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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 205201 - 205210 of 207712 results
  1. Simple, Home-use, neurostimulAtion tReatment for Parkinson's disease dEmeNtia (SHARPEN)

    SBC: SCION NEUROSTIM, INC            Topic: NINDS

    PROJECT SUMMARY Parkinson’s disease dementia (PDD) is a frequent non-motor symptom in patients with Parkinson’s disease (PD). PDD is associated with cognitive decline that can increase morbidity and mortality and dramatically reduce patient quality of life. Three out of four PD patients will develop PDD, yet the only FDA-approved treatment for PDD is rivastigmine which provides effects that ar ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Intranasal Formulations of Allopregnanolone, a Regenerative Therapeutic for Alzheimer's Disease

    SBC: NEUTHERAPEUTICS, LLC            Topic: NIA

    Project Summary/Abstract Alzheimer’s disease (AD) is a progressive multifactorial disease affecting more than 50 million people worldwide and is the most common dementia of late-life. To date, no interventions have demonstrated substantial therapeutic efficacy to prevent, delay or treat AD. Current thinking in the field embraces the complexity of AD pathophysiology, which has enabled a more dive ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Selective Activators of Nrf2 for Neurodegenerative Disease

    SBC: GROVE BIOPHARMA, INC.            Topic: 105

    Protein-like polymers (PLPs) are next generation biotherapeutics with the potential to improve treatment outcomes for patients suffering from devastating neurodegenerative diseases. We have developed a lead PLP that disrupts the Keap1-Nrf2 intracellular protein-protein interaction (PPI) that restricts the therapeutic activity of Nrf2 (nuclear factor-erythroid factor 2-related factor 2), a validate ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Nitric oxide Releasing Ultra-Slippery Antibacterial Surfaces for Urological Catheter Applications

    SBC: NYTRICX INC            Topic: 400

    Abstract Urinary catheters are one of the most widely used medical devices in a hospital setting and are expected to only increase in growth due to the aging population. Out of all the various biomedical devices that are frequently used in a clinical setting, urinary catheters are associated with the largest portion of medical complications related to infection. Catheter associated urinary tract i ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Population monitoring of stress markers in underserved communities

    SBC: GINER INC            Topic: NHLBI

    PROJECT SUMMARY/ABSTRACT Daily stresses, as well as social, emotional, and financial challenges, can activate physiological stress. Current public health monitoring systems cannot quantify community stress levels for millions of low-resource and underserved communities. By identifying communities experiencing high levels of stress using wastewater- based epidemiology, public health professionals c ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. A Multi-Modal Wearable Sensor for Early Detection of Cognitive Decline and Remote Monitoring of Cognitive-Motor Decline Over Time

    SBC: BIOSENSICS LLC            Topic: NIA

    ABSTRACT Recent demographic changes have led to the emergence of the so-called “dementia epidemic”. Dementia causes great stress to medical, social, and informal care and is currently affecting approximately 55 million persons worldwide. This number is projected to increase to 75.6 million by 2030 and 135.5 million by 2050. Alzheimer’s disease (AD) is a degenerative brain disease and the mos ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Efficient Machine Learning Algorithms for Information Fusion from Radiation Detectors

    SBC: XL SCIENTIFIC LLC            Topic: DTRA212006

    This proposal for Phase II in response to the Defense Threat Reduction Agency (DTRA) topic 212-006 “Algorithm that can locally link radiation detectors (of different resolutions) to enhance identification/ localization capability”. The topic describes the need for an algorithm to support the fusion of multiple and varied detector outputs into actionable information. The specific focus is to id ...

    SBIR Phase II 2023 Department of DefenseDefense Threat Reduction Agency
  8. SBIR Phase I:Multifunctional coatings for building envelopes

    SBC: TECHSTYLE MATERIALS INC            Topic: AM

    This broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will develop coatings for walls and ceilings that have climate-regulating properties, resulting in improved energy efficiency, durability, and comfort for buildings. Buildings account for around 40% of primary energy consumption in the United States, and while increasing insulation and airtig ...

    SBIR Phase I 2023 National Science Foundation
  9. SBIR Phase II:Cellulose Based Material Innovations for an Ocean Compostable, Fish Friendly, Plastic Packaging Replacement Platform Technology

    SBC: PARAMOUNT PLANET PRODUCT LLC            Topic: CT

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is the design of products that will decompose in nature, are paper-stream recyclable, and Ocean Compostable Fish Friendly (OCFF), with a cost similar to plastic packaging.Since 2018, the US typically recycles between 5-8.7% of its plastic. According to Ocean Conservancy, “Every year, 11 mil ...

    SBIR Phase II 2023 National Science Foundation
  10. Precision Glycoengineering of an HCV Envelope-Based Nanoparticle Vaccine

    SBC: NeuImmune, Inc.            Topic: NIAID

    ABSTRACTGlobally, more than 71 million people are infected with Hepatitis C virus (HCV), with 1-2 million new infections occurring each year. This major health concern necessitates the development of an effective vaccine. Since HCV rapidly accumulates mutations, vaccines must elicit the production of broadly neutralizing antibodies (bnAbs) in a reproducible fashion. The viral envelope E1E2 glycopr ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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