Award Data

It is estimated that 220,000 people suffer cardiac arrest each year in the US, of whom only 10,000 survive to hospital discharge. The number of survivors could increase 10-fold if paramedical attention and/or defibrillation were available within a few min

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project aims to develop a novel dry powder inhalation system, Aktiv-NebTM, for delivering antiviral drug (siRNAs) powders, to the respiratory systems of infants and young children as an intervention strategy for respiratory infection RSV. RSV-specific siRNAs developed by Alnylam Pharmaceuticals, have been demonst ...

DESCRIPTION (provided by applicant): Aktiv-Dry LLC, in collaboration with Nabi Biopharmaceuticals, proposes to develop and evaluate in animal models the needle-free respiratory delivery of fine dry powder nicotine vaccine. While syringe and needle have bee n a common vaccine administration mechanism, international authorities recognize a growing requirement for alternative formulations and deliver ...

ANT has recently developed a similar recovery system for our own autonomous vehicle. ANT’s current system lifts a vehicle of lighter negative buoyancy (~64lbs rather than 200 lbs). The system is also designed to operate at less maximum depth (200 m, rather than 900 ft). These changes will necessitate the use of a larger volume lift bag and a modified compressed gas canister for the MK54 torpe ...

This Small Business Innovation Research (SBIR) Phase I project aims to provide an information technology based software system that will support productivity for Tribal grantees using a culturally comprehensible, project management tool. The intellectual merit of this project is an enabling technology that integrates Native ways of knowing and learning with Native ways of doing technology. Researc ...

Novel Li ion batteries with higher energy and power densities, as well as improved stability, are required for use in hybrid/electric vehicles,HEVs, and plug in HEVs, as replacements for the heavier, larger nickel metal hydride batteries. However, Li ion batteries suffer from several problems including performance degradation and safety issues. Promising nanomaterial anodes are being developed t ...

The Small Business Technology Transfer Research (STTR) Phase I project will develop diffusion barriers for organic electronic devices. Innovative new films formed from inorganic/polymer multilayers are excellent flexible gas diffusion barriers to protect organic electronic devices. Current coating technologies can not meet the requirements for low water and oxygen permeability for flexible organic ...

This Small Business Innovation Research (SBIR) Phase I research project aims to develop a novel detection system based on surface plasmon resonance (SPR) and common path interferometric detection (CPI), to detect binding events of biological relevance. The investigators will use self assembled monolayer (SAM) chemistry, or a three dimensional binding surface comprised of polymers to bind the anti ...

This SBIR Phase II project aims to develop a commercial grade optical probe and system for FDA clinical trials and subsequent commercialization of a population-wide colon cancer screening test. An interdisciplinary research team of engineers, biologists, and clinicians has developed low-coherence enhanced backscattering (LEBS), an optical technique which enables sensing tissue microarchitectural c ...

DESCRIPTION (provided by applicant): The goal of this small business technology transfer application is to validate and commercialize an improved means of polyp detection during colonoscopy: spectroscopic microvascular blood assessment from the endoscopically normal mucosa. Missed lesions on colonoscopy are a major problem (conservatively estimated to be ~25% of adenomas and ~4-5% of carcinomas) w ...