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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 24881 - 24890 of 28976 results
  1. Telerehabilitation Combining Virtual Reality Adaptable Games and Drug Therapy for Early Alzheimer's Disease

    SBC: Bright Cloud International Corp            Topic: NIA

    PROJECT SUMMARY Objectives: The first objective is to develop a computer-based cognitive training system for individuals in the early stages of Alzheimer’s Disease. The product, a home-based custom Virtual Reality (VR) system will be developed, targeting cognitive domains (processing speed, executive functions, attention, language, memory) as well as depression. The system will incorporate a nov ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Lead optimization and development of novel targeted small molecule therapeutics for Alzheimers disease

    SBC: Epigen Biosciences, Inc.            Topic: NIA

    Alzheimerandapos;s disease (AD) is a devastating disease, with an insidious onset and relentless progress. It produces distressing changes in memory, thought, perception, and often behavior. These changes increasingly impact the patientandapos;s daily life, reducing functional independence, until ultimately, the patients are entirely dependent on others. AD is a progressive disease, where the neur ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A phenotypic screen for compounds that differentially affect excitatory and inhibitory neuronal signaling

    SBC: Q-State Biosciences, Inc.            Topic: 101

    Project SummaryMaintaining the appropriate balance of excitationEvsinhibitionIin the nervous system is essential for normal brain functionas disruptions in E I balance are associated with disorders such as autism spectrum disorderASDschizophreniaand seizuresDevelopment of therapeutics for ASD and schizophrenia has lagged due to their multifactorial etiology and challenges in modeling relevant biol ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Denaturation-Free DNA Target Enrichment and Direct Sequencing of Large Chromosomal Segments

    SBC: GENERATION BIOTECH, LLC            Topic: 172

    SummaryThird generationlong read sequencing technologies are increasingly sought after for the analysis of difficult genomic regionssuch as the major histocompatibility complexMHCthe human leukocyte antigenHLAloci and genomes of cancerspathogens and viral insertionsas well as plant and animal genomesSuch methods provide researchers with more contextual informationenabling analysis of highly comple ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Improved Ratiometric Voltage-Sensitive Dyes for In-Vitro and In-Vivo Imaging of Brain Electrical Signaling

    SBC: POTENTIOMETRIC PROBES LLC            Topic: 101

    Project Summary/Abstract Potentiometric Probes Voltage-sensitive dyes can be applied to brain cells and tissue to study the electrical signals used by the brain to function. The fluorescent dye molecules light up under a microscope and convert tiny electrical signals to measurable changes in light intensity. Virtually all neurological disorders involve changes in the brain’s normal electrical ac ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of an Intratracheal Device to Automate Airway Drug Delivery in Animal Models

    SBC: Microtek            Topic: 100

    Project SummaryAbstractThe rate of FDA approval for respiratory drugs is onlymuch lower than drugs developed for other key therapeutic areasThe lower success rate for respiratory drugs can be attributed to the lack of innovation for developing inhaled therapeuticsespecially tools needed for early drug development phasesThe early assessment of a drug s metabolismpharmacokineticsand toxicologyDMPK t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Anti-sense oligonucleotide platform for rare genetic diseases of the nervous system

    SBC: Q-State Biosciences, Inc.            Topic: 101

    Project SummaryAntisense oligonucleotide platform for rare genetic diseases of the nervous system Rare diseases affect nearly one in ten people in the United StatesApproximately two million of those individuals suffer from rare diseases of the nervous system such as ALSFragile X SyndromeRett Syndromeand severe epileptic encephalopathiesOrphan disease variants are often not of interest to large pha ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Infection Resistant Hemodialysis Access Graft

    SBC: HEALIONICS CORPORATION            Topic: 400

    Infection Resistant Hemodialysis Access Graft vPROJECT SUMMARY ObjectiveThe objective of this Phase I SBIR project is to validate a new synthetic vascular graft construction designed toreduce infection failures of arteriovenousAVgraftsBuilding upon a previously demonstrated approach for preventingvenous end stenosisvia suppression of perigraft fibrotic encapsulationthe new design includes features ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A novel biodegradable nerve conduit drug delivery device for peripheral nerverepair

    SBC: Microsurgical Innovations Inc            Topic: 999

    Project Summary Nerve injury can occur due to traumachronic compression or disease processes such as diabetes or tumors and have a tremendous socioeconomic impact from loss of work and healthcare costsThere is still a clinical need to improve recovery from nerve injuriesand a new nerve conduit drug delivery device that addresses this clinical need is the focus of the present proposalOur group has ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Immune Mediator Based Blood Tests that Inform Concurrent and Future Clinical Disease Activity in Systemic Lupus Erythematosus (SLE)

    SBC: PROGENTEC DIAGNOSTICS INC            Topic: NIAID

    PROJECT SUMMARY ABSTRACTSystemic lupus erythematosusSLEis a multifaceted autoimmune disease characterized by immune dysregulationdisabling symptoms and progressive organ damageRecognition and early treatment to prevent tissue and organ damage is challengingas signs and symptoms of high disease activity and clinical disease flare are captured after their occurrenceDespite clinical instruments of di ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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