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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 205211 - 205220 of 207712 results
  1. High Throughput Testing of Additive Manufacturing

    SBC: MRL MATERIALS RESOURCES LLC            Topic: N18AT028

    Additive manufacturing is a disruptive new manufacturing paradigm that hold tremendous potential for creation of novel designs and introduction of novel new alloy systems. However, much of this potential remains unrealized due to a lack of robust material properties databases. Accurate calibration of materials models and robust part qualification and certification regimes both will require massive ...

    STTR Phase II 2019 Department of DefenseNavy
  2. Perfusion decellularization and recellularization for the creation of a bioengineered transplantable liver

    SBC: Miromatrix Medical Inc.            Topic: 300

    ABSTRACT Liver transplantation currently represents the only treatment for end stage liver disease (ESLD), the 8th most frequent cause of death in the United States (US). Efforts to overcome the chronic shortage of transplantable human livers include attempts at alternative organ procurement and replacement strategies. The most promising approach to date that provides the appropriate matrix compos ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. rhMFG-E8 as an Effective Adjuvant Therapy for Hemorrhagic Shock

    SBC: THERASOURCE, LLC            Topic: NHLBI

    PROJECT DESCRIPTION: This SBIR Phase II project proposes to further develop recombinant human milk fat globule epidermal growth factor-factor 8 (rhMFG-E8) as a novel and effective adjuvant therapy for hemorrhagic shock, which kills 60,000 Americans every year. Hemorrhagic shock results in cell death, and dying cells release damage-associated molecular patterns (DAMPs). DAMPs promote inflammation, ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Supplemental Funding for Grant Named Safety and Pharmacokinetics of JOTROL for Alzheimer's Disease

    SBC: Jupiter Orphan Therapeutics, Inc.            Topic: NIA

    Project Summary Resveratrol has shown potential therapeutic utility in a number of disorders characterized by neuronal degradation, mitochondrial dysfunction, inflammation, and the presence of reactive oxygen species. Resveratrol has shown beneficial outcomes in Alzheimer’s Disease (AD). Resveratrol use is limited by poor bioavailability due to rapid and extensive first pass metabolism. At doses ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Targeting mutant estrogen receptor driven breast cancers

    SBC: Etirarx, LLC            Topic: NCI

    Project Summary/AbstractA majority of Breast cancers (BC) express estrogen receptor alpha (ERα). While endocrine therapies targeting either estrogen production or ERα are effective, acquired resistance is common. Sequencing of metastatic endocrine therapy-resistant (ETR) tumors has shwown that ERα mutations are frequent (30-40%), do not respond to endocrine therapies and are the molecular drive ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Human monoclonal antibodies for prevention of S. aureus infections

    SBC: SORRENTO THERAPEUTICS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Using mouse monoclonal antibodies mAbs raised against the mediators of quorum sensing QS the Auto Inducing Peptides AIPs researchers at The Scripps Research Institute TSRI have demonstrated that S aureus infections can be prevented in animal challenge models This approach known as quorum quenching QQ is unique in at least two significant ways fi ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Design of a Covalent Inhibitor for c-Myc-Dependent Cancers

    SBC: SUVALENT THERAPEUTICS INC.            Topic: 102

    DESCRIPTION provided by applicant The main commercial goal of our company is to develop novel therapeutics to inhibit the human oncogene c Myc C Myc is a major human oncogene that is estimated to contribute to at least of all human cancers most of which are aggressive and respond poorly to current therapies Despite more than years of research on c Myc the development of drugs that i ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. PROGRESS: PRevention of cervical cancer using the Genotyping scREening and Same-day Self-sampling

    SBC: Atila Biosystems, Inc.            Topic: 102

    PROJECT SUMMARY In 2018, the World Health Organization (WHO) called for action towards achieving the global elimination of cervical cancer. Member states ratified a strategy for achieving this goal in August 2020. The WHO plan calls for an aggressive approach of vaccination, screening, and treatment of the human papillomavirus (HPV), the single cause of cervical cancer. In low- and middle-income c ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Service and Software Solution for the Rigorous Design of Animal Studies

    SBC: SERALOGIX, LLC            Topic: NIDA

    The primary goal of this fast track project is to commercialize a cloud based software suite complemented with on call expert services to guide life science researchersthat may have minimal statistical and experimental designEDknowledgeto rigorously planoptimizejustifymanageand report results for complex animal studiesInadequately planned experimentse glack of randomization blinding and diversityl ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Fully-Automated Lesion Characterization in Ultrawide-Field Retinal Images

    SBC: EYENUK, INC.            Topic: N

    AbstractIn this grant application we propose to develop, EyeReadUWF, a fully automated tool for lesion characterization in ultra-widefield scanning laser ophthalmoscopy (UWF SLO) images. In recent times non mydriatic UWF SLO imaging has been shown to be a promising alternative to conventional digital color fundus imaging for grading of diabetic eye diseases, with advantages including 130°-200° f ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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