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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 207631 - 207640 of 207731 results
  1. Production of antibody therapeutic fragments by reduced genome E. coli in continuous culture

    SBC: SCARAB GENOMICS LLC            Topic: NIAID

    Scarab Genomics’ C-Flow™ technology is a highly efficient continuous culture system that can produce kilograms of protein in a few weeks at a mere 10-liter scale. This project will determine whether C-Flow can be further developed as an efficient system for production of single-chain antibody therapeutics. Antibody fragments, especially single-chain variants, are increasingly important for dia ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  2. SBIR Phase I: Smart Shunt Valve to Treat Hydrocephalus

    SBC: MADISON SCIENTIFIC, INC.            Topic: MD

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop a smart cerebrospinal fluid (CSF) shunt system to improve the treatment of hydrocephalus, called “water on the brain”. Despite being the most common pediatric brain surgery performed worldwide, 40% of CSF shunts fail within the first year and nearly all fail within 10 years, ...

    SBIR Phase I 2021 National Science Foundation
  3. SBIR Phase II:Smart Shunt to Treat Hydrocephalus

    SBC: MADISON SCIENTIFIC, INC.            Topic: MD

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is the development of an advanced electromechanical cerebrospinal fluid (CSF) shunt system for the treatment and monitoring of hydrocephalus. Hydrocephalus is caused by an accumulation of CSF occurs within the brain, often causing an increased pressure inside the skull. Most shunts used to re ...

    SBIR Phase II 2023 National Science Foundation
  4. Development of a Smart Shunt with ICP-feedback for the Treatment of Hydrocephalus

    SBC: MADISON SCIENTIFIC, INC.            Topic: 100

    PROJECT SUMMARY Hydrocephalus is a devastating condition characterized by a buildup of cerebrospinal fluid (CSF) in the brain. The most utilized treatment for hydrocephalus is the CSF shunt in which a catheter diverts excess CSF from the ventricles of the brain through a one-way valve to an area in the body that can reabsorb the fluid (most commonly the peritoneal cavity). Despite technological ad ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Commercialization of a preclinical Magnetic Particle Imaging system with sub-millimeter resolution, nano-molar sensitivity, and integrated CT

    SBC: MAGNETIC INSIGHT, INC            Topic: NIBIB

    DESCRIPTION provided by applicant The two dominant preclinical molecular imaging techniques optical imaging and nuclear imaging have technical limitations that hamper their use in applications requiring high resolution longitudinal tracer imaging with absolute quantitation We are developing a new molecular imaging modality Magnetic Particle Imaging MPI which does not have these limitati ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a Neurovascular Magnetic Particle Imaging system with sub-millimeter resolution and real time speed for non-radiative 3D perfusion angiography

    SBC: MAGNETIC INSIGHT, INC            Topic: NIDA

    DESCRIPTION provided by applicant There is a clinical need for new neurovascular imaging techniques for the diagnosis staging and monitoring of acute stroke and sub acute stenoses arterial venous malformations AVMs and aneurysms among others Together these etiologies frequently manifest in acute stroke and kill over people per year with an estimated cost the US healthcare syste ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Phase II: Commercialization of a preclinical Magnetic Particle Imaging system with sub-millimeter resolution, nano-molar sensitivity, and integrated CT

    SBC: MAGNETIC INSIGHT, INC            Topic: NIBIB

    Abstract The two dominant preclinical molecular imaging techniquesoptical imaging and nuclear imaginghave technical limitations that hamper their use in applications requiring high resolutionlongitudinal tracer imaging with absolute quantitationWe are developing a new molecular imaging modalityMagnetic Particle ImagingMPIwhich does not have these limitations and is capable ofnanomolar sensitivitya ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Phase II: Development of a Neurovascular Magnetic Particle Imaging system with sub-millimeter resolution and real time speed for non-radiative 3D perfusion angiography

    SBC: MAGNETIC INSIGHT, INC            Topic: NIDA

    Abstract Clinicians rely on neuroimaging to visualize life-changing diseases affecting the brain. Current techniques struggle in areas important for neuroimaging such as quantifying cerebrovascular disease, detecting diseases of inflammation, and monitoring newly developed cell-based therapies. This is due to fundamental technical limitations in MRI, CT, and nuclear medicine. For example, CT perfu ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a commercial Magnetic Particle Imaging platform for the detection and quantification of localized inflammation in cancer

    SBC: MAGNETIC INSIGHT, INC            Topic: 102

    Magnetic Insight has developed a Magnetic Particle ImagingMPIproduct based on new pulse sequences and image reconstruction approachesMPI is an emerging tracer imaging technology that is well suited for ultrasensitive imaging of localized inflammationusing safelow frequency magnetic fields to directly detect the spatial distribution of superparamagnetic iron oxideSPIOtracerLocalized inflammation is ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Color MPI as a novel method for in vivo assessment of magnetic nanoparticle dynamics and binding

    SBC: MAGNETIC INSIGHT, INC            Topic: NIBIB

    Summary: Current biomedical imaging methods are indispensable for diagnosing high-mortality diseases like Cancer, Cardiovascular Disease and Stroke. For decades, researchers have attempted to improve the contrast of these imaging methods by injecting two-component ​molecular imaging tracers​: an invisible, physiologically specific targeting agent (peptide, antibody, etc) attached to a visible ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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