Award Data

Summary: Ovarian cancer is the leading cause of death from gynecologic malignancy. Most women are diagnosed with metastatic ovarian cancer, and the 5-year survival rate for this late stage disease is less than 28%. The mainstay of treatment for ovarian cancer entails debulking cytoreductive surgery in combination with adjuvant chemotherapies. Unfortunately, severe side effects of these chemotherap ...

Summary: According to the most recent CDC report, the incidence of sepsis in the United States is over 1.7 million each year, resulting in about 270,000 deaths and over $20 billion in healthcare costs. Sepsis results from infection of any microorganisms with bacteria being the most common. Pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharides (LPS) activate innate immune cell ...

PROJECT SUMMARY - PEDIATRIC HEART VALVE WITH EXPANSION CAPABILITYCongenital heart valve defects are detected in nearly 40,000 infants born in the United States each year (Alsoufi 2014). The heart valve defect can range in severity, with about 25% of cases (about 13,000) requiring immediate open- heart surgery to replace the valve or other heart defects. Currently, there is no surgical heart valve ...

PROJECT SUMMARYAminoglycosides are one of the cheapest and well-known antibiotics in clinical use for over 70 years, but one of the major limitations in their use is their ototoxicity. We are developing fast and low-cost methods to develop aminoglycosides with anti-ribosomal activities and reduced toxicity. In this project, we will identify novel aminoglycoside antibacterials, that show reduced ot ...

Project Summary A novel coronavirus (SARS-CoV-2) has become one of the greatest challenges of the modern world and has caused a pandemic with millions of infected people and hundreds of thousands of deaths around the globe. Transmissions occur through respiratory droplets, as well as through contaminated hands and environmental surfaces. Therefore, cleaning and disinfection of potentially contamin ...

Project Summary The long-term goal of this project proposal is to develop and commercialize a therapy to assist pre-term, and term infants with hypoxic ischemic brain injury (HIE), with feeding difficulty. Independent feeding is critical for infants to be discharged home with their families and avoid a gastrostomy tube (G-tube) placement. The current standard of care for infants with feeding diffi ...

PROJECT SUMMARY The lack of a means to quantify soft tissue manipulation (STM) motion and dose as delivered in the clinic is a critical problem in the reproducibility and therapeutic potential of this non-invasive and non-pharmacological modality. STM is a form of manual therapy used to evaluate and treat musculoskeletal pain, inflammation, and dysfunction. Different soft tissue forces have differ ...

PROJECT SUMMARY FOR PREDICATE STTR PHASE I GRANT Perioperative and prescribed opioids often result in costly and unpredictable adverse effects, including life threatening respiratory depression and long-term opioid use/misuse in vulnerable patients. The US FDA warns against the use of codeine and tramadol in children due to postoperative anoxic brain injuries and deaths, and in nursing mothers due ...

Liver fibrosis/cirrhosis affects more than 100 million people worldwide and represents one of the most common causes of death in adults. Currently no effective pharmacotherapy is available for liver fibrosis. The only proven therapy is liver transplantation. Recent studies implicate that some isoforms of histone deacetylase (HDAC) play a role in development of liver fibrosis but all current HDAC i ...

---Project Summary/Abstract ---- Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer. Poor survival rates are largely due to the late stage at which PDAC is diagnosed and a lack of effective therapies. The long-term goal of this research program is to discover new immunotherapeutic approaches for the treatment of PDAC. Preliminary studies by our group and others have sh ...