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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel adjuvant therapy for triple negative breast cancer

    SBC: JYANT Technologies, Inc.            Topic: 102

    DESCRIPTION provided by applicant Triple negative breast cancer TNBC is very difficult to treat and has no specific targeted therapies Chemotherapies used to treat this disease have many undesirable side effects and patients eventually relapse as a result of chemoresistance Obesity is pandemic in the US and many TNBC suffer from this as well Obesity is accompanied by high levels of leptin ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. A Dietary Supplement As Adjunct Therapy In Castration-Resistant Prostate Cancer

    SBC: MetCure Therapeutics LLC            Topic: 102

    DESCRIPTION provided by applicant Castration Resistant Prostate Cancer Castration resistant prostate cancer CRPC directly contributes to patient mortality It is imperative to develop new and effective adjunct therapy to enhance the response of CRPC to hormonal therapy Recently we developed ProFineTM a proprietary formula consisting of bioactive flavonoids enriched in pomegranate fruit and ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Enhancing Care of the Aged and Dying in Prisons

    SBC: KLEIN BUENDEL, INC            Topic: NIA

    DESCRIPTION provided by applicant The United States has the highest rate of incarceration in the world The demographics of the prison population are shifting In fact the number of sentenced state and federal prisoners age or older grew at times the rate of the overall prison population from The health status of aging inmates does not mirror the free world population In fac ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Nutritional Therapy in Elderly with Heart Failure

    SBC: Essential Blends, LLC            Topic: NIA

    DESCRIPTION provided by applicant The long term goal of this project is to develop and test a nutritional product that will improve physical function in individuals with heart failure H in the geriatric population Our approach to nutritional therapy NT focuses on increasing skeletal muscle strength improving vascular reactivity and optimizing regulation of energy substrate metabolism All ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Oral rice-derived lactoferrin reduced the severity of Crohn's disease through anti-inflammatory regulation of T cells

    SBC: VENTRIA BIOSCIENCE            Topic: NIAID

    DESCRIPTION provided by applicant The scope of this proposed study is to demonstrate the efficacy of recombinant human lactoferrin rhLF to act as an immune modulator through T cell regulation in distinct murine models of inflammatory bowel disease IBD which best recapitulate Crohnandapos s like ileitis and colitis Crohnandapos s disease CD affects as many as people in the United ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Muscle preservation during weight loss in older, overweight individuals

    SBC: Essential Blends, LLC            Topic: N

    DESCRIPTION provided by applicant The overall goal of this project is to test a meal replacement beverage that will ultimately preserve muscle loss during calorie restriction weight loss CRWL in obese older individuals We previously developed a meal replacement rich with a proprietary blend of essential amino acids TMR that was more than three times as effective as whey protein in stimulat ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Design, Development, and Evaluation of an Interactive Tactile Graphics Printer for the Blind and VisuallyImpaired

    SBC: E.A.S.Y. LLC            Topic: 400

    DESCRIPTION provided by applicant The ultimate goal of this project is to market an electromechanical and software system for Blind and Low Vision B LV individuals that will enable interactive creation communication and printing of Braille annotated tactile graphics In school at home and in the workplace virtually everyone needs to be able to produce a wide variety of freehand sketches ...

    STTR Phase II 2015 Department of Health and Human Services
  8. Enhanced multiphoton microscopy through spatial light modulation

    SBC: Boulder Nonlinear Systems, Inc.            Topic: 102

    DESCRIPTION provided by applicant Nonlinear optical microscopy techniques and particularly multiphoton fluorescence microscopy have become popular tools for visualizing the three dimensional cellular architecture residing hundreds of microns and up to one millimeter deep in living organisms This is particularly valuable in neurobiology where multiphoton techniques have become widely used fo ...

    STTR Phase II 2015 Department of Health and Human Services
  9. iDDS probes detecting IDH mutants in brain cancer

    SBC: GENETAG TECHNOLOGY, INC.            Topic: 102

    DESCRIPTION provided by applicant Glioblastoma accounts for of all brain tumors and is the most common and most malignant form of glioma Primary glioblastomas show rapid disease progression without precursor lesions whereas secondary glioblastomas generally originate as low grade astrocytomas that form grade IV gliomas over a period of years Without prior knowledge of a patientanda ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Intervening to Prevent Youth Access to Marijuana

    SBC: KLEIN BUENDEL, INC            Topic: R43

    DESCRIPTION provided by applicant The legalization of marijuana in Colorado and Washington in is the most dramatic change in substance abuse policy in the United States since the end of Prohibition These states are implementing regulatory and enforcement systems for the retail sales of recreational marijuana to adults years or older akin to state controls on the sale of alcohol In ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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