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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Selenium-derivatized New Reagents for Nucleic Acid X-ray Crystallography

    SBC: SENA RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

    STTR Phase II 2015 Department of Health and Human Services
  2. Anti-CXCL13 mAb to mitigate prostate cancer health disparities

    SBC: JYANT Technologies, Inc.            Topic: NIMHD

    DESCRIPTION provided by applicant The most common metastatic site for hormone refractory prostate cancer HRPC PCa is bone While docetaxel can prolong the overall survival in patients with metastatic HRPC current treatments do not provide a cure Further complicating the matter HRPC is a disease that affects a variety of patients differently which can be problematic for physicians to prov ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Diagnosis of Bacterial Infections with Maltodexrins

    SBC: Microbial Medical, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant We present a new family of contrast agents based on targeting the maltodextrin transporter termed maltodextrin based imaging probes MDPs which are designed to image infections associated with implanted medical devices by fluorescent imaging The chemical structure of an MDP is composed of maltodextrins conjugated to a fluorescent dye MDPs have the potentia ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Humanization of VLR antibodies for therapeutic applications

    SBC: Novab, Inc.            Topic: 102

    DESCRIPTION provided by applicant Currently there is no FDA approved therapeutic antibody capable of depleting long lived plasma cells A plasma cell specific monoclonal antibody could be used to treat plasma cell malignancies multiple myelomas which are fatal and for which there is no effective treatment and antibody mediated autoimmune and severe allergic disease e g systemic lupus e ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Novel probes detecting ROS1,ALK and RET fusions and mutations in NSCLC

    SBC: GENETAG TECHNOLOGY, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is one of the leading causes of death worldwide and lung carcinoma is the leading cause of cancer related death Lung cancer is classified histologically as either small cell lung carcinoma SCLC of lung cancers or non small cell lung carcinoma NSCLC of lung cancers Genetic alterations driving NSCLC are known in only of cases an ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Directed Lineage Immunizations for Eliciting Broadly Neutralizing Antibody

    SBC: GEOVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The proposed project Directed Lineage Immunizations for Eliciting Broadly Neutralizing Antibody tests the directed lineage D L approach to HIV vaccination using clade C immunogens With a D L vaccine a series of progressively evolved Env immunogens are used to drive development of a broadly neutralizing antibody bnAb response which is important because ...

    SBIR Phase I 2015 Department of Health and Human Services
  7. Patient-Tailored Selective Laser Melt-Fabricated Plates for Repair of Foot and Ankle Pathology

    SBC: MEDSHAPE, INC.            Topic: NIAMS

    DESCRIPTION provided by applicant The objective of this project is to develop novel patient specific geometrically complex Titanium Ti alloy plates made by additive manufacturing AM also called D printing for foot and ankle applications These plates will offer superior fixation and mechanical performance while minimizing the plate bulk volume Foot and ankle surgeries are common wh ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Endophyte Assisted Phytoremediation of Arsenic

    SBC: Edenspace Systems Corporation            Topic: NIEHS

    DESCRIPTION provided by applicant Agricultural application of arsenate based pesticides from the s through s left significant acreage of arsenic residues particularly on land used for apple potato and blueberry farming Arsenate was applied at rates up to kg ha in most fruit orchards until insecticides such as DDT were introduced the late s resulting in contamination over lar ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Shape-Memory Polymer Device for Distraction Enterogenesis to Treat Short Bowel Syndrome

    SBC: MEDSHAPE, INC.            Topic: 300

    DESCRIPTION provided by applicant Short bowel syndrome SBS results in significant morbidity and mortality in children and adults It is a chronic condition that occurs in up to i live births affects at least adults and costs more than $ billion annually in the United States SBS is caused by loss of intestinal length and thus digestive and absorptive capacity as a resu ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. A next-generation spatial light modulator for mapping of neural networks

    SBC: Boulder Nonlinear Systems, Inc.            Topic: NIBIB

    DESCRIPTION provided by applicant Improving our understanding of the fundamental circuitry and dynamics of the brain has far reaching implications for a wide range of fields including mental health computing and the philosophy of the mind To this end one of the critical questions currently facing neuroscientists lies in how brain states and behaviors arise from the activity of ensembles of ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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