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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Device for Otitis Media Diagnosis

    SBC: OTONEXus MEDICAL TECHNOLOGIES, Inc.            Topic: Y

    OtoNexus is developing the world s first medical device to provide definitiveobjective diagnostic data for the rapid and accurate diagnose middle ear infectionscalled Otitis Mediain children and adultsThis FAST TRACK proposal addresses the clinical difficulty of determining the nature of fluid behind the tympanic membraneear drumin acute infection of the middle earAcute Otitis MediaAOMClinical stu ...

    SBIR Phase II 2017 Department of Health and Human Services
  2. A Phase Clinical Trial Evaluating the Novel Small Molecule Immuno Oncology Antagonist SX Alone and With Pembrolizumab in Metastatic Melanoma

    SBC: Syntrix Biosystems, Inc.            Topic: 102

    The chemokine receptors CXCR and CXCR CXCR are validated as having essential roles in the growth survival motility invasion and angiogenesis of human melanoma which secretes abundant amounts of the corresponding chemokine ligands including CXCL Additionally abnormal cancer induced immunosuppressive myeloid derived suppressor cells MDSCs in the circulation and tumor correlate with ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Micropatterned surfaces for minimizing pediatric gastrostomy tube complications

    SBC: Sharklet Technologies Inc.            Topic: NICHD

    Summary In a variety of diseases and conditions when oral feeding is impossibleenteral feeding through percutaneous gastrostomyPGis necessary to provide long term nutrition for adult and pediatric patientsIt is estimated that overthousand feeding tubes are placed in pediatric patients in the US annuallyHoweverthese patients frequently experience complications associated with PG tube placementLate ...

    SBIR Phase II 2017 Department of Health and Human Services
  4. Development of Site-specific O-GlcNAc Antibodies for Epigenetic Research

    SBC: GlycoScientific, L.L.C.            Topic: 300

    Project SummaryO glycosylation of nuclear and cytoplasmic proteins by a singleN acetyl D glucosamine moietyOGlcNAcis a common post translational modification that is highly dynamic and fluctuates in response to cellular stimuliThis type of glycosylation has been found on approximately a thousand human proteins to dateand is thought to be nearly as wide spread and abundant as protein phosphorylatio ...

    SBIR Phase II 2017 Department of Health and Human Services
  5. Tough Talks: A Disclosure Intervention for HIV+ YMSM

    SBC: VIRTUALLY BETTER INC            Topic: 105

    PROJECT SUMMARY Men who have sex with menMSMaccount for nearly two thirds all of new HIV infections in the United StatesUSand young MSMYMSMare the only risk group experiencing a significant increase in HIV incidenceAmong youthpercent report not disclosing to their first time sex partnersDisclosing of one s HIV status is important for accessing support which can lead to improved medication adherenc ...

    SBIR Phase II 2017 Department of Health and Human Services
  6. Small molecule therapy for metastatic prostate cancer

    SBC: MetCure Therapeutics LLC            Topic: 102

    Enzalutamide resistance is a major obstacle in the treatment of metastatic castration resistant prostate cancer mCRPC Recently we developed a small molecule lead compound GH and demonstrated its potent activity against bone metastatic prostate cancer cells In this Phase I STTR application we hypothesize that GH is a novel lead compound with nanomolar potency against enzalutamide resist ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a protein drug for pancreatic cancer treatment

    SBC: ProDa BioTech L.L.C.            Topic: NCI

    Abstract Pancreatic cancers are devastating diseases with five year survival rate less than Currently there is no effective treatment for advanced disease One major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal response Evidence suggests that cancer associated pancreatic stellate cells CAPaSC produce the stromal collagen The ECM laid down by CAPaSC is c ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. CruziScreen a recombinant antigen based screening test for Chagas disease

    SBC: PAI Life Sciences, Inc.            Topic: NIAID

    Project Summary Chagas disease is a severe inflammatory syndrome caused by infection with a protozoan parasite Trypanosoma cruzi Although transmission occurs mostly through an intermediate insect host the infection is silent and chronic carriers pose a significant risk through the transfer of infected products made from donated blood of these individuals to blood recipients Up to new c ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. E training of Inmate Peer Caregivers for Enhancing Geriatric and End of life Care in Prisons

    SBC: KLEIN BUENDEL, INC            Topic: NIA

    The US has the highest incarceration rate in the world imprisoning people per The older adult segment of the prison population has more than tripled since and their health issues are common to free people who are years their senior Inmates over the age of have a death rate that is times that of prisoners aged US prison systems are facing sharply increased dema ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Screening for the autoimmune component of multiple sclerosis

    SBC: Op-T-Mune, Inc            Topic: NIAID

    Multiple Sclerosis is an inflammatory neurodegenerative disease with autoimmune components that exacerbate and potentially initiate the disease Diagnosis is invasive time consuming relatively expensive and extremely difficult In fact no clear diagnostic test yet exist A major concern is that MS symptoms are identical to the symptoms of numerous other neurologic diseases OND as well as some ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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