Award Data

SBIR 2020: 6823823214: The development of FastMyco™: A novel isothermal colorimetric assay for the rapid detection of mycoplasma contamination. The development of FastMyco™: A novel isothermal colorimetric assay for the rapid detectionof mycoplasma contamination. Project Summary/ Abstract(Word Count: 350) Mycoplasma (myco) contamination of mammalian cell lines are recognized as a major contrib ...

PROJECT SUMMARY (ABSTRACT) Spinal cord injury (SCI) affects an estimated 285,000 Americans. Damage to nerves in the spinal cord can result in a loss of voluntary control over bladder and bowel function that often produces both incontinence and retention of urine and stools in the same patient. The standard of care for urine retention is bladder catheterization to void urine, which may produce urin ...

We propose to develop a simple, non-invasive treatment for obstructive sleep apnea (OSA) that uses head and neck exercises to increase oral, pharyngeal, and cervical muscle strength. OSA is a disorder of repeated upper airway obstruction during sleep that is associated with substantial cardiovascular morbidity and mortality, endocrine disturbances, daytime somnolence, decreased quality of life, an ...

Abstract: DFMO Therapy for Autosomal Dominant Polycystic Kidney Disease (ADPKD)ADPKD is an important human disease affecting 600,000 Americans of all racial and ethnic backgrounds and accounts for about 10% of all end-stage renal disease (ESRD). We discovered that immune- based metabolic reprogramming of arginine metabolism in brain disease is based upon an M2-immune signature that is defined, in ...

Project Summary/Abstract After decades of advances in medical imaging, X-ray based imaging modalities are still the backbone of modern general and targeted diagnostic and therapeutic imaging. With the advent of flat panel detector technology, flat panel X-ray imagers (FPXIs) are now widely used in digital radiography, fluoroscopy, digital tomosynthesis, image-guided radiation therapy, and cone bea ...

Project Summary/Abstract Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Due to the complex nature of PCOS, diagnosis is often delayed and options for treatment and self-management are limited. With recent developments in high-throughput, next- generation and metabolomics technologies, there is now a unique opportunity to utilize a cost- effec ...

Idiopathic pulmonary fibrosis (IPF) is one of the most fatal lung diseases with high mortality and very limited treatment options. Increased production of collagen is found in IPF patients’ lung. Unfortunately current FDA- approved treatments do not stop disease progression. In vitro and in vivo proof-of-concept studies have been completed by our company and demonstrated that inhibiting peptidyl ...

Project Summary The global prevalence of chronic kidney disease (CKD) is estimated to be greater than 10%, affecting approximately 500 million people around the world, and due to the global type II diabetes epidemic, incidence is expected to rise. CKD-specific treatments do not currently exist. Clinical management focuses primarily on controlling blood pressure using renin–angiotensin system (RA ...

The goal of this proposal is to develop a fermentation system to produce a variety of rare and deoxysugars using promiscuous DHAP-dependent aldolases. Carbon-carbon bond forming aldolase reactions are of great relevance to the preparation of fine chemicals, intermediates and bioactive chemicals. The aldolase enzymes responsible for this kind of C-C bond formation catalyze an asymmetric aldol conde ...

Project Summary/Abstract The goal of the proposed SBIR project is to develop, implement, and demonstrate the feasibility of a Digital Pressure Injury Monitoring (DPIM) system to reduce the risk of Hospital-Acquired Pressure Injuries (HAPIs). HAPIs are a common, costly, and serious problem for public health. Ocuvera’s DPIM system will use data from three-dimensional video processing and custom al ...