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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 205201 - 205210 of 207712 results
  1. Modeling Disease in Swine by Transplantation of Gene Targeted Germ Cells

    SBC: Recombinetics, Inc.            Topic: 400

    PROJECT SUMMARY Swine are important in biomedical research for the study of human diseases that are poorly recapitulated by rodent speciesfor the development and testing of preclinical therapeutics in humanized disease models and as potential sources of xenogeneic or allogeneic organs and tissuesHoweverthe creation and propagation of biomedical swine is plagued by inefficiencies related to animal ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Visual Representation Toolkit for Integrated, Goal-Oriented awareness (VIRTIGO)

    SBC: CHARLES RIVER ANALYTICS, INC.            Topic: AF083021

    Advanced workflow and workspace visualization techniques are required to support goal-oriented decision-making in cross-domain system of systems (SoS) engineering applications. To address this need, we propose to design, develop, and evaluate a rich Visu...

    SBIR Phase II 2017 Department of DefenseDefense Advanced Research Projects Agency
  3. Selective Depletion of Insulin-Specific B cells to Prevent Type 1 Diabetes

    SBC: AKSTON BIOSCIENCES CORPORATION            Topic: 200

    PUBLIC DESCRIPTION Akston is developing a subcutaneously administered therapeutic for preventing or delaying the onset of diabetes in pre diabetic patients who are at high riskthose who display autoantibodies for insulinGADIAand ZnTfor developing TypediabetesT DThe therapeutic is designed to delete a subset of B cells that likely play a role in disease development using a patient s own antibody di ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Discovery of PSD95 protein-protein interaction inhibitors as novel non-opioid analgesics

    SBC: ANAGIN            Topic: 104

    Project Summary This application, “Discovery of PSD95 protein-protein interaction inhibitors as novel non-opioid analgesics”, addresses the critical need for more effective medications to treat chronic neuropathic pain. Pain is responsible for more encounters with the health care system than any other single cause, yet treatment options for neuropathic pain have limited efficacy and carry a hi ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Integrin activator-adjuvanted DNA vaccine against Trypanosoma cruzi infection

    SBC: 7 Hills Pharma LLC            Topic: R

    PROJECT SUMMARY/ABSTRACT Trypanosoma cruzi (Tc) is the causative agent of Chagas disease (CD). With rt7 million recorded cases, ~81 million at risk of Tc exposure in Latin America, and large-scale migration from endemic to other countries including the USA where autochthonous transmission of Tc also occurs, CD remains a global health concern. Currently no therapies exist to prophylactically treat ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Autonomous Hull Grooming Vehicle

    SBC: GREENSEA SYSTEMS, INC.            Topic: N18AT020

    The objective of this STTR is to develop a highly autonomous hull grooming system that can be operated easily and cost effectively with minimal supervision. The focus of the Phase 1 effort was to design and characterize the navigation system that can provide the required accurate on-hull navigation. The focus of the Phase 2 Base effort is to demonstrate closed loop autonomous control for relative ...

    STTR Phase II 2019 Department of DefenseNavy
  7. Marine Adaptive Schoolhouse Training with E-learning Repetition Technology (MASTERY)

    SBC: CHARLES RIVER ANALYTICS, INC.            Topic: N192132

    Marines obtain foundational knowledge by using rote learning techniques to master subject matter content, which is typically presented to students through lectures, reading materials, and homework assignments. Learning is most effective when the presentation of content, as well as the testing of acquired knowledge, is tailored to an individual student’s needs and current level of understanding. ...

    SBIR Phase II 2020 Department of DefenseNavy
  8. Repurposing of Pyrvinium Pamoate for Familial Adenomatous Polyposis (FAP)

    SBC: Stemsynergy Therapeutic            Topic: 102

    ABSTRACT Individuals with the rare, inherited disorder Familial Adenomatous Polyposis (FAP) develop thousands of precancerous polyps at an early age and ultimately develop colorectal cancer (CRC). The current standard of care for FAP is colectomy. However, unavoidable side-effects of colectomy are debilitating. Furthermore, colectomy does not prevent subsequent development of extra-colonic intesti ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Improved Influenza Vaccine Efficacy Through Infection Mimicry

    SBC: VAXESS TECHNOLOGIES INC            Topic: NIAID

    Project Summary/Abstract The World Health Organization estimates that influenza viruses cause serious illness in 3 to 5 million people and up to 650,000 deaths globally each year. While seasonal vaccines to prevent influenza infection are available, frequent mutations in the virus require manufacturers to guess which strains will circulate each season and reformulate vaccine on an annual basis. As ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Pirenzepine for CIPN

    SBC: WinSanTor, Inc.            Topic: NCI

    PROJECT SUMMARY Chemotherapy induced peripheral neuropathyCIPNis a debilitating condition that afflictsof cancer patients undergoing chemotherapy and limits the dose and duration of treatmentSymptoms range from sensory loss to painful neuropathy and are accompanied by electrophysiological and structural indices of nerve damageThe American Society of Clinical Oncology currently makes no recommendat ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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