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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Portable Device for Accurate Mouse Tail Vein Injection

    SBC: Technology Commercialization Partners LLC            Topic: OD

    PROJECT SUMMARYABSTRACT To datethe standard method to access a mouse tail vein is manual injectionbut its yield rate is poor in generalThis leads to multiple needle insertions associated with tissue damage and painBesidesfailure in tail vein injection leads to data lossand thereby more animals will be required to compensate itFinallythe dose variation induced by unreliable injection increases erro ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. DR?1-MOG as a Next-Generation Immunotherapy for Methamphetamine Use Disorder

    SBC: VIROGENOMICS BIODEVELOPMENT INC            Topic: R41

    Methamphetamine use disorder is associated with damage to regions of the brain that control cognitive and psychiatric functionOne third to one half of adults with methamphetamine use disorder experience cognitive impairments and other psychiatric symptoms that significantly impact treatment outcomesincreased relapse and lower treatment retention ratesMounting evidence demonstrates how immune facto ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Gene Therapy to Prevent Esophageal Cancer Associated with Aldehyde Dehydrogenase Deficiency

    SBC: LEXEO Therapeutics LLC            Topic: 400

    AbstractLEXEO TherapeuticsLLCis an early stage biotechnology company focused on using in vivo gene therapy technologies to treat disorders of unmet medical needLEXEO is developing an in vivo gene therapy strategy as a preventative therapy to protect individuals with aldehyde dehydrogenaseALDHdeficiency from the high risk for esophageal cancerAs the next step in the development paththe goal of this ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Novel Flexible Access Port for Extra-Cardiac Beating Heart Repair

    SBC: Nido Surgical, Inc            Topic: NHLBI

    ABSTRACT The overall goal of this Phase I STTR project is to develop an epicardial endoscopic instrumentCardioPort ECfor safe and precise dissection and stabilization of the heart surface to enable epicardial ablation of ventricular arrhythmiasEffective treatment of ventricular tachycardiaa lifethreatening arrhythmiain patients with ischemic heart disease often requires both endocardial and epicar ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Regenerative rotator cuff repair in a clinically relevant chronic disease model

    SBC: Cytex Therapeutics, Inc.            Topic: NIAMS

    ABSTRACT Rotator cuff repairRCRis a common first line surgical solution to symptomatic rotator cuff injurywith overRCRs performed annuallyand growing at a rate ofUnfortunatelyof the cases are complicated by failure and re tear of the repaired tendonwhich commonly results in a significant reduction in activities of daily livingworkand or sports and recreation for the patient due to pain and restric ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Establishing a mechanistic foundation for drug discovery: The ABCA4 transporter in Stargardt Disease and other retinopathies

    SBC: Rectify Pharmaceuticals LLC            Topic: NEI

    ABCAis an ABC transporter found in retinal photoreceptor cellsMutations in ABCAhave been implicated in retinopathies such as autosomal recessive Stargardt macular degenerationcone rod dystrophyretinitis pigmentosa and age related macular degenerationABCAfunctions as an importerandflippasemoving N retinylidene phosphatidylethanolamineN retinylidene PEfrom the lumen to the cytoplasmic leaflet of dis ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Wearable Fluorescence Imaging Device for Intraoperative Identification of Brain Tumors

    SBC: BIOPTICS TECHNOLOGY LLC            Topic: 102

    ABSTRACTApproximatelypeople in the United States have been diagnosed with a primary brain tumorOf thesemalignant gliomasMGsaccount for approximatelyof all intracranial tumorswith an overall patient survival rate of onlyMore than any other cancerbrain cancer has lasting physicalcognitiveand psychological impacts on a patient s lifeand the highest per patient initial cost of careSurgical resection r ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A portable multi-parametric optical spectroscopy device for key vascular and metabolic endpoints monitoring in small animals

    SBC: Zenalux Biomedical, Inc.            Topic: OD

    Altered vascularity and deregulated metabolism are two important cancer hallmarksInterest in therapeutically exploiting these functional endpoints continues to growsince metabolism and vasculature significantly impact a tumor s fateThere is growing demand for systems level technologies that measure tumor metabolism within an intact microenvironment to inform strategies to prevent resistancerecurre ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Innovative 3D Printed Intravaginal Ring AnelleO-PRO, the first Single Administration of Progesterone for Infertility

    SBC: Anelleo, Inc.            Topic: NICHD

    Infertility is a global health problemand in the USmillion women are treated for infertility every yearThere is a strong need to promote patient friendly methods for progesterone supplementation in assisted reproductive technologyARTIntravaginal rings are well tolerated by womenare efficacious for contraception and hormone replacement therapyhave high patient complianceand are now in development f ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A universal mechanobiology tool for drug discovery in lung diseases

    SBC: Mechanobiologix L.L.C.            Topic: NHLBI

    Abstract Despite significant effortsno cure exists for the major respiratory diseases such as asthmaemphysema and pulmonary fibrosis due to a lack of proper preclinical methodsDrug development is often carried out in cultured cellsWhile amenable to imaging and manipulationthis approach lacks the native tissue environment and neglects the effects of mechanical forces due to breathing which influenc ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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