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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. SpliceCore: A Cloud-Based Software Platform to Translate Alternative Splicing Events into Therapeutic Targets Using RNA-seq Data

    SBC: ENVISAGENICS INC            Topic: 400

    Abstract Overmillion people in the US suffer from genetic diseases or cancers caused by mutations of whichdisrupt the regulation of splicingAlternative splicingASerrors have been reported in literature to drivegenetic diseases out ofdescribed to dateIn additiondue to the recent success of FDA approved splicing modulators like Nusinersenalong with fascinating preclinical results underlining the imp ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A Phase 1 Clinical Trial Evaluating the Novel Small Molecule Immuno-Oncology Antagonist SX-682 Alone and With Pembrolizumab in Metastatic Melanoma

    SBC: Syntrix Biosystems, Inc.            Topic: 102

    The chemokine receptors CXCR1 and CXCR2 (CXCR1/2) are validated as having essential roles in the growth, survival, motility, invasion and angiogenesis of human melanoma, which secretes abundant amounts of the corresponding chemokine ligands, including CXCL8. Additionally, abnormal cancer-induced immunosuppressive myeloid-derived suppressor cells (MDSCs) in the circulation and tumor correlate with ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. The Variant Explorer: a cloud-based data integration and visualization system for improving clinical interpretation of sequenced genetic variants.

    SBC: Solve, Inc.            Topic: 400

    Project Summary SolveBio is the operating system for molecular informationSolveBio provides data infrastructure with genomics specific mapping technology and application programming interfacesAPIsand graphical user interfacesGUIsfor scientistsbioinformaticiansand software engineersThe goal of this Phase II SBIR proposal is to develop the Variant ExplorerVEa cloud based graphical analysis software ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Validation of Cross-Species Biomarkers of DNA Damage

    SBC: Litron Laboratories Ltd            Topic: 113

    Project Summary This project will validate two high throughput human blood based DNA damage assays and develop them into commercial kitsThe assays monitor types of damage associated with important human diseasesWhereas the PIG A assay reports on gene mutationthe micronucleated reticulocyteMN RETassay is responsive to chromosomal breaks and or lossesThe biomarkers are applicable to both humans and ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing

    SBC: TWINSTRAND BIOSCIENCES INC            Topic: 102

    Nearly a quarter of a million new cases of ovarian cancer are identified every year worldwide and the majority of these woman will die from their disease. When detected early, surgical cure rates exceed 90%, but currently most cases are detected at an advanced stage when the cancer has already disseminated. As such, our most pressing problem in ovarian cancer is a lack of tools to identify early s ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. CAMS Relational Agent System (CAMS-RAS) for Suicide Prevention

    SBC: EVIDENCE-BASED PRACTICE INSTITUTE, INC.            Topic: 104

    PROJECT ABSTRACTOver 44,000 people die annually by suicide in the United States (US) making suicide the 10th leading cause of death overall and the second leading cause of death among those 10-44. In addition, 9.8 million adults contemplate suicide annually, and one million will make a suicide attempt. From 2006 to 2013, the rate of ED visits for suicidal ideation among adults increased by 12% on ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Methodology for Identification of Senolytics that Reduce Age-related Disease and Dysfunction

    SBC: Recursion Pharmaceuticals, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): Chronic diseases of aging account for a significant proportion of healthcare spending and result in a painful and limiting existence for many tens of millions of Americans and hundreds of millions of people around the world. Recursion Pharmaceuticals has developed a drug discovery platform that re-purposes known drugs for the treatment of such diseases. The pla ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Anti-ceramide scFv as Mitigator of the Radiation GI Syndrome

    SBC: Ceramedix Holding, LLC            Topic: NIAID

    Project Summary/Abstract Inhibition of ceramide protects mice from death from the Radiation GI Syndrome (RGS). Administration of anti- ceramide single-chain Fv (scFv) 24 h post radiation exposure increases survival in intestinal stem cells and dramatically improves overall survival in mice. These data indicate that anti-ceramide scFv represents the first effective mitigator of lethal RGS. To advan ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Expressive Speech Synthesis for Speech-Generating Devices

    SBC: SYNFONICA LLC            Topic: NIDCD

    Project SummaryThe expression of emotions through speech is an essential element of human communicationyet individuals with speech impairments who rely on speech generating devicesSGDsto talk are largely deprived of this communicative channelNo one should be forced to sound blaswhen in fact they re elated or to sound apathetic when they intend to scoldWhile certain expressive speech modes are offe ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. An Automated Early Motor Development Risk Screener from Observational Video Recordings of Infants and Toddlers

    SBC: BSOLUTIONS, INC.            Topic: NICHD

    Motor development plays a pivotal role in an infant’s overall development and has a cascading effect on social, cognitive, memory, and language ability. These functions can be compromised when motor development is disrupted; motor disruption is associated with generalized developmental delays. Early screening and identification of delays can allow early interventions with the goal of not just im ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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