Award Data

Antimicrobial resistance is a major public health problem worldwideNeisseria gonorrhoeaeNgthe causative agent of the sexually transmitted infection gonorrheahas become multidrug resistant and has achievedsuperbugstatusIn additionbetweenandof women successfully treated for gonorrhea are re infected within three monthsNovel therapeutics against Ng are urgently neededComplementCis a key arm of innate ...

PROJECT SUMMARY MyoGene Bio is a startup dedicated to developing cutting edge genetic therapies for muscle diseasesIn this proposalthe company will advance development of our potential therapeuticSPY DYSa CRISPR Casgene editing platform for Duchenne muscular dystrophyDMDin conjunction with research partners at UCLADuchenne is a devastating muscle wasting disorder with no cure that is caused by out ...

ABSTRACTMicroarrays are an important research tool (genomics and proteomics) and clinical tool (biomarker discovery and diagnosis). Current microarray processing methods are limited by slow assay kinetics, are not amenable to automation, and require high volume of expensive reagents/buffers. Miniaturization of these technologies has been explored to improve throughput. The demand for microarrays c ...

Abstract We propose an ultrasensitive rapid diagnostic testRDTto detect exposure to pulmonary flukes of the genus ParagonimusParagonimiasis affects an estimatedmi l l ion people and remains amongst the most neglected of all neglected tropical diseasesNTDsThis trematode is acquired upon ingestion of raw or undercooked freshwater crustaceans and migrates to the lungs where it forms cystsTreatment is ...

Activation of liver myofibroblastsLMFof different origins is responsible for the development of liver fibrosis in chronic liver diseases of all causes and remarkablyLMF clearance by apoptosis may prevent development of liver fibrosis and liver injuryand possibly allow recovery from reversal of liver fibrosisInhibiting o reversing myofibroblast activationthe therapeutic cellular targetis critical f ...

PROJECT SUMMARY ABSTRACT This proposed SBIR study is for the advancement to market of a medical system that automatically and quickly measures and quantifies EEG signals to correlate with clinical staging and cognitive impairment associated with Alzheimer s DiseaseADand mild cognitive impairmentMCIThe envisioned systemdesigned to be used in emergentinpatientambulatory and research settingswill pro ...

Abstract The objective of this NIH Phase II SBIR proposal is to demonstrate the commercial feasibility of IsoTag™, a novel cost-effective method to purify monoclonal antibodies (mAbs) that eliminates the need for Protein A (PrA) chromatography. This objective will be achieved by using a recombinant fusion comprised of a stimulus responsive elastin-like polypeptide (ELP) that can undergo a revers ...

Summary In this Phase I program we will establish the feasibility of a novel filter paper whole blood sample based targeted sequencing assay based on the TempO Seqplatform to measure DNA and RNA profiles as the basis for the development of a minimally invasive prognostic diagnostic assay of Alzheimer s DiseaseADWe will use our already functional whole transcriptome targeted gene expression assay t ...

ABSTRACT Venous access is the most commonly performed invasive medical procedure with overmillion peripherally inserted venous cathetersPIVCused annually in the US andbillion globallyHoweverthe rate of failure prior to completion of therapy remains unacceptably high in pediatric patientswith a reportedciting complications and removal withinhours of placementThe high rate of PIVC failure in pediatr ...

ABSTRACT This Administrative Supplement is for Aim 2-1: Synthesize sufficient compound quantities to support xenograft studies. Our aims remain within the same scope of our original proposal. Unexpectedly, we found that adding a chiral center confers a great profile on our leads versus non chiral compounds. We showed that chiral leads are selective for SGK1 versus AKT1 (20-fold), active in cells ( ...