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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. BrainAware: Interactive digital psychoeducation for adolescents and young adults with substance use disorders

    SBC: Andamio Games, LLC            Topic: 500

    Project Summary Abstract Treatment professionals struggle to get adolescents and young adults to engage and persist with treatment for substance abuse disordersIt is particularly difficult to maintain interest or enthusiasm with two core elements of evidence based substance abuse treatmentpsychoeducation and peer supportWe propose to counter young peopleandapos s resistance to treatment by creatin ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Development of mitochondrial disease mouse models

    SBC: B-MoGen Biotechnologies Inc            Topic: OD

    Project Abstract Mitochondria are double membrane bound organelles that are found in all eukaryotic cells and carry a specialized circularkb genomeThere is a group of devastating human genetic diseases caused by inherited or spontaneous mutation of genes encoded within the mitochondrial genomeThese diseases can cause a wide array of medical problems from subtle muscular weakness to extreme neuromu ...

    STTR Phase I 2018 Department of Health and Human Services
  3. Clinical evaluation of combination oncolytic viro-immunotherapy for solid tumors

    SBC: Vyriad, Inc.            Topic: 102

    PROJECT SUMMARY ABSTRACTNon small cell lung cancerNSCLCand hepatocellular carcinomaHCCare leading cause of cancer death globallyImmune checkpoint inhibitorsCPIswhich block tumor immune evasion signals and activate T cell mediated antitumor immunityhave demonstrated clinical efficacy and are approved for several cancers including NSCLC and HCCDespite this broad spectrum of activityless thanof patie ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Modeling Disease in Swine by Transplantation of Gene Targeted Germ Cells

    SBC: Recombinetics, Inc.            Topic: 400

    PROJECT SUMMARY Swine are important in biomedical research for the study of human diseases that are poorly recapitulated by rodent speciesfor the development and testing of preclinical therapeutics in humanized disease models and as potential sources of xenogeneic or allogeneic organs and tissuesHoweverthe creation and propagation of biomedical swine is plagued by inefficiencies related to animal ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Validation of Novel Therapeutic Approach for Leptomeningeal Metastases

    SBC: Minnetronix Medical, Inc.            Topic: 102

    ABSTRACT Leptomeningeal MetastasesLMis a condition in which tumor cells from a primary tumor metastasizeinvade the subarachnoid spaceSASand spread throughout the cerebrospinal fluidCSFresulting in seeding along the meningesbrain and spinal cordLM represents a devastating event of cancer progressionThere arecases annually and currently no curewith average survival ofmonths with current therapiesRed ...

    STTR Phase II 2018 Department of Health and Human Services
  6. Exercise Evaluation and Recovery Therapy(EXERT)

    SBC: Korosensor.Com, Inc.            Topic: NIA

    Abstract Eden MedicalIncis pleased to submit this PhaseSBIR proposal to develop the Exercise Evaluation and Recovery TherapyEXERTsystema mobile healthmHealthsolution for assessing exercise impairment of adult peripheral vascular diseasePVDpatients and increasing their exercise capacityOvertaxing during exercise could be highly dependent on muscle oxidative capacity and muscle deoxygenationWhile th ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Technology assisted treatment for trichotillomania

    SBC: Habitaware, Inc.            Topic: 102

    Abstract SignificanceTrichotillomaniaTTMcharacterized by repeated pulling of one s hair to the point of hair loss or thinningproduces impairment in physicalsocialpsychological and occupational functioningEmpirically supported treatment options for those with TTM are seriously limitedAmong treatments shown to be effective is behavior therapyUnfortunatelybehavior therapy is limited in that developin ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Rapid Non-Viral Platform for Generation of Genetically Modified T Cells for Therapy

    SBC: B-MoGen Biotechnologies Inc            Topic: 100

    Abstract Cancer immunotherapyparticularly genetically engineered adoptive T cell transferhas shown great potential for the treatment of cancer patientsThe use of T cells engineered to express a specific T cell receptorTCRsor chimeric antigen receptorCARsto treat cancer has generated durable cures for many cancer patients and has resulted in the first FDA approved CAR T therapy to treat childhood a ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Mixed Reality System for STEM Education and the promotion of health-related careers

    SBC: Innovative Design Labs Inc.            Topic: 400

    Project Summary Abstract Proposed is a system to combine and leverage the advantages of existing medical props with interactive media to provide engaging and cooperative group STEM learning experiencesSignificanceThe PowerPoint lecture style has become the standard method for teaching groups of studentsUnfortunatelythis style does not emphasize student instructor or student student instructionand ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Long-Wavelength FRET Pairs for Fluorescence Lifetime HTS Assays in Living Cells

    SBC: Fluorescence Innovations Inc            Topic: 100

    Project Summary The purpose of this project is to enhance the capabilities of a novel drug discovery platform that has already been brought to commercializationSpecificallythe focus is live cell fluorescence resonance energy transferFRETassays monitored by changes in the donor s fluorescence lifetime using our direct waveform recordingDWRmethodologywhich affords exceptional speed and precisionWork ...

    SBIR Phase I 2018 Department of Health and Human Services

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