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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Microfluidic S nitrosothiol Sensor

    SBC: CLINICAL SENSORS, INC.            Topic: 400

    PROJECT SUMMARY This Small Business Innovation Research SBIR Phase I project aims to develop an accurate rapid and commercially available microfluidic sensor that measures low molecular weight S nitrosothiols in biological samples S nitrosothiols RSNOs the primary transporters of nitric oxide NO in physiology play a critical role for NOandapos s bioactivity Homeostatic control of low ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. High throughput screening of arrayed single cells for automated analysis of phenotypic heterogeneity

    SBC: Celldom, Inc.            Topic: 300

    ABSTRACT The overall objective of this SBIR Phase I proposal is to develop a high throughput screening platform that can analyze the phenotypic heterogeneity of single cells exposed to small molecule growth inhibitors To achieve this objective we will conduct the following specific aims demonstrate a commercially viable approach for rapidly organizing andgt single cells into an arra ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Fluorescent reporters for real time single cell Pol III transcription measurement

    SBC: Lucerna Inc.            Topic: 400

    SUMMARY RNA polymerase III Pol III is increasingly recognized as an important drug target and a rapidly developing area of academic research Pol III is responsible for generating RNAs that are critical for cell growth such as tRNAs certain rRNAs and various noncoding RNAs involved in processes such as mRNA splicing These RNAs are required for cell growth proliferation and differentiation ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Centralized assay datasets for modelling support of small drug discovery organizations

    SBC: COLLABORATIONS PHARMACEUTICALS, INC.            Topic: 400

    Summary The objective of Assay Central is to compile a comprehensive collection of datasets for structure activity data for a broad variety of disease targets and absorption distribution metabolism excretion and toxicology ADMET properties in a form that is immediately ready for model building and other forms of analysis using cheminformatics methods This is aided by the existence of many ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A Topical Nrf Activator for Oral Mucositis

    SBC: Pathways Bioscience, LLC            Topic: NIDCR

    We propose to develop a topical formulation for preventing or treating oral mucositis Oral mucositis is a common and harmful side effect of radiation therapy and chemotherapy in cancer patients that affects nearly patients in the US annually and can be dose limiting impairing the clinical ability to continue the otherwise needed therapy and that also greatly impacts the patientandapos s ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Crossover Study of an Oral Treatment for Sickle Cell Disease

    SBC: INVENUX, LLC            Topic: NHLBI

    ABSTRACT Sickle cell disease SCD affects approximately people in the United States and millions worldwide Symptoms appear shortly after birth and in less developed countries the majority of children with SCD die before the age of five In the U S SCD patients suffer chronic pain and fatigue severe acute painful crises requiring hospitalization and opiates strokes and multi organ ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Plastic Parenteral Container with Superior Barrier Properties for Biologics

    SBC: TRIBOFILM RESEARCH INC            Topic: NHLBI

    PROJECT ABSTRACT Plastic offers several key advantages over Type borosilicate glass as a material for parenteral pharmaceutical containers e g vials and prefilled syringes Plastic is less prone to breakage and can be molded into more complex shapes with tighter dimensional tolerances than glass Additionally plastic is not susceptible to glass delaminati ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A phosphopeptide multiplex PRM mass spectroscopic biomarker assay for PAH

    SBC: Pulmokine, Inc.            Topic: NHLBI

    The purpose of this phase SBIR grant is to develop a quantitative phosphopeptide biomarker assay for pulmonary arterial hypertension PAH The commercial product will consist of a kit of stable isotopically labeled internal standards of a selected set of phosphopeptides either up or down regulated in PAH The set of stable isotopically labeled peptides will be used in a parallel reaction monito ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. FMRI Dynamic Phantom for Improved Detection of Resting State Brain Networks

    SBC: ALA SCIENTIFIC INSTRUMENTS, INC.            Topic: NIDA

    Abstract Functional magnetic resonance imaging fMRI has rapidly become the dominant tool in human neuroscience research and is poised to become a transformative technology in the areas of psychiatric and neurological diagnostics In recent years large scale $ M $ B USD and long term year international investments e g NIDA Adolescent Brain Cognitive Development Study NIH Human ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Small Molecule Macrophage Inhibitors for the Treatment of Retinal Diseases

    SBC: Eyedesis Biosciences, LLC            Topic: N

    PROJECT SUMMARY ABSTRACT Persistent disease activity PDA in spite of anti vascular endothelial growth factor VEGF therapy remains a significant clinical unmet need for patients with neovascular age related macular degeneration NVAMD The purpose of this STTR Phase I grant application is to develop novel therapies that will be effective for the treatment of PDA associated with NVAMD The cu ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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