND ENABLING STUDIES OF A NOVEL CENTER STEM CELL CYTOTOXIC AGENTPERIOD OF PERFORMANCE SEPTEMBER JULY

    SBC: Targagenix, Inc.            Topic: NCI

    The proposed studies will create evaluate and validate the formulation dosing pharmacodynamics cytotoxicity efficacy and toxicology of a nanoemulsion of a novel cancer stem cell CSC cytotoxic drug DHA SBT In vitro and in vivo assays using FACS purified CSCs will be used to assess efficacy to kill differentiated tumor cells and CSCs NE DHA SBT will be administered intravenously ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. CTC Purification System Based on Thermoresponsive NanoSubstrates

    SBC: CYTOLUMINA TECHNOLOGIES CORPORATION, INC            Topic: 100

    DESCRIPTION provided by applicant The goal of this SBIR Phase II proposal is to conduct the advanced development of the rd gen Thermoresponsive NanoVelcro assay in order to achieve rapid purification of circulating tumor cells CTCs from non small cell lung cancer NSCLC patient blood samples paving the way for CTC derived molecular signatures and functional readouts This project is led by ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. A novel protein engineering tool for rapid manufacturing of designer nucleosomes

    SBC: Epicypher, Inc.            Topic: 103

    PROJECT SUMMARYEpiCypher is pioneering the commercial development of fully defined recombinantsemi synthetic nucleosomes carrying specific histone post translational modificationsPTMstermed designer nucleosomes or dNucsTMfor epigenetics researchWe currently use native chemical ligationNCLto generate modified histones for dNuc assemblyand have developed proprietary methods to efficiently manufactur ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. A Reliable Switched Angle Spinning (SAS) Probe with Gradients (PFG) for Proteins in Solid-State NMR

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    A Reliable Switched Angle Spinning (SAS) Probe with Gradients (PFG) for Proteins in Solid-State NMR AbstractSolid-state NMR (ssNMR) biotechnology is emerging as a method of choice for high-resolution structure determination for integral membrane proteins (IMPs). ssNMR provides a unique platform to investigate protein dynamics and functional studies of a wide range of biomolecules in their supramol ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Patient Care Environment through Immersive Virtual Reality

    SBC: CFD RESEARCH CORPORATION            Topic: 20

    To develop an immersive VR environment where clinicians can interact with patients with rare diseases using virtual avatars.

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Novel therapy for alcoholic liver disease-associated hepatorenal syndrome

    SBC: MITOPOWER LLC            Topic: 999

    Novel therapy for alcoholic liver disease-associated hepatorenal syndrome Abstract Alcoholic liver disease (ALD) results in over 400,000 hospitalizations each year in the US, with a portion of these patients developing hepatorenal syndrome with acute kidney injury (HRS-AKI). There are no current therapeutic options that specifically address the cellular dysfunction and systemic inflammatory respon ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. A Compact, Rugged, Mobile Automated Identification Technology Integrated Warehouse Scanning System for use in a Military Deployed Environment

    SBC: VERDASEE SOLUTIONS, INC.            Topic: A07145

    A compact, rugged, mobile, integrated automated-identification-technology warehouse system will be designed, built and demonstrated for use in military environments. The system will be scalable and able to provide management and visibility in local, regional and global environments. The system will employ a variety of technologies including active and passive RFID tags; agile scanners able to r ...

    SBIR Phase II 2008 Department of DefenseArmy
  8. Multi-Omic Single-Cell System for Improved Combination Cancer Immunotherapy Monitoring and Implementation

    SBC: ISOPLEXIS CORPORATION            Topic: 102

    IsoPlexis proposes to deliver a novel multi-omic method for targeted profiling of both the TCR sequence and proteome from an array of 1000+ single cells. Specifically, we will deliver a single-cell, TCR sequencing and protein capture assay for identifying responsive antigen specific TCRs, and concurrently evaluate these T-cells for functional response to that antigen. The challenge remains to link ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Detecting breast cancer with a simple blood test using an accessible and low-cost novel real-time platform

    SBC: INANOVATE INC            Topic: 102

    Project SummaryAlthough widespread screening by mammography has successfully cut mortality from breast cancerBCathe exquisite sensitivity of the technique results in a startling number offalse positivesOf approximatelymillion women who receive a positive mammogram each yearfewer thanwill be diagnosed with BCaCumulativelythe economic cost of followup diagnostics to resolve falsepositive mammograms ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Renalase: Development as an Innovative New Drug for Acute Pancreatitis

    SBC: BESSOR PHARMA, LLC            Topic: 300

    Project Summary/AbstractThis proposal brings together a top team with diverse and complementary expertise to develop a novel therapeutic agent based on a newly described serum protein, renalase (RNLS) to treat acute pancreatitis (AP). This protein has a novel protective effect in models of acute tissue injury, including AP. AP affects more than 250,000 people/year in the USA and can cause death in ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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