Award Data

Project Summary/Abstract The fight against antibiotic resistance, one of the most pressing healthcare concerns worldwide, will require an all-of-the-above approach, with one important element being the development of innovative rapid diagnostics. PhAST Corp. has developed a new antibiotic susceptibility testing (AST) approach that has promise to significantly accelerate AST, from tens of hours to ...

Lassa virusLASVthe causative agent of Lassa hemorrhagic feverLHFcausesmillion infections anddeaths each yearand further threatens global health security as a potential cause of epidemics and pandemicsRapid and accurate diagnosis is critical to global health effortswith a clear effect on LASV treatmentvaccine developmentand outbreak containmentAs observed in theNigeria outbreakburdensome and time c ...

Consumer safety concerns are mounting as engineered nanoparticlesENPsare increasingly being incorporated into consumable productssuch as fooddrugsand personal care productsWhile toxicological effects of inhaled and skin contacting ENPs have been evaluatedvery little is known about the short term and long term effects of ingested ENPsTo evaluate the safety and possible toxic effects of ENPs on the ...

PROJECT SUMMARY Central Nervous System disorders have proven to be among the most difficult of diseases to treat and have placed an enormous burden on society. A major contributing factor to this situation is that currently we often cannot distinguish between normal and pathological states since we do not possess even a basic andapos;ground truthandapos; map of how neurons and other cells are arra ...

Esophageal Atresia (EA) is a congenital birth defect characterized by a discontinuity of the esophagus. Each year several thousand children are born within the EA spectrum. Babies born with EA have trouble feeding, and require a procedure to correct the abnormality. The best treatment for EA is surgery reconnecting the two ends of the esophagus to each other. In some children, however, the gap bet ...

Project Summary Abstract Our NIH SBIR project is to validate a Clinical Guidance System to assist practitioners in underserved and health disparity environmentsWe will apply our Clinical Guidance System for nurse educationThe Clinical Guidance System is being trained across diverse medical disciplines across various healthcare dataThis will then guide practitioners in diagnosis and treatment knowl ...

ABSTRACT Gonorrhea is a genital tract infection caused by Neisseria gonorrhoeaeIt does not induce a state of specific protective immunity and can be acquired repeatedlyDespite public health measuresgonorrhea persists at an unacceptably high frequencyand there is no vaccine against itThe continued emergence of antibiotic resistance threatens to render gonorrhea untreatableOur findings have revealed ...

Major depressive disorder is a debilitating mood disorder that affects ~7% of US adults in their lifetime, costing the U.S. economy more than $200 billion a year. Drugs that increase monoaminergic signaling are the mainstay of depression therapy, but have a delayed onset of action and are only effective in about 50% of affected patients. Aberrant brain-derived neurotrophic factor (BDNF) signaling ...

Under microscopeit is easy to identify cells of specific morphological phenotypes or interacting with other cell typesBut it is not trivial to pick the very cell out without submicron precision mechanical instrumentmicro pipetting or laser micro dissectionTo facilitate image based single cell isolationwe seek to develop an LCD aided selection under microscopeLASUMtechnology that will allow us to p ...

ABSTRACTApproximatelypeople in the United States have been diagnosed with a primary brain tumorOf thesemalignant gliomasMGsaccount for approximatelyof all intracranial tumorswith an overall patient survival rate of onlyMore than any other cancerbrain cancer has lasting physicalcognitiveand psychological impacts on a patient s lifeand the highest per patient initial cost of careSurgical resection r ...