Award Data

The macrolides are microbial natural products with many uses in clinical and veterinary medicine. Erythromycin is the best studied example of a macrolide antibiotic; rapamycin and FK506 are promising new immunosuppressant macrolides. The price and availability of macrolides depend on their production efficiency, and therefore, on the genetics of the producing strain. Recently, university studies h ...

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Our long-term objective is the approval of a new drug application (NDA) for civamide as a topical therpes simplex virus (HSV) infections. In the United States, genital HSV affects more than 25 millioHSV effects up to 100 million individuals. The enormous number of affected individuals makes this ancommercial opportunity. In previous preclinical studies using the guinea pig model of HSV-type II inr ...

This proposal is directed towards the design, creation, and optimization of a peptide synthesis instrument capable of synthesizing over 100 peptides at a time by using the broadly accepted FMOC or t-BOC chemistries on traditional resin supports. Parallel segmented synthesis will operate at cycle times of 30 minutes for simultaneous addition of 16 amino acids and up to 16 synthesis stacks, and both ...

Orthotopic liver transplantation is an effective and increasingly popular therapy for a variety of liver diseases, but there is as yet no method for temporarily sustaining a patient awaiting transplant who enters into hepatic failure. C3A is a human liver cell line derived from an hepatoblastoma that retains most of the characteristics of the human hepatocyte. We have cultured these cells in hollo ...

We will test, in rabbits, implants that slowly release antiproliferative drugs that could improve tocular surgery. In one case the objective is to inhibit the growth of residual lens epithelium aftersurgery, and in another to prevent the sealing up of the drainage pathway by fibroblast activity aftoperation. The primary drug to be tested is Daunomycin, and its carrier will be nylon which has beend ...

Oral pharmaceuticals currently are not delivered in gel form because doses cannot be accurately meapouring a gel into a calibrated cup or a spoon. However, an aerosol dispenser recently invented by tfor this project, Dr. James Martin, appears to offer potential as a means for orally administering iof gel medication. J. H. Martin, Inc., the applicant organization, owns the patent rights to this dit ...

The Digital Diary is intended to give clinicians administering ambulatory blood pressure or ecg recresearchers evaluating pharmaceuticals and biologicals, a device that will improve subject compliancimprove quality of data collected, and reduce time required to collect and analyze data. The Digitalmicrocomputer controlled, having voice conversion/compression circuitry, and real-time clock/calendav ...

A number of studies have suggested that noninvasive surgery using high intensity ultrasound ablatiofeasible, and offers significant advantages over conventional surgical techniques for many applicatiultrasound transducer is used to insonate a small tissue target or targets deep within the body caustargeted tissue. In the past, ultrasound delivery systems for high intensity focal surgical applicate ...

We will develop an optimized transformation system with Agrobacterium to provide marker-free transgGenetically engineered plants that lack antibiotic or herbicide resistance genes are free of concernenvironmental effects that might arise from the use of these marker genes. Moreover, with each new tselectable marker must be used. This proposal will allow development of transgenic plants lacking mav ...