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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 205261 - 205270 of 207712 results
  1. Continuous Interactive Learners for Mission Planning (CILEMP)

    SBC: KNEXUS RESEARCH LLC            Topic: N181079

    A key problem with automated mission planning software is that their underlying domain models may be incomplete, imprecise, inaccurate, or inefficient, and may rapidly become obsolete because of evolving domains. These issues can adversely impact the quality and effectiveness of support offered by automated planning software. In this effort, we will address the planning domain knowledge acquisitio ...

    SBIR Phase II 2019 Department of DefenseNavy
  2. Factor XI inhibitor for thrombosis

    SBC: ARONORA INC            Topic: NHLBI

    Project Summary Although potent antithrombotic agents are availableall of these drugs inadvertently target vital hemostatic molecular mechanismsresulting in dose limiting hemorrhagic toxicity that restrict their useDue to a lack of safe thromboprophylaxisthrombotic blood vessel occlusions continue to be extremely prevalentand result in a wide range of severe disease conditions that remain the lead ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Development of GIFT4: a B cell focused immunotherapy for cancer

    SBC: CELDARA MEDICAL, LLC            Topic: NCI

    Project Summary Our goal is to develop a novel immunotherapy for the treatment of melanomaand potentially a wide array of tumorsAlthough surveillance by the immune system eliminates cancer cells in some instancestumor cells have developed a variety of mechanisms to escape immune recognition often resulting in tumor outgrowthImmune checkpoint inhibitorse gipilimumabnivolumaband pembrolizumaband cel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of SUMO1 small molecule degraders as the first-in-class anticancerdrugs for metastatic colorectal cancer

    SBC: HB THERAPEUTICS INC            Topic: 102

    Project Summary/Abstract Colorectal carcinoma (CRC) is the 4th most diagnosed cancer but the 2nd leading cause of cancer death mainly due to its metastatic disease (mCRC) in the liver and lungs. Currently there is no effective therapy available for patients diagnosed with mCRC. The ultimate goal of this project is to develop small-molecule degraders of small ubiquitin-related modifier 1 (SUMO1) as ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  5. A treatment drug for triple negative breast cancer

    SBC: ProDa BioTech L.L.C.            Topic: 102

    Summary Triple negative breast cancers (TNBC) are devastating diseases with a median survival of less than 1-year for patients with metastatic disease. TNBC patients with tumor of high fibrotic stroma have even worse prognosis. There are no specific targeted therapies available for TNBC, and the only treatment option is broadly cytotoxic chemotherapy drugs, despite less effective and strong unwant ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Lab-on-a-Film Multiplexed Test for Respiratory Mycobacterial Infections

    SBC: AKONNI BIOSYSTEMS INC            Topic: NIAID

    ABSTRACT Nontuberculous mycobacteria lung disease (NTM-LD) is a silent and emerging epidemic in the U.S. and many parts of the world.1-3 The incidence and prevalence of NTM-LD is increasing yearly and now far exceeds that of tuberculosis (TB) caused by Mycobacterium tuberculosis complex in the U.S.4 Two of the greatest known risk factors for NTM-LD are chronic obstructive pulmonary disease (COPD) ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Sonobuoy Launched small UAV system

    SBC: Sensintel Inc.            Topic: N04T004

    The Navy and other government-sponsored agencies use the P-3 aircraft. Due to the diverse missions and limited number of P-3 aircraft, the most economical and expeditious way to enhance operations and assure crew safety would be to incorporate low-cost expendable tactical unmanned air vehicles (UAV's). If UAVs were incorporated into each P-3, a load-out of sonobuoy launched UAV's with interchange ...

    STTR Phase II 2005 Department of DefenseNavy
  8. Next-Generation Adenovirus Vaccine

    SBC: TECHNOVAX INC            Topic: A15051

    One of the most important infectious diseases affecting the health of military recruits is adenovirus, which causes acute outbreaks of respiratory disease in military facilities incapacitating personnel, burdening hospitals, disrupting military operations and increasing medical costs. We propose to continue the development of a new generation of adenovirus vaccines based on adenovirus-like particl ...

    SBIR Phase II 2016 Department of DefenseDefense Health Agency
  9. A Prognostic Blood Test to Monitor Pancreatic Cancer Treatment by MiRNA Profiling

    SBC: VAJRA INSTRUMENTS, INC.            Topic: 102

    Pancreatic ductal adenocarcinomaPDAChas ayear survival rate of less thanThe success in developing therapies for other cancers over the last two decades has not improved the dismal overall survivalOSrate for PDACIt is now becoming increasingly apparent that personalized medicine based on the genetics of a tumor will be essential for developing a treatment strategyThusthere is an urgent need to deve ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Development of chimeric read amplification into a robust method for profiling targets of specific microRNAs and global amplification of all microRNA:mRNA pairings transcriptome-wide

    SBC: Eclipse Bioinnovations, Inc.            Topic: 172

    PROJECT SUMMARYPost-transcriptional regulation by microRNAs is fundamental for cellular homeostasis. MicroRNAs are small non-coding RNAs that fine tune gene expression by base pairing to complementary sequences in target messenger RNA (mRNA) molecules. A single microRNA can have multiple targets allowing for coordinated regulation of mRNA networks. The importance of microRNA regulation is evidence ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
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