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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 205251 - 205260 of 207712 results
  1. Increasing platform readiness by integrating Artificial Intelligence & Machine Learning for Extrusion Additive Manufacturing

    SBC: Addiguru, LLC            Topic: AFX23DTCSO1

    Additive manufacturing (AM) has enabled the fabrication of complex designs and highly customized parts previously impossible with traditional manufacturing. The need for specialized tooling is replaced by a heated extruder-nozzle assembly that melts the i

    STTR Phase I 2023 Department of DefenseAir Force
  2. Real-time monitoring of directed energy deposition additive manufacturing process using multiple sensors and machine learning

    SBC: Addiguru, LLC            Topic: X22DOTCSO1

    Additive manufacturing (AM) of components via Directed Energy Deposition (DED) is a complex process involving long deposits of single-walled tracks. DED has been gaining popularity due to its ability to build functionally graded parts as well as repair components. Depending on whether the feedstock material is powder-blown or wire-fed, the source of focused energy can be a laser, electron beam, pl ...

    STTR Phase I 2023 Department of DefenseAir Force
  3. High-throughput Single Cell Co-assay of Histone Modifications and Transcriptome

    SBC: EPIGENOME TECHNOLOGIES, INC.            Topic: 400

    AbstractEpigenome analysis can help dissect the transcriptional regulatory sequences that control spatiotemporal patterns of gene expression during anima development and disease pathogenesis, but a major challenge to epigenome analysis is the heterogeneity of primary tissues. Conventional epigenome assays that take bulk tissues as input only produce population average signals. To address this majo ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. Broadly Accessible Technologies for Single-cell Joint Analysis of Transcriptome and Epigenome

    SBC: EPIGENOME TECHNOLOGIES, INC.            Topic: 101

    AbstractHistone modifications carry rich information of cellular memory and gene regulatory mechanisms. Single cell analysis of histone modification in conjunction with transcriptome could recover this critical layer of cell identity and help to dissect the cellular and molecular composition of complex tissues such as the brain. We recently developed an ultra-high throughput single cell multi-omic ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Single-cell Epigenome Analysis of the Alzheimer's Disease Brain

    SBC: EPIGENOME TECHNOLOGIES, INC.            Topic: NIA

    Title: Single-cell Epigenome Analysis of the Alzheimer’s Disease Brain (PI: Hartl)Alzheimer’s disease (AD) affects more than 6 million American but no cures and few effective treatments are available. Genome-wide association studies (GWAS) have uncovered thousands of segregating mutations that significantly increase AD risk. Most of these variants alter non-protein-coding sequence and lack cle ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. High-throughput Single Cell Co-assay of Histone Modifications andTranscriptome

    SBC: EPIGENOME TECHNOLOGIES, INC.            Topic: 400

    SummaryDisruption of gene regulation is a major causal factor in heritable disease, developmental disorders, and oncogenesis. While chromatin immunoprecipitation followed by sequencing (ChIP-seq) and Tn5- transposase based tagging (CutandTag) enable analysis of transcription factor binding and epigenetic state profiling in bulk tissue samples and tumor biopsies, they produce only population averag ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. SBIR Phase I: Improving food safety using hyper-stable enzyme cleaning products

    SBC: CINDER BIOLOGICAL INC.            Topic: BT

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will be to improve food safety by integrating hyper-stable enzymes into cleaning products. Industrial enzymes are a growing, multi-billion dollar green industry that reduces energy, water, and harsh chemical use while improving process efficiency in many sectors. Despite the broad use and succ ...

    SBIR Phase I 2015 National Science Foundation
  8. SBIR Phase II: Improving food safety using hyper-stable enzyme cleaning products

    SBC: CINDER BIOLOGICAL INC.            Topic: BT

    The broader impact/commercial potential of this Small Business Innovation Research Phase II project will be to improve cleaning in the food processing industry by integrating hyper-stable enzymes into cleaning products. Industrial enzymes are a growing, multi-billion dollar green industry that reduces energy, water, and harsh chemical use while improving process efficiency in many sectors. Despite ...

    SBIR Phase II 2016 National Science Foundation
  9. Novel ultra-stable enzymes and methods for proteomics

    SBC: CINDER BIOLOGICAL INC.            Topic: 400

    PROJECT SUMMARY ABSTRACT ! Proteomics is critical for health research as it enables analysis of proteins involved in a broad range of biological processesAlthough proteomics has laid the foundation for many advances in disease diagnosistreatmentand preventionimprovements in sample preparation and processing of protein and sugar biomolecules have lagged far behind impressive developments in mass sp ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Novel ultra-stable enzymes and methods for proteomics

    SBC: CINDER BIOLOGICAL INC.            Topic: 400

    PROJECT SUMMARY/ABSTRACTThe highly technical and rapidly advancing field of modern proteomics relies heavily on enzyme technologies that were established over one hundred and fifty years ago, namely trypsin. We propose to apply our entirely novel ultra-stable Archaeal proteases to make superior front-end digestion products for proteomics. Our patented technologies allow efficient production of ult ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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