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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Novel therapeutic for hematopoietic stem cell regeneration in bone marrow post my

    SBC: Minerva Biotechnologies Corporation            Topic: NIAID

    DESCRIPTION (provided by applicant): The purpose of this study is to establish in vivo proof of principle for a human therapeutic for hematopoietic stem cell regeneration in the bone marrow after myeloablation from radiation. Blood stem cells are the mostsusceptible to the effects of radiation and the most lethal. We have already demonstrated proof of principle for our therapeutic in vitro. If suc ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A Novel Immunotolerizing Therapy for Autoimmune Vitiligo

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): Radikal Therapeutics (RTX) is pioneering a novel therapy to restore immune tolerance and arrest progressive depigmentation in vitiligo. At Loyola University (LUC), a variant to inducible Heat Shock Protein 70 was developed with remarkable potential for the prevention and treatment of autoimmune vitiligo. Carrying only a single amino acid modification to the pro ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Novel mechanism-based targeted approach to rheumatoid arthritis

    SBC: SIGNABLOK, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that causes chronic inflammation of the joints. RA affects about 1.5 million Americans and costs society more than 40 billion each year. Despite advances in therapy, RA has no cure. Current treatments of RA include non-steroidal anti- inflammatory drugs, corticosteroids, and disease modifyi ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Development of SFS Fractionators

    SBC: APHIOS CORPORATION            Topic: NCCIH

    DESCRIPTION (provided by applicant): The screening of a complex mixture of analytes is not always successful in sensitive screens for specific activities. Often, specific activities are masked by interfering compounds or false positives are given by ubiquitous compounds that interact with all screens. This problem can be resolved by purification of the analytes. Such an approach is not only cost-p ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Real-time assessment of surgical margins with enhanced contract optical imaging

    SBC: PHYSICAL SCIENCES INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with Massachusetts General Hospital proposes to investigate the use of a high sensitivity/specificity cancer targeting agent and of a novel fluorescence-guided microscopy(FGM) scheme for intraoperative assessment of surgical margins in breast cancer patients. The contrast agent will be used to label cancer cells a ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Expression System and Process Development for MIS Scale Up

    SBC: NEMUCORE MEDICAL INNOVATIONS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Ovarian cancer is a highly lethal gynecologic cancer with an estimated 21,860 new cases and approximately 13,850 deaths in the USA per year. A large majority of the patients, cancer reoccurs after initial treatment and manifest resistance to conventional and novel chemotherapeutic agents representing a formidable clinical challenge, which could be mitigated b ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Robust and Efficient Method for Pharmaceutical Freeze Drying in Pre-Filled Syringes

    SBC: PHYSICAL SCIENCES INC.            Topic: NCI

    DESCRIPTION (provided by applicant): The goal of the proposed SBIR program is to develop lyophilizer manufacturing hardware and processing procedures that enable the efficient freeze drying of pharmaceutical product formulations in prefilled syringes. Theuse of prefilled syringes 1) reduces dosing and medication errors, 2) reduces the risk of microbial contamination, 3) improves dosing accuracy, 4 ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Integrated System for FFPE Sample Preparation

    SBC: COVARIS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Many samples taken from individuals and animals are stored by treating them with chemical, formalin, and then encasing them in paraffin or wax; these are called formalin fixed paraffin encased (FFPE) samples. Usually this storage is very good for preserving them for observation under microscopes, but it presents some problems in terms of analysis of their DNA. ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Large Scale Synthesis and Biodistribution of Expansile Nanoparticles

    SBC: IONIC PHARMACEUTICALS, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Despite aggressive multimodality therapy combining surgery, radiation, and/or chemotherapy, mesothelioma is a nearly universally fatal cancer with the majority of patients succumbing to symptoms of local recurrence. Todate, there is no effective cure for this disease and there is no way to prevent local recurrence. Consequently, new drug delivery approaches, bi ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. An Intraoperative Guidance Platform for Radio Frequency Ablation

    SBC: NE SCIENTIFIC LLC            Topic: NCI

    DESCRIPTION (provided by applicant): The objective of this proposed research program is to develop a platform for planning and guidance during Radio Frequency Ablation (RFA). RFA is a thermally mediated ablation technique, where an applicator carrying oneelectrode is inserted into tumors percutaneously (or via laparoscopy, or open surgical approaches). Radio Frequency (RF) energy is applied, denat ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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