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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Developing novel combination therapies for HSV genital infection.

    SBC: CASTERBRIDGE PHARMACEUTICALS INC            Topic: NIAID

    Herpes simplex virusesandHSVHSVcause a wide range of serious diseasesincluding oral genital lesionscorneal blindness and eczema herpeticumHSVand HSVare both transmitted sexually and can infect babies during birthTherapy for HSV relies primarily on nucleoside analogs such as acyclovirACVwhich are insufficiently effectiveand resistant viruses are becoming common among immunosuppressed personsTherefo ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Targeting the sphingolipid pathway for the R&D of new antifungals

    SBC: MICRORID TECHNOLOGIES INC            Topic: NIAID

    ABSTRACT The goal of this project is to discover and develop a new therapeutic smore potent than current antifungals for the treatment of invasive fungal infectionsAmong invasive fungal infectionscryptococcosiscandidiasisand aspergillosis are the most life threateningThe incidence of these infections has risen more thanfold over the lastyearswith a mortality rate ofyearWe recently discovered a fun ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Small Molecule Anti-Inflammatories for Ocular Graft Versus Host Disease

    SBC: Eyedesis Biosciences, LLC            Topic: NEI

    PROJECT SUMMARYABSTRACT Ocular graft versus host diseaseOGVHDis a severe ocular surface inflammatory diseaseOSIDoccurring in patients undergoing allogenic hematopoietic stem cell transplantationHSCTOGVHD is characterized by dry eyemeibomian gland dysfunctionconjunctival scarringlid margin scarringkeratopathyand corneal ulcerationcausing significant ocular morbidity and vision loss for affected pat ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Theranostic Virtual Reality Headset for Amblyopia

    SBC: NEUROFIELDZ INC.            Topic: NEI

    Amblyopia is the most common cause of monocular visual impairment in children and young adultsaffectingpeopleAmblyopia is generally treated with patching or atropine therapyhowever these treatments are not effective in adults and up to half of juvenile casesoften because of poor complianceand cannot easily be personalized during therapyThese factors have led to recent interest in customized game b ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Nanofiber Expanded CD34+ Stem Cells for Osteoporosis Therapy

    SBC: HNB Therapeutics LLC            Topic: NIA

    Summary Glucocorticoid induced osteoporosis is the most common cause of secondary osteoporosisand the primary cause before ageIt affects overof the general populationwhereinare womenIn postmenopausal women and men agedand overtreatment would be recommended in at least half based on theAmerican College of Rheumatology guidelinesAdult stem cells are a promising class of regenerative cellssome lineag ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Brillouin optical eye scanner prototypes for commercialization

    SBC: INTELON OPTICS, INC.            Topic: N

    ABSTRACT The overall goal of this STTR project is to commercialize a novel optical eye scanner device capable of measuring the biomechanical properties of tissues via Brillouin light scatteringThe Brillouin technology invented in the co PI s lab has shown broad potential for improving the diagnosis and treatment of vision disordersClinical data obtained with current laboratory systems revealed cor ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting glioblastoma stem-like cells with custom-designed viral vectors

    SBC: Lacerta Therapeutics, Inc.            Topic: 102

    Abstract GlioblastomaGBMis the most lethal form of adult brain cancers with a median survival of andltmonths despite aggressive standard chemoradiationGBM are formed by GBM stem like cellsGSCsa major contributor to tumor recurrence and a natural focus for therapeutic developmentThere are two main reasons responsible for treatment failurehigh intraand inter tumor cellular and molecular heterogeneit ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. A 3D Printed Resorbable Antimicrobial Envelope to Prevent Infection of Implanted Cardiac Devices

    SBC: N8 MEDICAL INC            Topic: NHLBI

    ABSTRACT Infection is a serious and potentially fatal complication of surgery to deliver cardiovascular implantable electronic devicesCIEDsi epacemakers and implantable cardioverter defibrillatorsUntreated device related infection is associated with mortality rates as high asCurrentlyonly one antibiotic impregnated mesh has been FDA approved for placement in surgical incisions to reduce infections ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. PAR2 Pepducins as a Novel Treatment of Idiopathic Pulmonary Fibrosis

    SBC: OASIS PHARMACEUTICALS, LLC            Topic: NHLBI

    Idiopathic pulmonary fibrosisIPFthe most common of the interstitial lung diseasesoccurs in aboutpeoplewithnew cases diagnosed annually in the USThe typical clinical course is a progressive fibrotic disease characterized by scarring and `honeycombingandaposof the lungs causing an irreversible loss of the tissueandapos s ability to transport oxygenCo morbid pulmonary hypertension is commonly seen in ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Underwater Blast Injury Monitoring

    SBC: TRITON SYSTEMS, INC.            Topic: DHA17C002

    Triton Systems, Inc. proposes to develop a piezo-textile that can capture underwater explosion pressure wave patterns to ultimately establish and monitor for injury risk severity. We propose to use a state-of-the-art piezo-textile to which we will apply our own proprietary treatments.We will assess our textiles pressure detection performance and durability against a non-textile piezoelectric array ...

    STTR Phase I 2018 Department of DefenseDefense Health Agency
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