You are here
The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
SBC: XFIBRA, LLC Topic: NHLBI
DESCRIPTION provided by applicant Activation of lung myofibroblasts LMF is responsible for the development of lung fibrosis in chronic lung diseases of all causes and remarkably LMF clearance by apoptosis may prevent development of lung fibrosis and lung injury and possibly allow recovery from reversal of lung fibrosis There is full agreement among tissue fibrosis experts that inhibiting o ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: SIGNAL SOLUTIONS, LLC Topic: NHLBI
ABSTRACTSignal Solutions has developed a novelnoninvasive and automated piezoelectric based sleep detection system for high throughput studies of sleep in miceand has recently expanded to rat studies as wellThe respiratory signal detected by the piezo sensor during sleep can be applied to investigate important health conditions including respiratory depression due to disease or drug useand other s ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: BIOLYTIC LAB PERFORMANCE, INC. Topic: 300
Summary RNA synthesis technologies have become critical in basic biomedical research and in development of RNA based sensors diagnostics and therapeutics Currently RNAs are synthesized by either solid phase phosphoramidite chemistry or by transcription in solution with phage encoded RNA polymerases The structural diversity of chemically synthesized RNAs is limited by the availa ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: NEONC TECHNOLOGIES INC Topic: BT
DESCRIPTION provided by applicant Glioblastoma multiforme GBM the most common and malignant of all gliomas has a median survival time of months Standard of care chemotherapy using temozolomide TMZ is effective initially but the GBM inevitably recurs and these recurrent tumors are resistant to TMZ There are currently no effective treatment options for patients with TMZ resistant ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: CAPRICOR, INC. Topic: NHLBI
DESCRIPTION provided by applicant One of the most complex forms of congenital heart disease hypoplastic left heart syndrome HLHS affects an average of in every newborns with a mortality rate of up to percent during the first year of life The overall goal f our research is to develop safe and effective ways to improve short term and long term survival rates in babies born with HL ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
The Microscopic Imaging of Epigenetic Landscape- NeuroDevelopment (MIEL-ND) assay: a high throughput platform to screen compounds for neurodevelopmental effectsSBC: VALA SCIENCES, INC. Topic: 101
Neurodevelopmental diseasesNDDsAutism Spectrum DisorderASDIntellectual DisabilitiesBipolar disordersand Schizophreniaetcare prevalent and due to errors in neurodifferentiation and neurocircuitryWhile NDDsin many casesare due to inherited mutationsevidence is mounting that prenatal exposure to environmental toxicants also cause NDDs via disruption of epigeneticse gmodifications of histoneshistone t ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: NGOGGLE INC Topic: N
PROJECT SUMMARY Assessment of loss of visual function outside the foveal area is an essential component of the management of numerous conditionsincluding glaucomaretinal and neurological disordersDespite the significant progress achieved with the development of standard automated perimetrySAPmany decades agoassessment of visual field loss with SAP still has significant drawbacksSAP testing is limi ...STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: NEUROFIELDZ INC. Topic: NEI
Amblyopia is the most common cause of monocular visual impairment in children and young adultsaffectingpeopleAmblyopia is generally treated with patching or atropine therapyhowever these treatments are not effective in adults and up to half of juvenile casesoften because of poor complianceand cannot easily be personalized during therapyThese factors have led to recent interest in customized game b ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: TRELLIS BIOSCIENCE, INC. Topic: NIAID
DESCRIPTION provided by applicant About of serious bacterial infections are biofilm mediated Not only do biofilms provide an anchor and physical protection for bacterial cells but the physiology and genetic programming of bacteria also shifts between the planktonic free floating and sessile stationary states Most notably antibiotic sensitivity differs betwen the two states with ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: SYMBIOTIX BIOTHERAPIES, INC. Topic: 300
PROJECT SUMMARY ABSTRACT Interactions between the gut microbiome and the immune system have been linked to inflammatory bowel disease IBD IBD is a chronic and progressive gastrointestinal disease characterized by uncontrolled activation of the intestinal immune system resulting in severe medical complications affecting over million patients in the United States It is a disease of high u ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health